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IFT43_TAEGU
ID   IFT43_TAEGU             Reviewed;         204 AA.
AC   B5G1P1; B5G1N8; B5G1P0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Intraflagellar transport protein 43 homolog;
GN   Name=IFT43;
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA   Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA   Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA   Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA   Hayashizaki Y., Carninci P., Jarvis E.D.;
RT   "A molecular neuroethological approach for identifying and characterizing a
RT   cascade of behaviorally regulated genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
CC   -!- FUNCTION: As a component of IFT complex A (IFT-A), a complex required
CC       for retrograde ciliary transport and entry into cilia of G protein-
CC       coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in
CC       retrograde ciliary transport along microtubules from the ciliary tip to
CC       the base. {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBUNIT: Component of the IFT complex A (IFT-A) complex.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q96FT9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96FT9}. Note=Associated with microtubules.
CC       Localized at the distal tip of the cilium.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SIMILARITY: Belongs to the IFT43 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACH45201.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DQ215670; ACH45199.1; -; mRNA.
DR   EMBL; DQ215671; ACH45200.1; -; mRNA.
DR   EMBL; DQ215672; ACH45201.1; ALT_INIT; mRNA.
DR   EMBL; DQ215673; ACH45202.1; -; mRNA.
DR   RefSeq; NP_001232603.1; NM_001245674.1.
DR   AlphaFoldDB; B5G1P1; -.
DR   STRING; 59729.ENSTGUP00000019541; -.
DR   GeneID; 100190405; -.
DR   KEGG; tgu:100190405; -.
DR   CTD; 112752; -.
DR   InParanoid; B5G1P1; -.
DR   OrthoDB; 1272229at2759; -.
DR   Proteomes; UP000007754; Unplaced.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR   InterPro; IPR029302; IFT43.
DR   PANTHER; PTHR33724; PTHR33724; 1.
DR   Pfam; PF15305; IFT43; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..204
FT                   /note="Intraflagellar transport protein 43 homolog"
FT                   /id="PRO_0000409495"
FT   REGION          1..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        45
FT                   /note="S -> C (in Ref. 1; ACH45202)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  22785 MW;  D307FA61880B0B29 CRC64;
     MEAEPERAEA PRRGGVAAVL KMGRRARQDI FAGENLSRKN SPSASLGEVP PPKPPRRQGG
     WADDPVLAPT KSGRKHAEEV EDHRLRQQSL EASDDGGDIP VIPDLEDVQD EDLAMQVAAP
     PSVQVNRVLT YHDLDKDLMK YAAFQTLDGE VDLKLLTKVL APEHELREDD VSWDWDHLFT
     EVSSELVTEW DLGQSEREDH ISLP
 
 
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