ID   IGAA_SALTI              Reviewed;         710 AA.
AC   P58721;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Putative membrane protein IgaA homolog;
GN   Name=yrfF; OrderedLocusNames=STY4301, t4011;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IgaA family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD08119.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71481.1; -; Genomic_DNA.
DR   RefSeq; NP_458409.1; NC_003198.1.
DR   RefSeq; WP_000104086.1; NZ_WSUR01000001.1.
DR   AlphaFoldDB; P58721; -.
DR   SMR; P58721; -.
DR   STRING; 220341.16505098; -.
DR   EnsemblBacteria; AAO71481; AAO71481; t4011.
DR   KEGG; stt:t4011; -.
DR   KEGG; sty:STY4301; -.
DR   PATRIC; fig|220341.7.peg.4396; -.
DR   eggNOG; ENOG502Z8KK; Bacteria.
DR   HOGENOM; CLU_014723_0_0_6; -.
DR   OMA; DLIYPPH; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010771; IgaA.
DR   Pfam; PF07095; IgaA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..710
FT                   /note="Putative membrane protein IgaA homolog"
FT                   /id="PRO_0000215016"
FT   TOPO_DOM        1
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..656
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        678..710
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   710 AA;  79366 MW;  8C9B186731FA6266 CRC64;
     MSTILIFIAA LLACSLLAIW RFRVKSRRGS LPWFSAFQDA QTRKLLPEER SAVENYLDNL
     SQIQQVPGPT GASAAPISLT LNAESNSVVI LTHSITRYGI TTDDPNKWRY YLDSVEVHLP
     PFWEQYINDE NNVELILTDT LPLVISLNGH TLQEYMQESR GYALQNTAST QASIRGEESE
     QIELLNIRQE THEEYALSRP AGLREALLIV ASFLLFFFCL ITPDVFVPWM IGGAILLLAA
     GLWGLFAPPS KSALREIHCL RGTPRRWGLF GENNQEQINN ISLGIIDLIY PAHWQPYITQ
     DLGQQTDIDI YLDRHVARQG RFLSLHDEVK NFPLQHWLRS TVIAIGSLLV LFMLLFWIPL
     DMPIKFTLSW MKGAQTIEAT TVKQLEKAGV RVGDTLHLSG KGMCNIHSGA TWSGQSNSPF
     MPFDCSQIIW NDAPALPLPE SDLVNKAMAL SQAVNRQLHP KPEDDSRVSA SLRSAIQKSG
     MVLLDDFGDI VLKTADLCAA EDECVRLKNA LVNLGNSKDW NALVKRANAG KLDGVNVLLR
     PVSAESLENL VTTSTAPFIS RETARAAQSL NSPAPGGFLI ASDEGSELVD QAWPSTPLYD
     YPAQEQWSAF QRLAQTLMQT PFSAEGIVTS VYTDANGTQH ISLHRIPDKS GWWRYLGTTL
     LMLAMIVSAV YNGIQAFRRY QRHRTRMADI QEYYESCLNP RLTVSPENLI