ID   IFT57_XENTR             Reviewed;         411 AA.
AC   Q28HX4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Intraflagellar transport protein 57 homolog;
GN   Name=ift57; ORFNames=TEgg009c14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the formation of cilia. May also have pro-
CC       apoptotic function (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IFT57 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR760693; CAJ82224.1; -; mRNA.
DR   RefSeq; NP_001016561.1; NM_001016561.2.
DR   RefSeq; XP_012812437.1; XM_012956983.2.
DR   RefSeq; XP_012812438.1; XM_012956984.2.
DR   RefSeq; XP_017946753.1; XM_018091264.1.
DR   AlphaFoldDB; Q28HX4; -.
DR   SMR; Q28HX4; -.
DR   STRING; 8364.ENSXETP00000055345; -.
DR   PaxDb; Q28HX4; -.
DR   Ensembl; ENSXETT00000055345; ENSXETP00000055345; ENSXETG00000026185.
DR   GeneID; 549315; -.
DR   KEGG; xtr:549315; -.
DR   CTD; 55081; -.
DR   eggNOG; KOG0972; Eukaryota.
DR   HOGENOM; CLU_039132_0_0_1; -.
DR   InParanoid; Q28HX4; -.
DR   OMA; DWQMEVE; -.
DR   OrthoDB; 839892at2759; -.
DR   PhylomeDB; Q28HX4; -.
DR   TreeFam; TF106156; -.
DR   Reactome; R-XTR-5610787; Hedgehog 'off' state.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026185; Expressed in testis and 12 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR019530; Intra-flagellar_transport_57.
DR   PANTHER; PTHR16011; PTHR16011; 1.
DR   Pfam; PF10498; IFT57; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..411
FT                   /note="Intraflagellar transport protein 57 homolog"
FT                   /id="PRO_0000328888"
FT   REGION          317..408
FT                   /note="pDED"
FT   COILED          161..185
FT                   /evidence="ECO:0000255"
FT   COILED          261..351
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  47357 MW;  03A8E0CDD85DA217 CRC64;
     MSEDSRRVED DDRGPGAAYQ AFLMMEDLLD KLKLLSYEDE VLRKQNMKPL SRHYFALPTN
     PGEQFYMFCT LAAWLISKAG HHFDQPQEYD DPNATISNIL SELRSFGYSV DFPPSRLKAG
     YGEQVCYVLD CFAEEVLKHI HFSWKRPTYP TEEQDEENVI EDDAELTLNK IEDEIAEEDS
     DNDQEHFIDL NALSAQTQKL NTKESSKPEE ILESNTDAAE WILEVERVLP QLKVTIRTDN
     KDWRVHVDQM HQHRDGIDTS LKETKGYLDK LHNEVAKALE KVSSREKYIN NQLEQLVQEY
     RSVQAQLSEA KERYQQASGG VTERTRILAE ITEELEKVKQ EMEEKGSSMT DGAPLVKIKQ
     ALTKLKHEIV QMDIRTGVVE HTLLQSTLKE KSNMTRDMHA LNIPESSIGA Y