ID   IGAA_SALTY              Reviewed;         710 AA.
AC   P0CL13; Q9ACP0;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Intracellular growth attenuator protein IgaA;
GN   Name=igaA; OrderedLocusNames=STM3495;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in negative control of bacterial proliferation
CC       within fibroblasts. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IgaA family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL22357.1; -; Genomic_DNA.
DR   RefSeq; NP_462398.1; NC_003197.2.
DR   RefSeq; WP_000104094.1; NC_003197.2.
DR   AlphaFoldDB; P0CL13; -.
DR   SMR; P0CL13; -.
DR   STRING; 99287.STM3495; -.
DR   PaxDb; P0CL13; -.
DR   EnsemblBacteria; AAL22357; AAL22357; STM3495.
DR   GeneID; 1255018; -.
DR   KEGG; stm:STM3495; -.
DR   PATRIC; fig|99287.12.peg.3694; -.
DR   HOGENOM; CLU_014723_0_0_6; -.
DR   OMA; DLIYPPH; -.
DR   PhylomeDB; P0CL13; -.
DR   BioCyc; SENT99287:STM3495-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR010771; IgaA.
DR   Pfam; PF07095; IgaA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Growth regulation; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..710
FT                   /note="Intracellular growth attenuator protein IgaA"
FT                   /id="PRO_0000215017"
FT   TOPO_DOM        1
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..656
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        678..710
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   710 AA;  79362 MW;  D4A07C386EC560F9 CRC64;
     MSTILIFIAA LLACSLLAIW RFRVKSRRGS LPWISAFQDA QTRKLLPEER SAVENYLDNL
     SQIQQVPGPT GASAAPISLT LNAESNSVVI LTHSITRYGI TTDDPNKWRY YLDSVEVHLP
     PFWEQYINDE NNVELILTDT LPLVISLNGH TLQEYMQESR GYALQNTAST QASIRGEESE
     QIELLNIRQE THEEYALSRP AGLREALLIV ASFLLFFFCL ITPDVFVPWM IGGAILLLAA
     GLWGLFAPPS KSALREIHCL RGTPRRWGLF GENNQEQINN ISLGIIDLIY PAHWQPYITQ
     DLGQQTDIDI YLDRHVARQG RFLSLHDEVK NFPLQHWLRS TVIAIGSLLV LFMLLFWIPL
     DMPIKFTLSW MKGAQTIEAT TVKQLEKAGV RVGDTLHLSG KGMCNIHSGA TWSGQSNSPF
     MPFDCSQIIW NDAPALPLPE SDLVNKAMAL SQAVNRQLHP KPEDDSRVSA SLRSAIQKSG
     MVLLDDFGDI VLKTADLCAA EDECVRLKNA LVNLGNSKDW NALVKRANAG KLDGVNVLLR
     PVSAESLENL VTTSTAPFIS RETARAAQSL NSPAPGGFLI ASDEGSELVD QTWPSTPLYD
     YPAQEQWSAF QRLAQTLMQT PFSAEGIVTS VYTDANGTQH ISLHRIPDKS GWWRYLGTTL
     LMLAMIVSAV YNGIQAFRRY QRHRTRMADI QEYYESCLNP RLTVSPENLI