ID   IFT43_CHLRE             Reviewed;         272 AA.
AC   A8HYP5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Intraflagellar transport protein 43;
GN   Name=IFT43; Synonyms=MOT41; ORFNames=CHLREDRAFT_142470;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cole D.G., Lucker B.F., Behal R.H., Blasick C.M.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503, and cw92;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12795688; DOI=10.1034/j.1600-0854.2003.t01-1-00103.x;
RA   Cole D.G.;
RT   "The intraflagellar transport machinery of Chlamydomonas reinhardtii.";
RL   Traffic 4:435-442(2003).
CC   -!- FUNCTION: As a component of IFT complex A (IFT-A), a complex required
CC       for retrograde ciliary transport and entry into cilia of G protein-
CC       coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in
CC       retrograde ciliary transport along microtubules from the ciliary tip to
CC       the base. {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBUNIT: Component of the IFT complex A (IFT-A) complex.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
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DR   EMBL; EF586682; ABU93234.1; -; mRNA.
DR   EMBL; DS496110; EDP08630.1; -; Genomic_DNA.
DR   RefSeq; XP_001696653.1; XM_001696601.1.
DR   AlphaFoldDB; A8HYP5; -.
DR   STRING; 3055.EDP08630; -.
DR   PaxDb; A8HYP5; -.
DR   PRIDE; A8HYP5; -.
DR   EnsemblPlants; PNW81550; PNW81550; CHLRE_06g251200v5.
DR   GeneID; 5722198; -.
DR   Gramene; PNW81550; PNW81550; CHLRE_06g251200v5.
DR   KEGG; cre:CHLRE_06g251200v5; -.
DR   HOGENOM; CLU_1024345_0_0_1; -.
DR   InParanoid; A8HYP5; -.
DR   OrthoDB; 1439483at2759; -.
DR   GO; GO:0030991; C:intraciliary transport particle A; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   InterPro; IPR029302; IFT43.
DR   PANTHER; PTHR33724; PTHR33724; 1.
DR   Pfam; PF15305; IFT43; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation.
FT   CHAIN           1..272
FT                   /note="Intraflagellar transport protein 43"
FT                   /id="PRO_0000409499"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..259
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   272 AA;  28816 MW;  A4D7920A46F0CB3A CRC64;
     MDDDAPKAAP KAGRRAARTA NTWGDDSAAP PEPQKGGFGL DSGFGGGGGS PRGNAFGAED
     SAPPKHVAST NFAPSGDDEP APAPSRQRTG DASGDRPSRG GAPPSRPPPA EILGEDSKKF
     VGVSRRKQEQ LARGDDEVSR KNLKYETLTA GVDGIMEIPE LEEEGREDLS NIVAEAPKVR
     TNKVQGMEEL EEDMHYKLPA MDDRDIDLSL LTAVLCSSEQ VAEAEDPWDP DIVLTEVASA
     INAEREKAEG GEAPDDMGGM RDEQGMPMPI KL