ID   IGAA_ECO57              Reviewed;         711 AA.
AC   P58720;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Putative membrane protein IgaA homolog;
GN   Name=yrfF; OrderedLocusNames=Z4752, ECs4240;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IgaA family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58498.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37663.1; -; Genomic_DNA.
DR   PIR; F86004; F86004.
DR   PIR; H91158; H91158.
DR   RefSeq; NP_312267.1; NC_002695.1.
DR   RefSeq; WP_000104518.1; NZ_SEKU01000003.1.
DR   AlphaFoldDB; P58720; -.
DR   BMRB; P58720; -.
DR   SMR; P58720; -.
DR   STRING; 155864.EDL933_4597; -.
DR   EnsemblBacteria; AAG58498; AAG58498; Z4752.
DR   EnsemblBacteria; BAB37663; BAB37663; ECs_4240.
DR   GeneID; 915906; -.
DR   KEGG; ece:Z4752; -.
DR   KEGG; ecs:ECs_4240; -.
DR   PATRIC; fig|386585.9.peg.4427; -.
DR   eggNOG; ENOG502Z8KK; Bacteria.
DR   HOGENOM; CLU_014723_0_0_6; -.
DR   OMA; DLIYPPH; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010771; IgaA.
DR   Pfam; PF07095; IgaA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..711
FT                   /note="Putative membrane protein IgaA homolog"
FT                   /id="PRO_0000215015"
FT   TOPO_DOM        1
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..655
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        656..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        677..711
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   711 AA;  79473 MW;  38789B79E29E7DE1 CRC64;
     MSTIVIFLAA LLACSLLAGW LIKVRSRRRQ LPWTNAFADA QTRKLTPEER SAVENYLESL
     TQVLQVPGPT GASAAPISLA LNAESNNVMM LTHAITRYGI STDDPNKWRY YLDSVEVHLP
     PFWEQYINDE NTVELIHTDS LPLVISLNGH TLQEYMQETR GYALQPVPST QASIRGEESE
     QIELLNIRKE THEEYALSRP RGLREALLIV ASFLMFFFCL ITPDVFVPWL AGGALLLLGA
     GLWGLFAPPA KSSLREIHCL RGTPRRWGLF GENDQEQINN ISLGIIDLVY PAHWQPYIAQ
     DLGQQTDIDI YLDRHLVRQG RYLSLHDEVK NFPLQHWLRS TIIAAGSLLV LFMLLFWIPL
     DMPLKFTLSW MKGAQTIEAT SVKQLADAGV RVGDTLRISG TGMCNIRTSG TWSAKTNSPF
     LPFDCSQIIW NDARSLPLPE SELVNKATAL TEAVNRQLHP KPEDESRVSA SLRSAIQKSG
     MVLLDDFGDI VLKTADLCSA KDDCVRLKNA LVNLGNSKDW DALVKRANAG KLDGVNVLLR
     PVSAESLDNL VATSTAPFIT HETARAAQSL NSPAPGGFLI VSDEGSDFVD QPWPSASLYD
     YPPQEQWNAF QKLAQMLMHT PFNAEGIVTK IFTDANGTQH IGLHPIPDRS GLWRYLSTTL
     LLLTMLGSAI YNGVQAWRRY QRHRTRMMKI QAYYESCLNP QLITPSESLI E