ID   IFT56_MACFA             Reviewed;         554 AA.
AC   Q4R7Z9; Q4R6T1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Intraflagellar transport protein 56 {ECO:0000250|UniProtKB:Q8BS45};
DE   AltName: Full=Tetratricopeptide repeat protein 26;
DE            Short=TPR repeat protein 26;
GN   Name=TTC26; Synonyms=IFT56 {ECO:0000250|UniProtKB:Q8BS45};
GN   ORFNames=QtsA-13939, QtsA-17174;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B
CC       required for transport of proteins in the motile cilium. Required for
CC       transport of specific ciliary cargo proteins related to motility, while
CC       it is neither required for IFT complex B assembly or motion nor for
CC       cilium assembly. Required for efficient coupling between the
CC       accumulation of GLI2 and GLI3 at the ciliary tips and their
CC       dissociation from the negative regulator SUFU. Plays a key role in
CC       maintaining the integrity of the IFT complex B and the proper ciliary
CC       localization of the IFT complex B components. Not required for IFT
CC       complex A ciliary localization or function. Essential for maintaining
CC       proper microtubule organization within the ciliary axoneme.
CC       {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SUBUNIT: Component of the IFT complex B. Interacts with IFT46; the
CC       interaction is direct. {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8BS45}. Note=Localizes at the base to the
CC       ciliary transition zone. {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
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DR   EMBL; AB168662; BAE00773.1; -; mRNA.
DR   EMBL; AB169099; BAE01193.1; -; mRNA.
DR   RefSeq; NP_001270883.1; NM_001283954.1.
DR   AlphaFoldDB; Q4R7Z9; -.
DR   SMR; Q4R7Z9; -.
DR   STRING; 9541.XP_005550961.1; -.
DR   Ensembl; ENSMFAT00000033710; ENSMFAP00000025559; ENSMFAG00000044086.
DR   Ensembl; ENSMFAT00000084013; ENSMFAP00000055582; ENSMFAG00000044086.
DR   GeneID; 101865587; -.
DR   CTD; 79989; -.
DR   VEuPathDB; HostDB:ENSMFAG00000044086; -.
DR   eggNOG; KOG3785; Eukaryota.
DR   GeneTree; ENSGT00390000000159; -.
DR   OMA; FIIRRDY; -.
DR   OrthoDB; 383516at2759; -.
DR   Proteomes; UP000233100; Chromosome 3.
DR   Bgee; ENSMFAG00000044086; Expressed in pituitary gland and 10 other tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IEA:Ensembl.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:1905198; P:manchette assembly; IEA:Ensembl.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR030511; TTC26.
DR   PANTHER; PTHR14781; PTHR14781; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Protein transport; Reference proteome; Repeat;
KW   TPR repeat; Transport.
FT   CHAIN           1..554
FT                   /note="Intraflagellar transport protein 56"
FT                   /id="PRO_0000289083"
FT   REPEAT          57..90
FT                   /note="TPR 1"
FT   REPEAT          92..125
FT                   /note="TPR 2"
FT   REPEAT          151..184
FT                   /note="TPR 3"
FT   REPEAT          468..501
FT                   /note="TPR 4"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        161
FT                   /note="H -> N (in Ref. 1; BAE01193)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        308
FT                   /note="I -> T (in Ref. 1; BAE01193)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   554 AA;  64106 MW;  83634601641704E3 CRC64;
     MMLSRAKPAV GRGVQPTDKK KKKGRKIPKL EELLSKRDFT GAITLLEFKR HVGEEEEDTN
     LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT YFFLGMYKQA EAAGFKASKS
     RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV TEDQLSLASI HYMRSHYQEA IDIYKRILLD
     NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA
     ELKSLMDNAS SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
     VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP
     GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEAFLLIQ
     SEKMKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKMGQFYYS
     AKAFDVLERL DPNPEYWEGK RGACVGIFQM IVAGREPKET LREVLHLLRS TGNTQVEYMI
     RIMKKWAKEN RVPI