ID   IFT46_BOVIN             Reviewed;         301 AA.
AC   Q1LZB4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Intraflagellar transport protein 46 homolog;
GN   Name=IFT46;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms part of a complex involved in intraflagellar transport
CC       (IFT), the bi-directional movement of particles required for the
CC       assembly, maintenance and functioning of primary cilia. May play a role
CC       in chondrocyte maturation and skeletogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC       IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74,
CC       IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1.
CC       Interacts with ARL13B. Interacts with TTC26/IFT56 (By similarity).
CC       Interacts with TTC25 (By similarity). Interacts with TTC30B (By
CC       similarity). {ECO:0000250|UniProtKB:Q9DB07,
CC       ECO:0000250|UniProtKB:Q9NQC8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Expression
CC       is concentrated at the cilium basal body but is also detected along the
CC       length of the cilium. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IFT46 family. {ECO:0000305}.
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DR   EMBL; BC116107; AAI16108.1; -; mRNA.
DR   RefSeq; NP_001068677.1; NM_001075209.1.
DR   AlphaFoldDB; Q1LZB4; -.
DR   SMR; Q1LZB4; -.
DR   STRING; 9913.ENSBTAP00000017195; -.
DR   PaxDb; Q1LZB4; -.
DR   Ensembl; ENSBTAT00000017195; ENSBTAP00000017195; ENSBTAG00000012941.
DR   GeneID; 505579; -.
DR   KEGG; bta:505579; -.
DR   CTD; 56912; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012941; -.
DR   VGNC; VGNC:30069; IFT46.
DR   eggNOG; ENOG502QPNA; Eukaryota.
DR   GeneTree; ENSGT00390000005544; -.
DR   HOGENOM; CLU_039364_1_0_1; -.
DR   InParanoid; Q1LZB4; -.
DR   OMA; HRFKPPA; -.
DR   OrthoDB; 878878at2759; -.
DR   TreeFam; TF314221; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000012941; Expressed in oviduct epithelium and 107 other tissues.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   InterPro; IPR022088; Intraflagellar_transp_cmplxB.
DR   PANTHER; PTHR13376; PTHR13376; 1.
DR   Pfam; PF12317; IFT46_B_C; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..301
FT                   /note="Intraflagellar transport protein 46 homolog"
FT                   /id="PRO_0000249461"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..55
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         283
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DB07"
SQ   SEQUENCE   301 AA;  33922 MW;  E0E75A1632CF1512 CRC64;
     MADNSSDEYE DENNKEKKKT SQLTPQRGFS ENDDDDDDDD SSETDSDDDD EEHGAPLEGA
     YDPADYEHLP VSAEVKELFQ YISRYTPQLI DLDHKLKPFI PDFIPAVGDI DAFLKVPRPD
     GKPDNLGLLV LDEPSTKQSD PTVLSLWLTE NSKQHNITQH MKVKSLEDAE KNPKAIDTWI
     ESISELHRSK PPATVHYTRP MPDIDTLMQE WSPEFEELLG KVSLPTAEID CSLAEYIDMI
     CAILDIPVYK SRIQSLHLLF SLYSEFKNSQ HFKALAEGKT AFTPPSNSNS QAGDAETLTF
     S