ID   IFT43_XENLA             Reviewed;         201 AA.
AC   Q3B8E9; A0A1L8F9B0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Intraflagellar transport protein 43 homolog;
GN   Name=ift43;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|Proteomes:UP000186698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000312|Proteomes:UP000186698};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of IFT complex A (IFT-A), a complex required
CC       for retrograde ciliary transport and entry into cilia of G protein-
CC       coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in
CC       retrograde ciliary transport along microtubules from the ciliary tip to
CC       the base. {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBUNIT: Component of the IFT complex A (IFT-A) complex.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q96FT9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96FT9}. Note=Associated with microtubules.
CC       Localized at the distal tip of the cilium.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SIMILARITY: Belongs to the IFT43 family. {ECO:0000305}.
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DR   EMBL; CM004480; OCT68172.1; -; Genomic_DNA.
DR   EMBL; BC106504; AAI06505.1; -; mRNA.
DR   RefSeq; NP_001089762.1; NM_001096293.1.
DR   AlphaFoldDB; Q3B8E9; -.
DR   STRING; 8355.A0A1L8F9B0; -.
DR   MaxQB; Q3B8E9; -.
DR   DNASU; 734826; -.
DR   GeneID; 734826; -.
DR   KEGG; xla:734826; -.
DR   CTD; 734826; -.
DR   Xenbase; XB-GENE-5909289; ift43.L.
DR   OMA; XDGEIDL; -.
DR   OrthoDB; 1272229at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734826; Expressed in testis and 19 other tissues.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR   InterPro; IPR029302; IFT43.
DR   PANTHER; PTHR33724; PTHR33724; 1.
DR   Pfam; PF15305; IFT43; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="Intraflagellar transport protein 43 homolog"
FT                   /id="PRO_0000254043"
FT   REGION          1..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..104
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  22648 MW;  CD05D5E51E74C031 CRC64;
     MEDVLDLGEA PSRRTGVKMG RRARAAQETQ QETADVSRNQ TGREGPPKPL RQGGWADDSS
     GPSKSTRRMT DDVEDSRLKQ QSLDESDEGE DIPVIPDLED VQEEDLALQV ASPPSVQVNR
     VMTYRDLDND LMRHAAFQSL DGDVDLKLLT KVLSPEPEVR EENVRWDWDL LFTEVSSELI
     TEWDVGKMEK EDMLKPSPLV S