ID   IFT46_RAT               Reviewed;         301 AA.
AC   Q6AXQ9; Q4V7E9;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Intraflagellar transport protein 46 homolog;
GN   Name=Ift46;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Forms part of a complex involved in intraflagellar transport
CC       (IFT), the bi-directional movement of particles required for the
CC       assembly, maintenance and functioning of primary cilia. May play a role
CC       in chondrocyte maturation and skeletogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC       IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74,
CC       IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1.
CC       Interacts with ARL13B. Interacts with TTC26/IFT56 (By similarity).
CC       Interacts with TTC25 (By similarity). Interacts with TTC30B (By
CC       similarity). {ECO:0000250|UniProtKB:Q9DB07,
CC       ECO:0000250|UniProtKB:Q9NQC8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Expression
CC       is concentrated at the cilium basal body but is also detected along the
CC       length of the cilium. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IFT46 family. {ECO:0000305}.
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DR   EMBL; BC079388; AAH79388.2; -; mRNA.
DR   EMBL; BC097954; AAH97954.1; -; mRNA.
DR   RefSeq; NP_001019931.1; NM_001024760.1.
DR   RefSeq; XP_006242992.1; XM_006242930.3.
DR   RefSeq; XP_006242993.1; XM_006242931.3.
DR   RefSeq; XP_017451042.1; XM_017595553.1.
DR   AlphaFoldDB; Q6AXQ9; -.
DR   SMR; Q6AXQ9; -.
DR   STRING; 10116.ENSRNOP00000019011; -.
DR   iPTMnet; Q6AXQ9; -.
DR   PhosphoSitePlus; Q6AXQ9; -.
DR   jPOST; Q6AXQ9; -.
DR   PaxDb; Q6AXQ9; -.
DR   GeneID; 300675; -.
DR   KEGG; rno:300675; -.
DR   UCSC; RGD:1307682; rat.
DR   CTD; 56912; -.
DR   RGD; 1307682; Ift46.
DR   VEuPathDB; HostDB:ENSRNOG00000013919; -.
DR   eggNOG; ENOG502QPNA; Eukaryota.
DR   InParanoid; Q6AXQ9; -.
DR   OMA; HRFKPPA; -.
DR   OrthoDB; 878878at2759; -.
DR   PhylomeDB; Q6AXQ9; -.
DR   TreeFam; TF314221; -.
DR   Reactome; R-RNO-5620924; Intraflagellar transport.
DR   PRO; PR:Q6AXQ9; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000013919; Expressed in testis and 20 other tissues.
DR   Genevisible; Q6AXQ9; RN.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   InterPro; IPR022088; Intraflagellar_transp_cmplxB.
DR   PANTHER; PTHR13376; PTHR13376; 1.
DR   Pfam; PF12317; IFT46_B_C; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..301
FT                   /note="Intraflagellar transport protein 46 homolog"
FT                   /id="PRO_0000085518"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..55
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         283
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DB07"
SQ   SEQUENCE   301 AA;  34032 MW;  84ACB6A2863C9387 CRC64;
     MADNSSDEYE EDNKEKKKPS QLTPQQGFSE NDDDDDDDSS ETDSDDDDDD EEHGAPLEGA
     YDPADYEHLP VSAEIKELFE YISRYTPQLI DLDHKLKPFI PDFIPAVGDI DAFLKVPRPD
     GKPDHLGLLV LDEPSTKQSD PTVLSLWLTE NSKQHNITQH MKVKSLEDAE KNPKAIDTWI
     ESISELHRSK PPATVHYTRP MPDIDTLMQE WSPEFEELLG KVSLPTVEID CSLAEYIDMI
     CAILDIPFYK SRIQSLHLLF SLYSEFKNSQ HFKALAEGKK TFTPPSNSAS QAGDAETLSF
     L