ID   IFT57_CHLRE             Reviewed;         469 AA.
AC   Q2XQY7; A8I1V2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Intraflagellar transport protein 57;
GN   Name=IFT57; ORFNames=CHLREDRAFT_98642;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pazour G.J., Walker B.L., Rosenbaum J.L., Witman G.B., Cole D.G.;
RT   "Chlamydomonas intraflagellar transport protein IFT57.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503, and cw92;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [3]
RP   INTERACTION WITH THE INTRAFLAGELLAR TRANSPORT CORE B COMPLEX.
RX   PubMed=15955805; DOI=10.1074/jbc.m505062200;
RA   Lucker B.F., Behal R.H., Qin H., Siron L.C., Taggart W.D., Rosenbaum J.L.,
RA   Cole D.G.;
RT   "Characterization of the intraflagellar transport complex B core: direct
RT   interaction of the IFT81 and IFT74/72 subunits.";
RL   J. Biol. Chem. 280:27688-27696(2005).
CC   -!- FUNCTION: Required for the maintenance and formation of cilia.
CC   -!- SUBUNIT: Component of the IFT complex B, the core composed of IFT25,
CC       IFT27, IFT46, IFT52, IFT74, IFT81 and IFT88 as well as associated
CC       subunits IFT20, IFT57, IFT80 and IFT172.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium.
CC   -!- SIMILARITY: Belongs to the IFT57 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP08141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DQ266092; ABB72789.1; -; mRNA.
DR   EMBL; DS496111; EDP08141.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2XQY7; -.
DR   SMR; Q2XQY7; -.
DR   STRING; 3055.EDP08141; -.
DR   PaxDb; Q2XQY7; -.
DR   PRIDE; Q2XQY7; -.
DR   ProMEX; Q2XQY7; -.
DR   EnsemblPlants; PNW78175; PNW78175; CHLRE_10g467000v5.
DR   Gramene; PNW78175; PNW78175; CHLRE_10g467000v5.
DR   eggNOG; KOG0972; Eukaryota.
DR   HOGENOM; CLU_039132_0_0_1; -.
DR   InParanoid; Q2XQY7; -.
DR   OMA; VHAHDQD; -.
DR   OrthoDB; 839892at2759; -.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   InterPro; IPR019530; Intra-flagellar_transport_57.
DR   PANTHER; PTHR16011; PTHR16011; 1.
DR   Pfam; PF10498; IFT57; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Coiled coil.
FT   CHAIN           1..469
FT                   /note="Intraflagellar transport protein 57"
FT                   /id="PRO_0000328891"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          326..440
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   469 AA;  51309 MW;  4D3EC2BA785DA281 CRC64;
     MSSKRGGRSS LAKAPEEAVN GEAFAPEASP PPPGDDGDAG GEDGGAPAPP PPPATKGGPV
     AVGRSLEIQT TPDVCMEMLA DKLKLLNYEA DFCRKKKPYR KPLSRLYFAV PLANSSEQFF
     YFTSLATWLL GLAGVELPAP KEFDDPNLTC QNILGAVKKL GFAPPSYHPT KLTVGNGKEV
     VGVLDGLVDF VLERRHHKYS RPAYGNDGQP EEGVQLDDEA EAAAMEGADE LAMPAQNQAD
     DDEEEEGVYV DPGRGDAAGP GTGASAAMDA EKAVLVSKVD PTLWKIELER VAPKLRITIA
     ADSKDWRSHL DEAHQHKEVI SKAWPDSKTS LERLRADLNG TLEKLQTREK FLNEQFESLM
     QQYRAARTTF TDVQETYNRK TEAVADRNQE MHRIGETLEE VKAMMDEKGS NIADATPVAR
     IKTAIKQLNK ELHDMEVRIG VVSHTLLQLS LRNKRLLQAQ AALSDEEED