IFT80_HUMAN
ID IFT80_HUMAN Reviewed; 777 AA.
AC Q9P2H3; B4E0K1; C9J8I0; Q3MJC4; Q86YF4; Q9UIX1;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Intraflagellar transport protein 80 homolog;
DE AltName: Full=WD repeat-containing protein 56;
GN Name=IFT80; Synonyms=KIAA1374, WDR56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hypothalamus, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-777 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 577-777 (ISOFORM 1), AND VARIANT
RP SER-586.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP FUNCTION, AND VARIANTS SRTD2 GLN-105; LEU-549 DEL AND PRO-701.
RX PubMed=17468754; DOI=10.1038/ng2038;
RA Beales P.L., Bland E., Tobin J.L., Bacchelli C., Tuysuz B., Hill J.,
RA Rix S., Pearson C.G., Kai M., Hartley J., Johnson C., Irving M.,
RA Elcioglu N., Winey M., Tada M., Scambler P.J.;
RT "IFT80, which encodes a conserved intraflagellar transport protein, is
RT mutated in Jeune asphyxiating thoracic dystrophy.";
RL Nat. Genet. 39:727-729(2007).
RN [8]
RP CHARACTERIZATION OF ISOFORM IFT80-L, AND TISSUE SPECIFICITY.
RX PubMed=18601909; DOI=10.1016/j.bbrc.2008.06.085;
RA Huang W., Kane J.K., Li M.D.;
RT "Identification and characterization of a long isoform of human IFT80,
RT IFT80-L.";
RL Biochem. Biophys. Res. Commun. 373:653-658(2008).
CC -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B,
CC which is essential for the development and maintenance of motile and
CC sensory cilia. {ECO:0000269|PubMed:17468754}.
CC -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74,
CC IFT80, IFT81, and IFT88 (By similarity). Interacts with IFT88 (By
CC similarity). Interacts with IFT57 and TTC30B (By similarity).
CC {ECO:0000250|UniProtKB:Q8K057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250}. Note=Basal body and ciliary axoneme. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9P2H3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P2H3-2; Sequence=VSP_045456;
CC Name=IFT80-L;
CC IsoId=Q9P2H3-3; Sequence=VSP_057524;
CC -!- TISSUE SPECIFICITY: Isoform IFT80-L is widely expressed.
CC {ECO:0000269|PubMed:18601909}.
CC -!- DISEASE: Short-rib thoracic dysplasia 2 with or without polydactyly
CC (SRTD2) [MIM:611263]: A form of short-rib thoracic dysplasia, a group
CC of autosomal recessive ciliopathies that are characterized by a
CC constricted thoracic cage, short ribs, shortened tubular bones, and a
CC 'trident' appearance of the acetabular roof. Polydactyly is variably
CC present. Non-skeletal involvement can include cleft lip/palate as well
CC as anomalies of major organs such as the brain, eye, heart, kidneys,
CC liver, pancreas, intestines, and genitalia. Some forms of the disease
CC are lethal in the neonatal period due to respiratory insufficiency
CC secondary to a severely restricted thoracic cage, whereas others are
CC compatible with life. Disease spectrum encompasses Ellis-van Creveld
CC syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-
CC Saldino syndrome, and short rib-polydactyly syndrome.
CC {ECO:0000269|PubMed:17468754}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: [Isoform IFT80-L]: Based on a naturally occurring
CC readthrough transcript which produces a TRIM59-IFT80 fusion protein.
CC {ECO:0000305}.
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DR EMBL; AK303410; BAG64463.1; -; mRNA.
DR EMBL; AC024221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78643.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78644.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78645.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78646.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78648.1; -; Genomic_DNA.
DR EMBL; BC030774; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC042027; AAH42027.1; -; mRNA.
DR EMBL; BC101494; AAI01495.1; -; mRNA.
DR EMBL; BC113669; AAI13670.1; -; mRNA.
DR EMBL; AB037795; BAA92612.1; -; mRNA.
DR EMBL; AL133045; CAB61372.1; -; mRNA.
DR CCDS; CCDS3188.1; -. [Q9P2H3-1]
DR CCDS; CCDS54668.1; -. [Q9P2H3-2]
DR RefSeq; NP_001177170.1; NM_001190241.1. [Q9P2H3-2]
DR RefSeq; NP_001177171.1; NM_001190242.1. [Q9P2H3-2]
DR RefSeq; NP_065851.1; NM_020800.2. [Q9P2H3-1]
DR AlphaFoldDB; Q9P2H3; -.
DR SMR; Q9P2H3; -.
DR BioGRID; 121615; 32.
DR ComplexPortal; CPX-5022; IFT-B complex.
DR CORUM; Q9P2H3; -.
DR IntAct; Q9P2H3; 22.
DR MINT; Q9P2H3; -.
DR STRING; 9606.ENSP00000312778; -.
DR iPTMnet; Q9P2H3; -.
DR PhosphoSitePlus; Q9P2H3; -.
DR BioMuta; IFT80; -.
DR DMDM; 294862504; -.
DR EPD; Q9P2H3; -.
DR jPOST; Q9P2H3; -.
DR MassIVE; Q9P2H3; -.
DR MaxQB; Q9P2H3; -.
DR PaxDb; Q9P2H3; -.
DR PeptideAtlas; Q9P2H3; -.
DR PRIDE; Q9P2H3; -.
DR ProteomicsDB; 83816; -. [Q9P2H3-1]
DR ProteomicsDB; 9048; -.
DR Antibodypedia; 50241; 78 antibodies from 17 providers.
DR DNASU; 57560; -.
DR Ensembl; ENST00000326448.12; ENSP00000312778.7; ENSG00000068885.15. [Q9P2H3-1]
DR Ensembl; ENST00000483465.5; ENSP00000418196.1; ENSG00000068885.15. [Q9P2H3-2]
DR Ensembl; ENST00000496589.5; ENSP00000420646.1; ENSG00000068885.15. [Q9P2H3-2]
DR GeneID; 57560; -.
DR KEGG; hsa:57560; -.
DR MANE-Select; ENST00000326448.12; ENSP00000312778.7; NM_020800.3; NP_065851.1.
DR UCSC; uc003fdb.3; human. [Q9P2H3-1]
DR CTD; 57560; -.
DR DisGeNET; 57560; -.
DR GeneCards; IFT80; -.
DR HGNC; HGNC:29262; IFT80.
DR HPA; ENSG00000068885; Low tissue specificity.
DR MalaCards; IFT80; -.
DR MIM; 611177; gene.
DR MIM; 611263; phenotype.
DR neXtProt; NX_Q9P2H3; -.
DR OpenTargets; ENSG00000068885; -.
DR Orphanet; 474; Jeune syndrome.
DR Orphanet; 93268; Short rib-polydactyly syndrome, Beemer-Langer type.
DR Orphanet; 93271; Short rib-polydactyly syndrome, Verma-Naumoff type.
DR PharmGKB; PA142671664; -.
DR VEuPathDB; HostDB:ENSG00000068885; -.
DR eggNOG; KOG1524; Eukaryota.
DR GeneTree; ENSGT00440000033499; -.
DR HOGENOM; CLU_024638_1_0_1; -.
DR InParanoid; Q9P2H3; -.
DR OMA; CRTVEDE; -.
DR OrthoDB; 203079at2759; -.
DR PhylomeDB; Q9P2H3; -.
DR TreeFam; TF106117; -.
DR PathwayCommons; Q9P2H3; -.
DR Reactome; R-HSA-5620924; Intraflagellar transport.
DR SignaLink; Q9P2H3; -.
DR BioGRID-ORCS; 57560; 12 hits in 1076 CRISPR screens.
DR GeneWiki; IFT80; -.
DR GenomeRNAi; 57560; -.
DR Pharos; Q9P2H3; Tbio.
DR PRO; PR:Q9P2H3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9P2H3; protein.
DR Bgee; ENSG00000068885; Expressed in colonic epithelium and 184 other tissues.
DR ExpressionAtlas; Q9P2H3; baseline and differential.
DR Genevisible; Q9P2H3; HS.
DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097542; C:ciliary tip; TAS:Reactome.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030992; C:intraciliary transport particle B; IPI:ComplexPortal.
DR GO; GO:0061975; P:articular cartilage development; IEA:Ensembl.
DR GO; GO:0035630; P:bone mineralization involved in bone maturation; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0035720; P:intraciliary anterograde transport; IC:ComplexPortal.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:2000051; P:negative regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0033687; P:osteoblast proliferation; IEA:Ensembl.
DR GO; GO:0097500; P:receptor localization to non-motile cilium; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Ciliopathy; Cilium; Cytoplasm;
KW Cytoskeleton; Disease variant; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..777
FT /note="Intraflagellar transport protein 80 homolog"
FT /id="PRO_0000051042"
FT REPEAT 12..50
FT /note="WD 1"
FT REPEAT 104..143
FT /note="WD 2"
FT REPEAT 145..185
FT /note="WD 3"
FT REPEAT 186..225
FT /note="WD 4"
FT REPEAT 227..265
FT /note="WD 5"
FT REPEAT 267..306
FT /note="WD 6"
FT REPEAT 504..542
FT /note="WD 7"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..137
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045456"
FT VAR_SEQ 1..15
FT /note="MRLKISLLKEPKHQE -> MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNC
FT LENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIEKYQQEDHP
FT DIVTCPEHYRQPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYLKEKDTPQKLLEQ
FT LTDTHWTDLTHLIEKLKEQKSHSEKMIQGDKEAVLQYFKELNDTLEQKKKSFLTALCDV
FT GNLINQEYTPQIERMKEIREQQLELMALTISLQEESPLKFLEKVDDVRQHVQILKQRPL
FT PEVQPVEIYPRVSKILKEEWSRTEIGQIKNVLIPKMKISPKRMSCSWPG (in
FT isoform IFT80-L)"
FT /evidence="ECO:0000303|PubMed:18601909"
FT /id="VSP_057524"
FT VARIANT 105
FT /note="H -> Q (in SRTD2; dbSNP:rs137853115)"
FT /evidence="ECO:0000269|PubMed:17468754"
FT /id="VAR_035006"
FT VARIANT 549
FT /note="Missing (in SRTD2)"
FT /evidence="ECO:0000269|PubMed:17468754"
FT /id="VAR_035007"
FT VARIANT 586
FT /note="T -> S (in dbSNP:rs6778728)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035008"
FT VARIANT 701
FT /note="A -> P (in SRTD2; dbSNP:rs137853116)"
FT /evidence="ECO:0000269|PubMed:17468754"
FT /id="VAR_035009"
FT CONFLICT 14
FT /note="Q -> I (in Ref. 5; BAA92612)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="E -> D (in Ref. 4; AAH42027)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 88035 MW; 24C1BA59A5E5AE4D CRC64;
MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETTQI VKLPDDIYPI
DFHWFPKSLG VKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA
LVTVGEDGQI KIWSKTGMLR STLAQQGTPV YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK
VLQWKAHDGI ILKVDWNSVN DLILSAGEDC KYKVWDSYGR PLYNSQPHEH PITSVAWAPD
GELFAVGSFH TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
QHWEWKNFQV TLTKRRAMQV RNVLNDAVDL LEFRDRVIKA SLNYAHLVVS TSLQCYVFST
KNWNTPIIFD LKEGTVSLIL QAERHFLLVD GSSIYLYSYE GRFISSPKFP GMRTDILNAQ
TVSLSNDTIA IRDKADEKII FLFEASTGKP LGDGKFLSHK NEILEIALDQ KGLTNDRKIA
FIDKNRDLCI TSVKRFGKEE QIIKLGTMVH TLAWNDTCNI LCGLQDTRFI VWYYPNTVYV
DRDILPKTLY ERDASEFSKN PHIVSFVGNQ VTIRRADGSL VHISITPYPA ILHEYVSSSK
WEDAVRLCRF VKEQTMWACL AAMAVANRDM TTAEIAYAAI GEIDKVQYIN SIKNLPSKES
KMAHILLFSG NIQEAEIVLL QAGLVYQAIQ ININLYNWER ALELAVKYKT HVDTVLAYRQ
KFLETFGKQE TNKRYLHYAE GLQIDWEKIK AKIEMEITKE REQSSSSQSS KSIGLKP
