ID   IFT56_XENTR             Reviewed;         554 AA.
AC   A4III8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Intraflagellar transport protein 56 {ECO:0000250|UniProtKB:Q8BS45};
DE   AltName: Full=Tetratricopeptide repeat protein 26;
DE            Short=TPR repeat protein 26;
GN   Name=ttc26; Synonyms=ift56 {ECO:0000250|UniProtKB:Q8BS45};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B
CC       required for transport of proteins in the motile cilium. Required for
CC       transport of specific ciliary cargo proteins related to motility, while
CC       it is neither required for IFT complex B assembly or motion nor for
CC       cilium assembly. Plays a key role in maintaining the integrity of the
CC       IFT complex B and the proper ciliary localization of the IFT complex B
CC       components. Essential for maintaining proper microtubule organization
CC       within the ciliary axoneme. {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SUBUNIT: Component of the IFT complex B.
CC       {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8BS45}.
CC   -!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
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DR   EMBL; BC136035; AAI36036.1; -; mRNA.
DR   RefSeq; NP_001096401.1; NM_001102931.1.
DR   AlphaFoldDB; A4III8; -.
DR   SMR; A4III8; -.
DR   STRING; 8364.ENSXETP00000029419; -.
DR   PaxDb; A4III8; -.
DR   PRIDE; A4III8; -.
DR   DNASU; 100125003; -.
DR   GeneID; 100125003; -.
DR   KEGG; xtr:100125003; -.
DR   CTD; 79989; -.
DR   Xenbase; XB-GENE-1002214; ttc26.
DR   eggNOG; KOG3785; Eukaryota.
DR   HOGENOM; CLU_036306_2_0_1; -.
DR   InParanoid; A4III8; -.
DR   OrthoDB; 383516at2759; -.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; IBA:GO_Central.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0035720; P:intraciliary anterograde transport; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR030511; TTC26.
DR   PANTHER; PTHR14781; PTHR14781; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Protein transport; Reference proteome; Repeat;
KW   TPR repeat; Transport.
FT   CHAIN           1..554
FT                   /note="Intraflagellar transport protein 56"
FT                   /id="PRO_0000289087"
FT   REPEAT          57..90
FT                   /note="TPR 1"
FT   REPEAT          92..125
FT                   /note="TPR 2"
FT   REPEAT          151..184
FT                   /note="TPR 3"
FT   REPEAT          468..501
FT                   /note="TPR 4"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  63893 MW;  F1FDB7F844D58150 CRC64;
     MMLSRAKPAV GNEVQQIDKK KKKGKKVPRL DELLAQRDFT GAITLLEFKR QVGESEEDTE
     LWIGYCSFHL GDYKRSLEVF KALSQQEGCN PDVWVNLACT SFFLGMYKEA DEAANKAPKS
     RLQNRLLFHL AHKFNDEKRL MVFHQNLQDV IEDQLSLASI HYMRSHYQEA IDIYKRILLE
     NRDFLALNVY VALCYYKLDY YDVSQEVLAV YLQQVPDSTI ALNLKACNHF RLYNGKAAEA
     ELKGLMDSTS SPIEFAKELI KHNLVVFRAG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
     VQEAFNLIKD LEPSTPQEYI LKGVVNASLG QELGSRDHLK IAQQFFQLVG GSASECDTIP
     GRQCMASCFF LLRQFDDVLI YLNSIKSYFY NDDTFNFNYA QAKAAVGNYK EAEEVFLLIQ
     NEKIKNDYTY LSWLARCYIM NKKPRMAWEL YLKMETSGES FSLLQLIAND CYKMGHFYYA
     AKAFDILERL DPSPEYWEGK RGACVGIFQM ILAGREPKET LREVLNLLRS TGNTQVEYII
     RILKKWGKEN RVPV