ID   IFT56_TRYB2             Reviewed;         566 AA.
AC   Q57ZL2; D6XDK7;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Intraflagellar transport protein 56 homolog {ECO:0000250|UniProtKB:Q5PR66};
DE   AltName: Full=Putative IFT protein C3 {ECO:0000303|PubMed:18094047};
GN   Name=PIFTC3 {ECO:0000303|PubMed:18094047};
GN   and
GN   ORFNames=Tb927.3.3000 {ECO:0000312|EMBL:AAX79470.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000312|Proteomes:UP000008524};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000312|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [2]
RP   GENE NAME, AND DISRUPTION PHENOTYPE.
RX   PubMed=18094047; DOI=10.1091/mbc.e07-08-0749;
RA   Absalon S., Blisnick T., Kohl L., Toutirais G., Dore G., Julkowska D.,
RA   Tavenet A., Bastin P.;
RT   "Intraflagellar transport and functional analysis of genes required for
RT   flagellum formation in trypanosomes.";
RL   Mol. Biol. Cell 19:929-944(2008).
RN   [3]
RP   FUNCTION, AND IDENTIFICATION IN THE IFT COMPLEX.
RX   PubMed=20923419; DOI=10.1111/j.1365-2958.2010.07322.x;
RA   Franklin J.B., Ullu E.;
RT   "Biochemical analysis of PIFTC3, the Trypanosoma brucei orthologue of
RT   nematode DYF-13, reveals interactions with established and putative
RT   intraflagellar transport components.";
RL   Mol. Microbiol. 78:173-186(2010).
CC   -!- FUNCTION: Component of the intraflagellar transport (IFT) complex
CC       required for transport of proteins in the motile cilium.
CC       {ECO:0000305|PubMed:20923419}.
CC   -!- SUBUNIT: Component of the IFT complex B. {ECO:0000250|UniProtKB:A8JA42,
CC       ECO:0000305|PubMed:20923419}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000269|PubMed:20923419}. Note=Localizes around the basal bodies
CC       and the flagellum base. {ECO:0000269|PubMed:20923419}.
CC   -!- DISRUPTION PHENOTYPE: Defects in new flagellum formation.
CC       {ECO:0000269|PubMed:18094047}.
CC   -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
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DR   EMBL; AC104642; AAX79470.1; -; Genomic_DNA.
DR   EMBL; CP000066; AAZ10334.1; -; Genomic_DNA.
DR   RefSeq; XP_843893.1; XM_838800.1.
DR   AlphaFoldDB; Q57ZL2; -.
DR   SMR; Q57ZL2; -.
DR   STRING; 5691.AAZ10334; -.
DR   PaxDb; Q57ZL2; -.
DR   PRIDE; Q57ZL2; -.
DR   GeneID; 3656238; -.
DR   KEGG; tbr:Tb927.3.3000; -.
DR   VEuPathDB; TriTrypDB:Tb927.3.3000; -.
DR   eggNOG; KOG3785; Eukaryota.
DR   InParanoid; Q57ZL2; -.
DR   OMA; FIIRRDY; -.
DR   Proteomes; UP000008524; Chromosome 3.
DR   GO; GO:0036064; C:ciliary basal body; IDA:GeneDB.
DR   GO; GO:0097546; C:ciliary base; IDA:GeneDB.
DR   GO; GO:0030990; C:intraciliary transport particle; IDA:GeneDB.
DR   GO; GO:0030992; C:intraciliary transport particle B; IDA:GeneDB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0035720; P:intraciliary anterograde transport; IMP:GeneDB.
DR   GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IMP:GeneDB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR030511; TTC26.
DR   PANTHER; PTHR14781; PTHR14781; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Flagellum; Protein transport; Reference proteome;
KW   Repeat; TPR repeat; Transport.
FT   CHAIN           1..566
FT                   /note="Intraflagellar transport protein 56 homolog"
FT                   /id="PRO_0000431685"
FT   REPEAT          59..92
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          94..126
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          153..186
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   566 AA;  64892 MW;  1C8C9387421C34A7 CRC64;
     MLSTSGRVKR KNAAPLQKVG QTKTSVVDQL EEALQQRDFS KATTVLEFYK TTNQPVGDLP
     INPWLAYSAF HMNDVSKALD VYKELLSLDG CDPMHYIHMG CCHFVNGSYA EAEECALKGP
     DCSLQTRLLF HIAQKTYDED KLLVYHQKLK ETVEDQLSLG AVHFYRGHFQ EAIDVYKRIL
     LETREYIALN VYVAMCYYKM DYYDVSLEVL NVYLQSHNNS ATAINLKSCN HYRLYNGKAA
     EAELRVLIDL QRSTYNVEND IVKHNLVVFR NGEDALQVLP PLLNVVPEAR LNLVIYHLRH
     EQIEEAYELI KDLEPVASTE YILKAVVNAF IGQKLDSEEH LKTTREYFNL IGSAQSECDT
     IPGRQCMASY FFILRDFPNV LIYLRSIKPY FLNDDTFLYL HGIACAATGS FAEAEESLTA
     VRSEKVKAEF SYMSWLMRAH IMNKHAKRAW DIYLKMETSA ESFNILQLMA NDCYKVCAFY
     YAAKAFDVLE RLDSAPEYIE GKKGACIGVF QQVFAGQEPA DSLFDVMKML DMSVQQHAND
     PKVSQQFESI LKVIKDWVKE SKLKKK