ID   IFT43_XENTR             Reviewed;         201 AA.
AC   Q28CW2; B0JYZ7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Intraflagellar transport protein 43 homolog;
GN   Name=ift43; ORFNames=TNeu143e16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of IFT complex A (IFT-A), a complex required
CC       for retrograde ciliary transport and entry into cilia of G protein-
CC       coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in
CC       retrograde ciliary transport along microtubules from the ciliary tip to
CC       the base. {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBUNIT: Component of the IFT complex A (IFT-A) complex.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q96FT9}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9DA69}. Note=Associated with microtubules.
CC       {ECO:0000250|UniProtKB:Q96FT9}.
CC   -!- SIMILARITY: Belongs to the IFT43 family. {ECO:0000305}.
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DR   EMBL; CR926158; CAJ82762.1; -; mRNA.
DR   EMBL; BC158978; AAI58979.1; -; mRNA.
DR   RefSeq; NP_001016535.1; NM_001016535.1.
DR   AlphaFoldDB; Q28CW2; -.
DR   STRING; 8364.ENSXETP00000028939; -.
DR   PaxDb; Q28CW2; -.
DR   Ensembl; ENSXETT00000028939; ENSXETP00000028939; ENSXETG00000013218.
DR   GeneID; 549289; -.
DR   KEGG; xtr:549289; -.
DR   CTD; 112752; -.
DR   Xenbase; XB-GENE-5909249; ift43.
DR   eggNOG; ENOG502RXJ2; Eukaryota.
DR   HOGENOM; CLU_104337_0_0_1; -.
DR   InParanoid; Q28CW2; -.
DR   OMA; XDGEIDL; -.
DR   OrthoDB; 1272229at2759; -.
DR   PhylomeDB; Q28CW2; -.
DR   TreeFam; TF323566; -.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013218; Expressed in testis and 13 other tissues.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR   InterPro; IPR029302; IFT43.
DR   PANTHER; PTHR33724; PTHR33724; 1.
DR   Pfam; PF15305; IFT43; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="Intraflagellar transport protein 43 homolog"
FT                   /id="PRO_0000254044"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  22571 MW;  C19893C2AA7304AE CRC64;
     MEDVLDLGEA PSRRSGVKMG RRARASQENQ QETADASRNQ PGREGPPKPL RQGGWADDSS
     GPSKSTKRMT EDVEDSRLKQ QSLDESDEGE DIPVIPDLED VQEEDLALQV ASPPSVQVNR
     VLTYKDLDND LMRHAAFQTL DGDIDLKLLT KVLSPEPEVR EENVQWDWDL LFTEVSSELI
     TEWDVGKMEK EDMLKPSPLV S