ID   IFTNT_MYCBP             Reviewed;         176 AA.
AC   A0A0H3MAZ5;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Immunity factor for TNT homolog {ECO:0000250|UniProtKB:O05443};
DE            Short=IFT homolog {ECO:0000250|UniProtKB:O05443};
DE   AltName: Full=Tuberculosis necrotizing toxin homolog antitoxin {ECO:0000250|UniProtKB:O05443};
DE            Short=TNT homolog antitoxin {ECO:0000250|UniProtKB:O05443};
GN   OrderedLocusNames=BCG_3959c {ECO:0000312|EMBL:CAL73949.1};
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: Antitoxin for tuberculosis necrotizing toxin (TNT) homolog.
CC       Acts by binding directly to TNT, which inhibits NAD(+) glycohydrolase
CC       activity of TNT and protects M.bovis from self-poisoning.
CC       {ECO:0000250|UniProtKB:O05443}.
CC   -!- SUBUNIT: Interacts with the tuberculosis necrotizing toxin (TNT)
CC       homolog, the C-terminal domain of the outer membrane channel protein
CC       CpnT. {ECO:0000250|UniProtKB:O05443}.
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DR   EMBL; AM408590; CAL73949.1; -; Genomic_DNA.
DR   RefSeq; WP_003400086.1; NC_008769.1.
DR   AlphaFoldDB; A0A0H3MAZ5; -.
DR   SMR; A0A0H3MAZ5; -.
DR   KEGG; mbb:BCG_3959c; -.
DR   HOGENOM; CLU_1546538_0_0_11; -.
DR   OMA; YEGVERF; -.
DR   Proteomes; UP000001472; Chromosome.
DR   InterPro; IPR028953; Imm_IFT-like.
DR   Pfam; PF15598; Imm61; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..176
FT                   /note="Immunity factor for TNT homolog"
FT                   /id="PRO_0000437789"
SQ   SEQUENCE   176 AA;  19822 MW;  69925EC3709502EB CRC64;
     MTIGVDLSTD LQDWIRLSGM NMIQGSETND GRTILWNKGG EVRYFIDRLA GWYVITSSDR
     MSREGYEFAA ASMSVIEKYL YGYFGGSVRS ERELPAIRAP FQPEELMPEY SIGTMTFAGR
     QRDTLIDSSG TVVAITAADR LVELSHYLDV SVNVIKDSFL DSEGKPLFTL WKDYKG