IFT56_CAEEL
ID IFT56_CAEEL Reviewed; 574 AA.
AC Q95QT8; Q8MQB6;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Intraflagellar transport protein 56 homolog {ECO:0000250|UniProtKB:Q5PR66};
DE AltName: Full=Abnormal dye filling protein 13 {ECO:0000303|PubMed:7705621};
GN Name=dyf-13 {ECO:0000303|PubMed:7705621, ECO:0000312|WormBase:C27H5.7a};
GN ORFNames=C27H5.7 {ECO:0000312|WormBase:C27H5.7a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GENE NAME.
RX PubMed=7705621; DOI=10.1093/genetics/139.1.171;
RA Starich T.A., Herman R.K., Kari C.K., Yeh W.H., Schackwitz W.S.,
RA Schuyler M.W., Collet J., Thomas J.H., Riddle D.L.;
RT "Mutations affecting the chemosensory neurons of Caenorhabditis elegans.";
RL Genetics 139:171-188(1995).
RN [3]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=15916950; DOI=10.1016/j.cub.2005.04.059;
RA Blacque O.E., Perens E.A., Boroevich K.A., Inglis P.N., Li C., Warner A.,
RA Khattra J., Holt R.A., Ou G., Mah A.K., McKay S.J., Huang P., Swoboda P.,
RA Jones S.J.M., Marra M.A., Baillie D.L., Moerman D.G., Shaham S.,
RA Leroux M.R.;
RT "Functional genomics of the cilium, a sensory organelle.";
RL Curr. Biol. 15:935-941(2005).
RN [4]
RP FUNCTION, IDENTIFICATION IN IFT COMPLEX B, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=28479320; DOI=10.1016/j.cub.2017.04.015;
RA Yi P., Li W.J., Dong M.Q., Ou G.;
RT "Dynein-driven retrograde intraflagellar transport is triphasic in C.
RT elegans sensory cilia.";
RL Curr. Biol. 27:1448-1461(2017).
CC -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B
CC required for transport of proteins in the motile cilium
CC (PubMed:28479320, PubMed:15916950). May be required for ciliary
CC entrance and transport of specific ciliary cargo proteins such as che-3
CC which are related to motility (PubMed:28479320).
CC {ECO:0000269|PubMed:28479320, ECO:0000305|PubMed:15916950}.
CC -!- SUBUNIT: Component of the IFT complex B composed of at least che-2,
CC che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81,
CC ifta-2, osm-1, osm-5 and osm-6. {ECO:0000269|PubMed:28479320}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q5PR66}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q95QT8-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q95QT8-2; Sequence=VSP_057361;
CC -!- DISRUPTION PHENOTYPE: Structural cilia defect: cilia are short and lack
CC distal portions. {ECO:0000269|PubMed:15916950}.
CC -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
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DR EMBL; FO080695; CCD65894.1; -; Genomic_DNA.
DR EMBL; FO080695; CCD65895.1; -; Genomic_DNA.
DR RefSeq; NP_741021.1; NM_171019.1. [Q95QT8-1]
DR RefSeq; NP_741022.1; NM_171020.4. [Q95QT8-2]
DR AlphaFoldDB; Q95QT8; -.
DR SMR; Q95QT8; -.
DR ComplexPortal; CPX-1290; Intraflagellar transport complex B.
DR STRING; 6239.C27H5.7a; -.
DR PaxDb; Q95QT8; -.
DR PRIDE; Q95QT8; -.
DR EnsemblMetazoa; C27H5.7a.1; C27H5.7a.1; WBGene00001129. [Q95QT8-1]
DR EnsemblMetazoa; C27H5.7b.1; C27H5.7b.1; WBGene00001129. [Q95QT8-2]
DR GeneID; 182970; -.
DR KEGG; cel:CELE_C27H5.7; -.
DR UCSC; C27H5.7b.1; c. elegans.
DR CTD; 182970; -.
DR WormBase; C27H5.7a; CE06894; WBGene00001129; dyf-13. [Q95QT8-1]
DR WormBase; C27H5.7b; CE31320; WBGene00001129; dyf-13. [Q95QT8-2]
DR eggNOG; KOG3785; Eukaryota.
DR GeneTree; ENSGT00390000000159; -.
DR InParanoid; Q95QT8; -.
DR OMA; FIIRRDY; -.
DR OrthoDB; 383516at2759; -.
DR PhylomeDB; Q95QT8; -.
DR Reactome; R-CEL-5620924; Intraflagellar transport.
DR PRO; PR:Q95QT8; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00001129; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR GO; GO:0005929; C:cilium; IC:ComplexPortal.
DR GO; GO:0030992; C:intraciliary transport particle B; IBA:GO_Central.
DR GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR GO; GO:0035720; P:intraciliary anterograde transport; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; IC:ComplexPortal.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR030511; TTC26.
DR PANTHER; PTHR14781; PTHR14781; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Protein transport;
KW Reference proteome; Repeat; TPR repeat; Transport.
FT CHAIN 1..574
FT /note="Intraflagellar transport protein 56 homolog"
FT /id="PRO_0000431683"
FT REPEAT 20..52
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 57..90
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 151..184
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..22
FT /note="Missing (in isoform b)"
FT /id="VSP_057361"
SQ SEQUENCE 574 AA; 66194 MW; 59C4EF2C42839D6E CRC64;
MLNLFRNRKR NGAGPTIKKA QKMPELDDFL SNQDYEGAIS LLNHKLKAGN LDREEEDSLQ
LWLAHCYYRL RNYEEAANVY TFLMNKDDAP AELGVYLACC KFYLKQYIEA KSIAEKCPKT
PLCIRLMMNV SLRLNDEKRI LTFHSSLGDT LEDRLSLAGV NYSRMHYQDA IEVYTSVLQT
SPNLIGLNVN MALCYAKMDY PHVAYNLIKN YLRNFPNSPF AKNLLLSVLY RTITSKTTVD
EKSELARNID QEGLTMVSDM EALLKQKLYP EIEYICKHNL VLFKNCETAL QVLPSLMKHI
PEARVNLILY HLNKNNVKDA ISLCKDFDPV TPYEFLVKAL TFLRHGQETN SREHLKIAEN
FFQMVGESGL VQDTIAGRQS SAAYLFLSFK FDDVITYLKS IEAYFTNNDD FLLNLAQAYL
MYKNYVAAEK LFIRVSGPER DKILYKSMLA RCYVRNKKPQ SAWDMMLKTN NPSDRMSLLK
VIAQDCYIAN EFYYASKAFH EIEISDPTTE NWSGKRGACA GLFRQLANHK TDPILISQMR
EVVHLVAMKP HSNCEFLLKV VRNWAETHNV NIIN
