IFT57_DROME
ID IFT57_DROME Reviewed; 405 AA.
AC Q9VQS5; D6W4R8; S5MIX7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Intraflagellar transport protein 57 homolog;
GN Name=IFT57 {ECO:0000312|FlyBase:FBgn0031550};
GN Synonyms=Che-13 {ECO:0000312|FlyBase:FBgn0031550};
GN ORFNames=CG8853 {ECO:0000312|FlyBase:FBgn0031550};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the formation of cilia. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IFT57 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF51089.1; -; Genomic_DNA.
DR EMBL; BT124968; ADI33995.1; -; mRNA.
DR EMBL; BT150188; AGR51650.1; -; mRNA.
DR RefSeq; NP_608792.1; NM_134948.2.
DR AlphaFoldDB; Q9VQS5; -.
DR SMR; Q9VQS5; -.
DR STRING; 7227.FBpp0077218; -.
DR PaxDb; Q9VQS5; -.
DR PRIDE; Q9VQS5; -.
DR EnsemblMetazoa; FBtr0077529; FBpp0077218; FBgn0031550.
DR GeneID; 33579; -.
DR KEGG; dme:Dmel_CG8853; -.
DR UCSC; CG8853-RA; d. melanogaster.
DR CTD; 55081; -.
DR FlyBase; FBgn0031550; IFT57.
DR VEuPathDB; VectorBase:FBgn0031550; -.
DR eggNOG; KOG0972; Eukaryota.
DR GeneTree; ENSGT00390000006307; -.
DR HOGENOM; CLU_039132_0_0_1; -.
DR InParanoid; Q9VQS5; -.
DR OMA; VHAHDQD; -.
DR OrthoDB; 839892at2759; -.
DR PhylomeDB; Q9VQS5; -.
DR Reactome; R-DME-5610787; Hedgehog 'off' state.
DR Reactome; R-DME-5620924; Intraflagellar transport.
DR BioGRID-ORCS; 33579; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33579; -.
DR PRO; PR:Q9VQS5; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031550; Expressed in second segment of antenna (Drosophila) and 2 other tissues.
DR Genevisible; Q9VQS5; DM.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:FlyBase.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:FlyBase.
DR GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR InterPro; IPR019530; Intra-flagellar_transport_57.
DR PANTHER; PTHR16011; PTHR16011; 1.
DR Pfam; PF10498; IFT57; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..405
FT /note="Intraflagellar transport protein 57 homolog"
FT /id="PRO_0000328890"
FT COILED 252..380
FT /evidence="ECO:0000255"
FT CONFLICT 74
FT /note="K -> E (in Ref. 3; ADI33995)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="D -> N (in Ref. 3; ADI33995)"
FT /evidence="ECO:0000305"
FT CONFLICT 374
FT /note="N -> D (in Ref. 3; ADI33995)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="R -> L (in Ref. 3; ADI33995)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 405 AA; 47173 MW; 50D444195F995EFE CRC64;
MQQDDEQEKS QQLQNFQSDD LLEKLKLLNY EKHLLKEFKL KPLSRFYFVK ATNPGEQFYM
FTLICWWLCK KLGKDMERPQ EYDDPNTVAA NIIKLLGEID VPVDFQPNKL IRGAGPICLS
VLEVLSTQAC KVAQVGYQKL HIAQEEEFLG DYLEDNAEII LEKLEDEQNA AALSDDSDME
LEAHNFRQLN WLNRPQKKSN GDVNLDERNP ELDARMSDHQ EWHLELERVL PQLKVFVKAD
ARDWRTHISQ METLKTNILE NSDTAEAQLK KLHSEFTFDL EKIESREKHL NNELKPLIQQ
FKELSIELST IQYAQNQLQE DMEKQTAELN EVMMEQELKK EEMERRGQAM SDGSSVQQIR
KAIAKLKDDT AQLNLEVALL VHAHDQDIVV RQLQQNQTTD LANNP
