ID   IGAA_SALTS              Reviewed;         710 AA.
AC   E1WIS2; Q9ACP0;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Intracellular growth attenuator protein IgaA;
GN   Name=igaA; OrderedLocusNames=SL1344_3462;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND MUTAGENESIS OF ARG-188.
RC   STRAIN=SL1344;
RX   PubMed=11553591; DOI=10.1128/iai.69.10.6463-6474.2001;
RA   Cano D.A., Martinez-Moya M., Pucciarelli M.G., Groisman E.A., Casadesus J.,
RA   Garcia-del Portillo F.;
RT   "Salmonella enterica serovar Typhimurium response involved in attenuation
RT   of pathogen intracellular proliferation.";
RL   Infect. Immun. 69:6463-6474(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC   -!- FUNCTION: Involved in negative control of bacterial proliferation
CC       within fibroblasts. {ECO:0000269|PubMed:11553591}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IgaA family. {ECO:0000305}.
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DR   EMBL; AJ301649; CAC37392.1; -; Genomic_DNA.
DR   EMBL; FQ312003; CBW19557.1; -; Genomic_DNA.
DR   RefSeq; WP_000104094.1; NZ_QASL01000006.1.
DR   AlphaFoldDB; E1WIS2; -.
DR   SMR; E1WIS2; -.
DR   EnsemblBacteria; CBW19557; CBW19557; SL1344_3462.
DR   KEGG; sey:SL1344_3462; -.
DR   PATRIC; fig|216597.6.peg.3854; -.
DR   HOGENOM; CLU_014723_0_0_6; -.
DR   OMA; DLIYPPH; -.
DR   BioCyc; SENT216597:SL1344_RS18035-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR010771; IgaA.
DR   Pfam; PF07095; IgaA; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Growth regulation; Membrane;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..710
FT                   /note="Intracellular growth attenuator protein IgaA"
FT                   /id="PRO_0000405424"
FT   TOPO_DOM        1
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..656
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        678..710
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MUTAGEN         188
FT                   /note="R->H: Increased ability to proliferate within
FT                   fibroblasts."
FT                   /evidence="ECO:0000269|PubMed:11553591"
SQ   SEQUENCE   710 AA;  79362 MW;  D4A07C386EC560F9 CRC64;
     MSTILIFIAA LLACSLLAIW RFRVKSRRGS LPWISAFQDA QTRKLLPEER SAVENYLDNL
     SQIQQVPGPT GASAAPISLT LNAESNSVVI LTHSITRYGI TTDDPNKWRY YLDSVEVHLP
     PFWEQYINDE NNVELILTDT LPLVISLNGH TLQEYMQESR GYALQNTAST QASIRGEESE
     QIELLNIRQE THEEYALSRP AGLREALLIV ASFLLFFFCL ITPDVFVPWM IGGAILLLAA
     GLWGLFAPPS KSALREIHCL RGTPRRWGLF GENNQEQINN ISLGIIDLIY PAHWQPYITQ
     DLGQQTDIDI YLDRHVARQG RFLSLHDEVK NFPLQHWLRS TVIAIGSLLV LFMLLFWIPL
     DMPIKFTLSW MKGAQTIEAT TVKQLEKAGV RVGDTLHLSG KGMCNIHSGA TWSGQSNSPF
     MPFDCSQIIW NDAPALPLPE SDLVNKAMAL SQAVNRQLHP KPEDDSRVSA SLRSAIQKSG
     MVLLDDFGDI VLKTADLCAA EDECVRLKNA LVNLGNSKDW NALVKRANAG KLDGVNVLLR
     PVSAESLENL VTTSTAPFIS RETARAAQSL NSPAPGGFLI ASDEGSELVD QTWPSTPLYD
     YPAQEQWSAF QRLAQTLMQT PFSAEGIVTS VYTDANGTQH ISLHRIPDKS GWWRYLGTTL
     LMLAMIVSAV YNGIQAFRRY QRHRTRMADI QEYYESCLNP RLTVSPENLI