ID   IFT57_XENLA             Reviewed;         411 AA.
AC   A9ULY7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Intraflagellar transport protein 57 homolog;
GN   Name=ift57;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the formation of cilia. May also have pro-
CC       apoptotic function (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IFT57 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI57453.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC157452; AAI57453.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001108268.1; NM_001114796.1.
DR   AlphaFoldDB; A9ULY7; -.
DR   SMR; A9ULY7; -.
DR   BioGRID; 932507; 1.
DR   IntAct; A9ULY7; 1.
DR   MaxQB; A9ULY7; -.
DR   GeneID; 100137649; -.
DR   KEGG; xla:100137649; -.
DR   CTD; 100137649; -.
DR   OMA; VHAHDQD; -.
DR   OrthoDB; 839892at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 100137649; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR019530; Intra-flagellar_transport_57.
DR   PANTHER; PTHR16011; PTHR16011; 1.
DR   Pfam; PF10498; IFT57; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..411
FT                   /note="Intraflagellar transport protein 57 homolog"
FT                   /id="PRO_0000328887"
FT   REGION          317..408
FT                   /note="pDED"
FT   COILED          261..351
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  47274 MW;  6B4D5CAB653EF8A0 CRC64;
     MSEDSRRAED DDRGPGAAYQ AFLMMEDLLD KLKLLSYEDE VLRKQNMKPL SRHYFALPTN
     PGEQFYMFCT LSAWLINKAG NNFDQPQEYD DPNATISNIL SQLRSFGYSV DFPPSRLKAG
     YGEQVCYVLD CFAEEVLKHI RFSWKRPTYP TEEQDEETVV EDDAELTLNK IEDEIAEEDS
     DNDQEHFIDL KALSAQTQKL NAEESSKPEE ILESNTDAAE WILEVERVLP QLKVTIRTDN
     KDWRVHVDQM HQHRDGIDTS LKETKGYLDK LHNEIAKALE KVSSREKYIN NQLEQLVQEY
     RSAQAQLSEA KERYQQASGG VTERTRILAE ITEELEKVKQ EMEEKGSSMT DGAPLVKIKQ
     ALTKLKHEIV QMDIRTGVVE HTLLQSTLKE KSNMTRDMHA LNIPDSSIGA Y