IGAA_ECOLI
ID IGAA_ECOLI Reviewed; 711 AA.
AC P45800; Q2M763;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Putative membrane protein IgaA homolog;
GN Name=yrfF; OrderedLocusNames=b3398, JW3361;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the IgaA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U18997; AAA58195.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76423.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77893.1; -; Genomic_DNA.
DR PIR; A65135; A65135.
DR RefSeq; NP_417857.1; NC_000913.3.
DR RefSeq; WP_000104533.1; NZ_SSZK01000008.1.
DR PDB; 4UZM; NMR; -; A=36-154.
DR PDBsum; 4UZM; -.
DR AlphaFoldDB; P45800; -.
DR BMRB; P45800; -.
DR SMR; P45800; -.
DR DIP; DIP-12922N; -.
DR IntAct; P45800; 3.
DR STRING; 511145.b3398; -.
DR jPOST; P45800; -.
DR PaxDb; P45800; -.
DR PRIDE; P45800; -.
DR EnsemblBacteria; AAC76423; AAC76423; b3398.
DR EnsemblBacteria; BAE77893; BAE77893; BAE77893.
DR GeneID; 947905; -.
DR KEGG; ecj:JW3361; -.
DR KEGG; eco:b3398; -.
DR PATRIC; fig|1411691.4.peg.3332; -.
DR EchoBASE; EB2763; -.
DR eggNOG; ENOG502Z8KK; Bacteria.
DR HOGENOM; CLU_014723_0_0_6; -.
DR OMA; DLIYPPH; -.
DR PhylomeDB; P45800; -.
DR BioCyc; EcoCyc:G7741-MON; -.
DR PRO; PR:P45800; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0036460; P:cellular response to cell envelope stress; IDA:EcoCyc.
DR GO; GO:0070297; P:regulation of phosphorelay signal transduction system; IDA:EcoCyc.
DR InterPro; IPR010771; IgaA.
DR Pfam; PF07095; IgaA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..711
FT /note="Putative membrane protein IgaA homolog"
FT /id="PRO_0000215014"
FT TOPO_DOM 1
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..655
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 656..676
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 677..711
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:4UZM"
FT HELIX 47..62
FT /evidence="ECO:0007829|PDB:4UZM"
FT HELIX 83..86
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 87..93
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 95..98
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 103..107
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 109..112
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 115..118
FT /evidence="ECO:0007829|PDB:4UZM"
FT TURN 124..126
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 129..137
FT /evidence="ECO:0007829|PDB:4UZM"
FT STRAND 139..147
FT /evidence="ECO:0007829|PDB:4UZM"
SQ SEQUENCE 711 AA; 79490 MW; C9222D0F3403BA03 CRC64;
MSTIVIFLAA LLACSLLAGW LIKVRSRRRQ LPWTNAFADA QTRKLTPEER SAVENYLESL
TQVLQVPGPT GASAAPISLA LNAESNNVMM LTHAITRYGI STDDPNKWRY YLDSVEVHLP
PFWEQYINDE NTVELIHTDS LPLVISLNGH TLQEYMQETR SYALQPVPST QASIRGEESE
QIELLNIRKE THEEYALSRP RGLREALLIV ASFLMFFFCL ITPDVFVPWL AGGALLLLGA
GLWGLFAPPA KSSLREIHCL RGTPRRWGLF GENDQEQINN ISLGIIDLVY PAHWQPYIAQ
DLGQQTDIDI YLDRHVVRQG RYLSLHDEVK NFPLQHWLRS TIIAAGSLLV LFMLLFWIPL
DMPLKFTLSW MKGAQTIEAT SVKQLADAGV RVGDTLRISG TGMCNIRTSG TWSAKTNSPF
LPFDCSQIIW NDARSLPLPE SELVNKATAL TEAVNRQLHP KPEDESRVSA SLRSAIQKSG
MVLLDDFGDI VLKTADLCSA KDDCVRLKNA LVNLGNSKDW DALVKRANAG KLDGVNVLLR
PVSAESLDNL VATSTAPFIT HETARAAQSL NSPAPGGFLI VSDEGSDFVD QPWPSASLYD
YPPQEQWNAF QKLAQMLMHT PFNAEGIVTK IFTDANGTQH IGLHPIPDRS GLWRYLSTTL
LLLTMLGSAI YNGVQAWRRY QRHRTRMMEI QAYYESCLNP QLITPSESLI E
