IFT43_CAEEL
ID IFT43_CAEEL Reviewed; 200 AA.
AC Q9BIA4;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Intraflagellar transport protein 43 homolog {ECO:0000305};
GN Name=ift-43 {ECO:0000303|PubMed:28479320};
GN ORFNames=C25H3.12 {ECO:0000312|WormBase:C25H3.12};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, IDENTIFICATION IN IFT COMPLEX A, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DISRUPTION PHENOTYPE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=28479320; DOI=10.1016/j.cub.2017.04.015;
RA Yi P., Li W.J., Dong M.Q., Ou G.;
RT "Dynein-driven retrograde intraflagellar transport is triphasic in C.
RT elegans sensory cilia.";
RL Curr. Biol. 27:1448-1461(2017).
CC -!- FUNCTION: As a component of IFT complex A (IFT-A), a complex required
CC for retrograde ciliary transport and entry into cilia of G protein-
CC coupled receptors (GPCRs), it is involved in ciliogenesis (Probable).
CC In particular, may act redundantly with the intraflagellar transport
CC protein ift-139 to regulate the transport of specific ciliary cargo
CC proteins such as che-3 which are related to motility.
CC {ECO:0000269|PubMed:28479320, ECO:0000305|PubMed:28479320}.
CC -!- SUBUNIT: Component of the IFT complex A (IFT-A) composed of at least
CC che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
CC {ECO:0000269|PubMed:28479320}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:28479320}.
CC -!- TISSUE SPECIFICITY: Expressed in ciliated sensory neurons.
CC {ECO:0000269|PubMed:28479320}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, with no defects in cilium
CC morphology. Double knockout with intraflagellar transport protein ift-
CC 139 results in defective cilium morphology and function.
CC {ECO:0000269|PubMed:28479320}.
CC -!- SIMILARITY: Belongs to the IFT43 family. {ECO:0000305}.
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DR EMBL; BX284602; CCD65040.1; -; Genomic_DNA.
DR RefSeq; NP_495107.1; NM_062706.1.
DR AlphaFoldDB; Q9BIA4; -.
DR ComplexPortal; CPX-1289; Intraflagellar transport complex A.
DR EPD; Q9BIA4; -.
DR PaxDb; Q9BIA4; -.
DR PeptideAtlas; Q9BIA4; -.
DR EnsemblMetazoa; C25H3.12.1; C25H3.12.1; WBGene00016121.
DR GeneID; 173959; -.
DR KEGG; cel:CELE_C25H3.12; -.
DR UCSC; C25H3.12; c. elegans.
DR CTD; 173959; -.
DR WormBase; C25H3.12; CE27092; WBGene00016121; ift-43.
DR eggNOG; ENOG502THQ5; Eukaryota.
DR HOGENOM; CLU_1462635_0_0_1; -.
DR InParanoid; Q9BIA4; -.
DR OMA; NMARISA; -.
DR OrthoDB; 1473872at2759; -.
DR PRO; PR:Q9BIA4; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00016121; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005929; C:cilium; IC:ComplexPortal.
DR GO; GO:0030991; C:intraciliary transport particle A; IC:ComplexPortal.
DR GO; GO:0035721; P:intraciliary retrograde transport; IC:ComplexPortal.
PE 1: Evidence at protein level;
KW Cell projection; Reference proteome.
FT CHAIN 1..200
FT /note="Intraflagellar transport protein 43 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000442208"
FT REGION 56..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 200 AA; 22306 MW; 48B1233B7E54B4AE CRC64;
MIILENEANE PGFRIQQRAE SETGKKGRFG GILKENPIKG FSSETLTRPL TGLFRKTGKS
QRKTDDDDSQ ETIAAPPTNF PNMARISATI ESVQINDEYA GYRDRNPETG SKLTLNEGAG
VFGNAMHPLT RYFKVGDVDV SILGRSFPTE KTVDEEGPWT AQSLFNSLES RIKKERIDAK
DQPSDSRSRN ARETLISSKY
