IFT80_RAT
ID IFT80_RAT Reviewed; 777 AA.
AC Q66HB3;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Intraflagellar transport protein 80 homolog;
DE AltName: Full=WD repeat-containing protein 56;
GN Name=Ift80; Synonyms=Wdr56;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B,
CC which is essential for the development and maintenance of motile and
CC sensory cilia. {ECO:0000250}.
CC -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74,
CC IFT80, IFT81, and IFT88 (By similarity). Interacts with IFT88 (By
CC similarity). Interacts with IFT57 and TTC30B (By similarity).
CC {ECO:0000250|UniProtKB:Q8K057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250}. Note=Basal body and ciliary axoneme. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC081931; AAH81931.1; -; mRNA.
DR EMBL; BC081937; AAH81937.1; -; mRNA.
DR RefSeq; NP_001013933.1; NM_001013911.1.
DR AlphaFoldDB; Q66HB3; -.
DR SMR; Q66HB3; -.
DR STRING; 10116.ENSRNOP00000013216; -.
DR PaxDb; Q66HB3; -.
DR Ensembl; ENSRNOT00000013216; ENSRNOP00000013216; ENSRNOG00000009808.
DR GeneID; 295106; -.
DR KEGG; rno:295106; -.
DR UCSC; RGD:1312006; rat.
DR CTD; 57560; -.
DR RGD; 1312006; Ift80.
DR eggNOG; KOG1524; Eukaryota.
DR GeneTree; ENSGT00440000033499; -.
DR InParanoid; Q66HB3; -.
DR OMA; WDAQGAN; -.
DR OrthoDB; 203079at2759; -.
DR PhylomeDB; Q66HB3; -.
DR TreeFam; TF106117; -.
DR Reactome; R-RNO-5620924; Intraflagellar transport.
DR PRO; PR:Q66HB3; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000009808; Expressed in testis and 18 other tissues.
DR Genevisible; Q66HB3; RN.
DR GO; GO:0097731; C:9+0 non-motile cilium; ISO:RGD.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR GO; GO:0061975; P:articular cartilage development; ISO:RGD.
DR GO; GO:0035630; P:bone mineralization involved in bone maturation; ISO:RGD.
DR GO; GO:0060349; P:bone morphogenesis; ISO:RGD.
DR GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD.
DR GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR GO; GO:0001958; P:endochondral ossification; ISO:RGD.
DR GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; ISO:RGD.
DR GO; GO:0003417; P:growth plate cartilage development; ISO:RGD.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:2000051; P:negative regulation of non-canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR GO; GO:0001649; P:osteoblast differentiation; ISO:RGD.
DR GO; GO:0033687; P:osteoblast proliferation; ISO:RGD.
DR GO; GO:0097500; P:receptor localization to non-motile cilium; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..777
FT /note="Intraflagellar transport protein 80 homolog"
FT /id="PRO_0000051044"
FT REPEAT 12..50
FT /note="WD 1"
FT REPEAT 104..143
FT /note="WD 2"
FT REPEAT 145..185
FT /note="WD 3"
FT REPEAT 186..225
FT /note="WD 4"
FT REPEAT 227..265
FT /note="WD 5"
FT REPEAT 267..306
FT /note="WD 6"
FT REPEAT 504..542
FT /note="WD 7"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 87780 MW; 4D1C68CDC8C600EF CRC64;
MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI VKLPDDIYPI
DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA
LVTVGEDGQV KIWSKTGMLR STLAQQGIPV YSVAWGPDSE KVLYTAGKQL IIKPLQPNAK
VLQWKAHDGI ILKVDWNSVN DLILSAGEDC KYKVWDSYGR VLYGSQPHEH PITSVAWAPD
GELFAVGSFH TLRLCDKTGW SYALEKPNTG SIFNIAWSID GTQIAGACGN GHVVFAHVVE
QRWEWKNFQV TLTKRRTMQV RNVLNDAVDL LEFRDRVIKA SLNHAHLVVS TSLQCYVFST
KNWNTPLIFD LKEGTVSLIL QAERHFLLVD GGGIYLHSYE GRFISSPKFP GMRTDILNAQ
TVSLSNDTIA IKDKADEKII FLFEASTGKP LGDGKLLSHK NEISEVALDQ KGLTNDRKIA
FIDKNRDLYI TSVKRFGKEE QIIKLGTMVH TLAWCDTCNI LCGLQDTRFT VWYYPNAVYV
DRDILPKTLY ERDASEYSKN PHIVSFVGNQ VTVRRADGSL VHISISPYPA ILHEYVSSSK
WEDAVRLCRF VKEQSLWACL AAMAVANRDM VTAEIAYAAV GEIDKVRYIN AMKDLPSRES
KMAHILMFSG NIQEAETILL QAGLVYQAIQ ININLYNWER ALELAVKYKT HVDTVLAYRQ
KFLETFGKQE TNKRYLQYAE GLQIDWEKIK AKIEMEITKE RDRSSSGQSS KNTGLKP
