IFT56_CHLRE
ID IFT56_CHLRE Reviewed; 555 AA.
AC A8JA42;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Intraflagellar transport protein 56 {ECO:0000303|PubMed:24596149};
DE AltName: Full=Abnormal dye filling protein 13 {ECO:0000250|UniProtKB:Q95QT8};
DE AltName: Full=Tetratricopeptide repeat protein 26 homolog;
DE Short=TPR repeat protein 26 homolog;
GN Name=DYF13 {ECO:0000303|PubMed:24596149};
GN Synonyms=IFT56 {ECO:0000303|PubMed:24596149};
GN ORFNames=CHLREDRAFT_81760 {ECO:0000312|EMBL:EDO99269.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE IFT COMPLEX B, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=24596149; DOI=10.7554/elife.01566;
RA Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H.,
RA Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R.,
RA Marshall W.F.;
RT "TTC26/DYF13 is an intraflagellar transport protein required for transport
RT of motility-related proteins into flagella.";
RL Elife 3:E01566-E01566(2014).
RN [3]
RP ERRATUM OF PUBMED:24596149.
RX PubMed=24692455; DOI=10.7554/elife.02897;
RA Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H.,
RA Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R.,
RA Marshall W.F.;
RL Elife 3:E02897-E02897(2014).
CC -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B
CC required for transport of proteins in the motile cilium. Required for
CC transport of specific ciliary cargo proteins related to motility, while
CC it is neither required for IFT complex B assembly or motion nor for
CC cilium assembly. {ECO:0000269|PubMed:24596149}.
CC -!- SUBUNIT: Component of the IFT complex B. {ECO:0000269|PubMed:24596149}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:24596149}.
CC -!- DISRUPTION PHENOTYPE: Flagella motility defects.
CC {ECO:0000269|PubMed:24596149}.
CC -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
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DR EMBL; DS496148; EDO99269.1; -; Genomic_DNA.
DR RefSeq; XP_001698769.1; XM_001698717.1.
DR AlphaFoldDB; A8JA42; -.
DR SMR; A8JA42; -.
DR STRING; 3055.EDO99269; -.
DR PaxDb; A8JA42; -.
DR PRIDE; A8JA42; -.
DR GeneID; 5724373; -.
DR eggNOG; KOG3785; Eukaryota.
DR HOGENOM; CLU_036306_2_0_1; -.
DR InParanoid; A8JA42; -.
DR OrthoDB; 383516at2759; -.
DR GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0042073; P:intraciliary transport; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR030511; TTC26.
DR PANTHER; PTHR14781; PTHR14781; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Flagellum; Protein transport; Repeat; TPR repeat;
KW Transport.
FT CHAIN 1..555
FT /note="Intraflagellar transport protein 56"
FT /id="PRO_0000431684"
FT REPEAT 57..90
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 151..184
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 393..426
FT /note="TPR 3"
FT /evidence="ECO:0000255"
SQ SEQUENCE 555 AA; 63404 MW; 8609D6B4F187F118 CRC64;
MFYSKSRPQH AARTNVAQAA ANEKPKVPEL EEFLTKRDYL GAIALLSFRR HANRNDLKNL
EWLAYCYFHY GEHDKALVIY KELLQHEDPD PMFFVYSAAC LYYMGMYKEA EEQALQGPKC
ALQTRILFHS AQRQGNDDKL MAYHGQLTDS IEDQLTLASI HYQRSHFQEA TDIYKRLLLE
HRDYLRSTVV YVALCYCKLD YYDVSLEILG VYLSAFPDSA IAVNLKACNH FRMYNGKAAE
AELKTLAELS GGQHLDHDLI RHNLVVFRGG ENALQVLPPL SDIPPEARLN LVIHHLRHHE
VGEAFGLIKD MEPSTPPEFI LKAVVHAMLG QVKGDPEHLK KAQQYYQLVG ASASECDTIP
GRQCMASCFF LLKQFEDVLV FLSSIKTYFL NDDDFNWNLG IAKAATGKYK EAEETLLQIA
NDKYRNEYTY TSWLARCYIM NGKARLAWER YLQLETNDES YQLLLLIAND CYKMGAFYFA
CKAFDVLERL DPAPEYLEGK KGAACGAFQM IVAGKEPKDL LRDVISLLRG NNSADQCEPI
VAVMRKWAKN NGVKL
