IFT56_RAT
ID IFT56_RAT Reviewed; 554 AA.
AC Q5U2N8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Intraflagellar transport protein 56 {ECO:0000250|UniProtKB:Q8BS45};
DE AltName: Full=Tetratricopeptide repeat protein 26 {ECO:0000312|RGD:1561363};
DE Short=TPR repeat protein 26;
GN Name=Ttc26 {ECO:0000312|RGD:1561363};
GN Synonyms=Ift56 {ECO:0000250|UniProtKB:Q8BS45};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=22718903; DOI=10.1091/mbc.e12-01-0019;
RA Zhang Q., Liu Q., Austin C., Drummond I., Pierce E.A.;
RT "Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and
RT the pronephros in zebrafish.";
RL Mol. Biol. Cell 23:3069-3078(2012).
CC -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B
CC required for transport of proteins in the motile cilium. Required for
CC transport of specific ciliary cargo proteins related to motility, while
CC it is neither required for IFT complex B assembly or motion nor for
CC cilium assembly. Required for efficient coupling between the
CC accumulation of GLI2 and GLI3 at the ciliary tips and their
CC dissociation from the negative regulator SUFU. Plays a key role in
CC maintaining the integrity of the IFT complex B and the proper ciliary
CC localization of the IFT complex B components. Not required for IFT
CC complex A ciliary localization or function. Essential for maintaining
CC proper microtubule organization within the ciliary axoneme.
CC {ECO:0000250|UniProtKB:Q8BS45}.
CC -!- SUBUNIT: Component of the IFT complex B. Interacts with IFT46; the
CC interaction is direct. {ECO:0000250|UniProtKB:Q8BS45}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:22718903}. Note=Localizes at the transition zone in
CC photoreceptor cells. {ECO:0000250|UniProtKB:Q8BS45}.
CC -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
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DR EMBL; BC085935; AAH85935.1; -; mRNA.
DR RefSeq; NP_001020216.1; NM_001025045.1.
DR AlphaFoldDB; Q5U2N8; -.
DR SMR; Q5U2N8; -.
DR STRING; 10116.ENSRNOP00000034588; -.
DR iPTMnet; Q5U2N8; -.
DR PhosphoSitePlus; Q5U2N8; -.
DR PaxDb; Q5U2N8; -.
DR Ensembl; ENSRNOT00000031193; ENSRNOP00000034588; ENSRNOG00000027617.
DR GeneID; 500086; -.
DR KEGG; rno:500086; -.
DR UCSC; RGD:1561363; rat.
DR CTD; 79989; -.
DR RGD; 1561363; Ttc26.
DR eggNOG; KOG3785; Eukaryota.
DR GeneTree; ENSGT00390000000159; -.
DR HOGENOM; CLU_036306_2_0_1; -.
DR InParanoid; Q5U2N8; -.
DR OMA; FIIRRDY; -.
DR OrthoDB; 383516at2759; -.
DR PhylomeDB; Q5U2N8; -.
DR Reactome; R-RNO-5620924; Intraflagellar transport.
DR PRO; PR:Q5U2N8; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000027617; Expressed in testis and 18 other tissues.
DR Genevisible; Q5U2N8; RN.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0120170; F:intraciliary transport particle B binding; ISO:RGD.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0035720; P:intraciliary anterograde transport; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central.
DR GO; GO:1905198; P:manchette assembly; ISO:RGD.
DR GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0007286; P:spermatid development; ISO:RGD.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR030511; TTC26.
DR PANTHER; PTHR14781; PTHR14781; 1.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Protein transport; Reference proteome; Repeat;
KW TPR repeat; Transport.
FT CHAIN 1..554
FT /note="Intraflagellar transport protein 56"
FT /id="PRO_0000289085"
FT REPEAT 57..90
FT /note="TPR 1"
FT REPEAT 92..125
FT /note="TPR 2"
FT REPEAT 151..184
FT /note="TPR 3"
FT REPEAT 468..501
FT /note="TPR 4"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 64135 MW; 10F5B8AC8B747A40 CRC64;
MMLSRAKPAV GGESPHTDKR KKKGRKIPKL EDLLSQRDFT GAITLLEFKR HVGEQEEDTN
LWIGYCAFHL GDYKRALEEY ENAAKEENCN PEVWVNLACT YFFLGMYKQA EAAGFKAPKS
RLQNRLLFHL AHKFNDEKKL MNFHQNLQDI KEDQLSLASI HYMRSHYQEA IDIYKRILLD
NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGKAAEA
ELKSLMDNAS SPFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP
GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEVFLLIQ
SEKLKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKMGQFYYS
AKAFDVLERL DPNPEYWEGK RGACVGIFQM ILAGREPKET LREVLHLLRS TGNTQVEYII
RIMKKWAKEN RVPI
