IG2R_HUMAN
ID IG2R_HUMAN Reviewed; 113 AA.
AC P09565; Q96F00;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Putative insulin-like growth factor 2-associated protein;
DE AltName: Full=Cell growth-inhibiting gene 44 protein;
DE AltName: Full=Insulin-like growth factor II-associated protein {ECO:0000303|PubMed:3167054};
GN ORFNames=GIG44, PP9974;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kim J.W., Kim H.K., Shin S.M.;
RT "Identification of a human cell growth-inhibiting gene.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-84, AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=3167054; DOI=10.1016/0167-4781(88)90124-8;
RA de Pagter-Holthuizen P., van der Kammen R.A., Jansen M., van Schaik F.M.A.,
RA Sussenbach J.S.;
RT "Differential expression of the human insulin-like growth factor II gene.
RT Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-
RT II-associated protein.";
RL Biochim. Biophys. Acta 950:282-295(1988).
CC -!- INTERACTION:
CC P09565; P07339: CTSD; NbExp=3; IntAct=EBI-10196507, EBI-2115097;
CC P09565; P28799: GRN; NbExp=3; IntAct=EBI-10196507, EBI-747754;
CC P09565; P28799-2: GRN; NbExp=3; IntAct=EBI-10196507, EBI-25860013;
CC P09565; Q93062: RBPMS; NbExp=3; IntAct=EBI-10196507, EBI-740322;
CC P09565; Q13148: TARDBP; NbExp=6; IntAct=EBI-10196507, EBI-372899;
CC P09565; O76024: WFS1; NbExp=3; IntAct=EBI-10196507, EBI-720609;
CC -!- TISSUE SPECIFICITY: Expressed in fetal and adult liver.
CC {ECO:0000269|PubMed:3167054}.
CC -!- MISCELLANEOUS: Encoded within 3' untranslated region of IGF2 last exon
CC (exon 7). However, might be transcribed separately. Parallels IGF2 mRNA
CC in its abundance. {ECO:0000269|PubMed:3167054}.
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DR EMBL; AF318382; AAL55889.1; -; mRNA.
DR EMBL; AY971350; AAY40360.1; -; mRNA.
DR EMBL; BC011786; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC042127; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; X07868; CAA30718.1; -; Genomic_DNA.
DR PIR; S03384; S03384.
DR AlphaFoldDB; P09565; -.
DR IntAct; P09565; 6.
DR BioMuta; GIG44; -.
DR PRIDE; P09565; -.
DR neXtProt; NX_P09565; -.
DR PathwayCommons; P09565; -.
DR Pharos; P09565; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P09565; protein.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..113
FT /note="Putative insulin-like growth factor 2-associated
FT protein"
FT /id="PRO_0000084172"
FT CONFLICT 82..84
FT /note="GTC -> LPV (in Ref. 4; CAA30718)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 12087 MW; 348701816D3B6FC3 CRC64;
MTPGVVHASP PQSQRVPRQA PCEWAIRNIG QKPKEPNCHN CGTHIGLRSK TLRGTPNYLP
IRQDTHPPSV IFCLAGVGVP GGTCRPAPCV PRFAALPWAT NHPGPGCLSD LRA
