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IGA1B_STREE
ID   IGA1B_STREE             Reviewed;        1927 AA.
AC   Q54875;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Immunoglobulin A1 protease;
DE            Short=IgA1 protease;
DE            EC=3.4.24.13;
DE   AltName: Full=IgA-specific zinc metalloproteinase;
DE   Flags: Precursor;
GN   Name=iga;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=PK81 / Serotype 14;
RX   PubMed=8926055; DOI=10.1128/iai.64.10.3957-3966.1996;
RA   Poulsen K., Reinholdt J., Kilian M.;
RT   "Characterization of the Streptococcus pneumoniae immunoglobulin A1
RT   protease gene (iga) and its translation product.";
RL   Infect. Immun. 64:3957-3966(1996).
CC   -!- FUNCTION: Zinc metalloproteinase which cleaves human immunoglobulin A1
CC       (IgA1) in the hinge region, rendering it less efficient in coating the
CC       surface of colonizing or invading pneumococci. May be responsible for
CC       pneumococcal infection and is potentially involved in distinct stages
CC       of pneumococcal disease. {ECO:0000269|PubMed:8926055}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of Pro-|-Thr bond in the hinge region of the heavy
CC         chain of human IgA.; EC=3.4.24.13;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}. Membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
CC   -!- PTM: The Gram-positive cell-wall anchor motif LPXTG is located in the
CC       N-terminal part, in contrast to such motifs in other known
CC       streptococcal and staphylococcal proteins. The protease could be
CC       cleaved by the sortase and anchored in the membrane via the two
CC       potential N-terminal transmembrane domains, whereas the propeptide
CC       located prior to the LPXTG motif would remain attached to the cell wall
CC       peptidoglycan by an amide bond (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase M26 family. {ECO:0000305}.
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DR   EMBL; X94909; CAA64396.1; -; Genomic_DNA.
DR   PDB; 6OH1; NMR; -; A=313-393.
DR   PDBsum; 6OH1; -.
DR   AlphaFoldDB; Q54875; -.
DR   BMRB; Q54875; -.
DR   SMR; Q54875; -.
DR   MEROPS; M26.001; -.
DR   PRIDE; Q54875; -.
DR   BRENDA; 3.4.24.13; 1960.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR011098; G5_dom.
DR   InterPro; IPR011493; GLUG.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR011505; Peptidase_M26_C_dom.
DR   InterPro; IPR008006; Peptidase_M26_N_dom.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF07501; G5; 1.
DR   Pfam; PF07581; Glug; 1.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF07580; Peptidase_M26_C; 1.
DR   Pfam; PF05342; Peptidase_M26_N; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SMART; SM01208; G5; 1.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS51109; G5; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell wall; Hydrolase; Membrane; Metal-binding;
KW   Metalloprotease; Peptidoglycan-anchor; Protease; Repeat; Secreted; Signal;
KW   Transmembrane; Transmembrane helix; Virulence; Zinc.
FT   SIGNAL          1..42
FT                   /evidence="ECO:0000255"
FT   PROPEP          43..99
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000026835"
FT   CHAIN           100..1927
FT                   /note="Immunoglobulin A1 protease"
FT                   /id="PRO_0000026836"
FT   TRANSMEM        106..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..1927
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          314..393
FT                   /note="G5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00437"
FT   REPEAT          419..435
FT                   /note="1"
FT   REPEAT          436..452
FT                   /note="2"
FT   REPEAT          453..469
FT                   /note="3"
FT   REGION          235..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          419..469
FT                   /note="3 X 17 AA approximate tandem repeats"
FT   REGION          426..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           96..100
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        235..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..640
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1566
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         1565
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         1569
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         1589
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         99
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   STRAND          317..328
FT                   /evidence="ECO:0007829|PDB:6OH1"
FT   STRAND          332..337
FT                   /evidence="ECO:0007829|PDB:6OH1"
FT   STRAND          345..349
FT                   /evidence="ECO:0007829|PDB:6OH1"
FT   STRAND          354..367
FT                   /evidence="ECO:0007829|PDB:6OH1"
FT   STRAND          369..380
FT                   /evidence="ECO:0007829|PDB:6OH1"
FT   STRAND          385..390
FT                   /evidence="ECO:0007829|PDB:6OH1"
SQ   SEQUENCE   1927 AA;  215172 MW;  BAF74DB811301037 CRC64;
     MEKYFGEKQE RFSFRKLSVG LVSATISSLF FMSVLASSSV DAQETAGVHY KYVADSELSS
     EEKKQLVYDI PTYVENDDET YYLVYKLNSQ NQLAELPNTG SKNERQALVA GASLAALGIL
     IFAVSKKKVK NKTVLHLVLV AGIGNGVLVS VHALENHLLL NYNTDYELTS GEKLPLPKEI
     SGYTYIGYIK EGKTTSDFEV SNQEKSAATP TKQQKVDYNV TPNFVDHPST VQAIQEQTPV
     SSTKPTEVQV VEKPFSTELI NPRKEEKQSS DSQEQLAEHK NLETKKEEKI SPKEKTGVNT
     LNPQDEVLSG QLNKPELLYR EETIETKIDF QEEIQENPDL AEGTVRVKQE GKLGKKVEIV
     RIFSVNKEEV SREIVSTSTT APSPRIVEKG TKKTQVIKEQ PETGVEHKDV QSGAIVEPAI
     QPELPEAVVS DKGEPEVQPT LPEAVVTDKG EPAVQPELPE AVVSDKGEPE QVAPLPEYKG
     NIEQVKPETP VEKTKEQGPE KTEEVPVKPT EETPVNPNEG TTEGTSIQGA ENPVQPAEDT
     QTNSGKIANE NTGEVSNKPS DSKPPVEESN QPEKNGTATK PENSGNTTSE NGQTEPEPSN
     GNSTEDVSTK SNTSNSNGNE EIKQENELDP DKKVEDPEKT LELRNVSDLE LYSLSNGTYK
     QHISLEQVPS NPNSYFVKVK SSSFKDVYLP VASISEGRKN DKILYKITAK VEKLQQEIES
     RYKDNFTFYL AKKGTEETTN FTSFSNLVKA INQNLSGTYH LGASLNANEV ELSTDDKSYI
     KGTFTGQLIG EKDGKHYAIY NLKKPLFENL SGATVEKLSL KNVAISGKND IGSLANEATN
     GTKIKQVHVD GVLAGERGVG GLLAKADQSS IAESSFKGRI VNTYETTDSY NIGGLVGHLT
     GKNASIAKSK ATVTISSNTN RSDQTVGGLA GLVDRDAQIQ DSYAEGDINN VKHFGRVAGV
     AGNLWDRTSG DVRHAGSLTN VLSDVNVTNG NAITGYHYTG MKVANTFSSK ANRVFNVTLE
     KNEVVSKESF EERGTMLDAS QIASKKAEIN LITPPIVEPL STSGKKDSDF SKIAHYQANR
     ALVYKNIEKL LPFYNKATIV KYGNLVKENS ILYQKELLSA VMMKDDQVIT DIISNKQTAN
     KLLLHYKDHS SEKFDLRYQA DFANLAEYSI GDSGLLYTPN QFLYHQDSII NQVLPELNRV
     NYQSDAVRNT LGISPEVKLT ELYLEEQFTK TKEHLAENLK KLLSSDAGLV TDNEVMTGYI
     IDKIKRNKEA LLLGMSYLER WYNFSYGQVN VKDLVMYHPD FFGKGNTSPL DTLIELGKSG
     FNNLLAKNNV DTYAISLASH HGTTDLFSTL ENYRKVFLPD KTNNDWFKSQ TKAYIVEEKS
     NIEEVKTKQG LVGTKYSIGV YDRITSATWK YRNMVLPLLT LPERSVFVIS TISSLGFGAY
     DRYRNKEHQA NGDLNSFVEK SAHETAERQR DHYDYWYRIL DEKGREKLYR NILLYDAYKF
     GTNHTEGKAT EVADFDSPNP AMKHFFGPVG NKVGHNGHGA YATGDAVYYM GYRMLDKDGA
     ITYTHEMTHN SDQDIYLGGY GRRSGLGPEF FAKGLLQAPD QPSDATITIN SILKHSKSDS
     KEGERLQVLD PTTRFKDATD LQKYVHNMFD VVYMLEYLEG KSIVKKLNVY QKIEALRKIE
     NQYLTDPADG NDVYATNVVK NLTEDEAKKL TSFDSLIDNN ILSAREYKAG TYERNGYFTI
     KLFAPIFSAL SGEKGTPGDL MGRRIAFELL AAKGFKDGMV PYISNQYEED AKQQGQTINL
     YGKERGLVTD ELVLKKVFDG KYKTWAEFKT AMYQERVDQF GNLKQVTFKD PTKPWPRYGT
     KTINNVDELQ KLMDEAVLQD AKERNYYYWN NYNPETDSAV HKLKRAIFKA YLDQTNDFRR
     SIFENKK
 
 
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