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IGDC3_HUMAN
ID   IGDC3_HUMAN             Reviewed;         814 AA.
AC   Q8IVU1; O95215;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Immunoglobulin superfamily DCC subclass member 3;
DE   AltName: Full=Putative neuronal cell adhesion molecule;
DE   Flags: Precursor;
GN   Name=IGDCC3; Synonyms=PUNC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-751.
RC   TISSUE=Eye, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 507-814, AND VARIANT LEU-751.
RC   TISSUE=Placenta;
RX   PubMed=9922388; DOI=10.1007/s003359900953;
RA   Salbaum J.M.;
RT   "Genomic structure and chromosomal localization of the mouse gene Punc.";
RL   Mamm. Genome 10:107-111(1999).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC       {ECO:0000305}.
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DR   EMBL; AC105129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC042054; AAH42054.1; -; mRNA.
DR   EMBL; BC067107; AAH67107.1; -; mRNA.
DR   EMBL; AF063936; AAD13399.1; -; mRNA.
DR   CCDS; CCDS10205.1; -.
DR   RefSeq; NP_004875.2; NM_004884.3.
DR   AlphaFoldDB; Q8IVU1; -.
DR   SMR; Q8IVU1; -.
DR   BioGRID; 114918; 2.
DR   STRING; 9606.ENSP00000332773; -.
DR   GlyGen; Q8IVU1; 7 sites.
DR   iPTMnet; Q8IVU1; -.
DR   PhosphoSitePlus; Q8IVU1; -.
DR   BioMuta; IGDCC3; -.
DR   DMDM; 296434537; -.
DR   EPD; Q8IVU1; -.
DR   MassIVE; Q8IVU1; -.
DR   PaxDb; Q8IVU1; -.
DR   PeptideAtlas; Q8IVU1; -.
DR   PRIDE; Q8IVU1; -.
DR   ProteomicsDB; 70769; -.
DR   Antibodypedia; 2652; 43 antibodies from 12 providers.
DR   DNASU; 9543; -.
DR   Ensembl; ENST00000327987.9; ENSP00000332773.4; ENSG00000174498.14.
DR   GeneID; 9543; -.
DR   KEGG; hsa:9543; -.
DR   MANE-Select; ENST00000327987.9; ENSP00000332773.4; NM_004884.4; NP_004875.2.
DR   UCSC; uc002aos.2; human.
DR   CTD; 9543; -.
DR   DisGeNET; 9543; -.
DR   GeneCards; IGDCC3; -.
DR   HGNC; HGNC:9700; IGDCC3.
DR   HPA; ENSG00000174498; Tissue enhanced (brain, parathyroid gland, placenta).
DR   MIM; 604184; gene.
DR   neXtProt; NX_Q8IVU1; -.
DR   OpenTargets; ENSG00000174498; -.
DR   PharmGKB; PA164720881; -.
DR   VEuPathDB; HostDB:ENSG00000174498; -.
DR   eggNOG; KOG4221; Eukaryota.
DR   eggNOG; KOG4222; Eukaryota.
DR   GeneTree; ENSGT00940000156969; -.
DR   HOGENOM; CLU_018612_2_0_1; -.
DR   InParanoid; Q8IVU1; -.
DR   OMA; CGLMEGK; -.
DR   OrthoDB; 1010015at2759; -.
DR   PhylomeDB; Q8IVU1; -.
DR   TreeFam; TF321506; -.
DR   PathwayCommons; Q8IVU1; -.
DR   SignaLink; Q8IVU1; -.
DR   BioGRID-ORCS; 9543; 13 hits in 1072 CRISPR screens.
DR   ChiTaRS; IGDCC3; human.
DR   GenomeRNAi; 9543; -.
DR   Pharos; Q8IVU1; Tdark.
DR   PRO; PR:Q8IVU1; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q8IVU1; protein.
DR   Bgee; ENSG00000174498; Expressed in oocyte and 125 other tissues.
DR   ExpressionAtlas; Q8IVU1; baseline and differential.
DR   Genevisible; Q8IVU1; HS.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; -; 6.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 2.
DR   PROSITE; PS50835; IG_LIKE; 4.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..814
FT                   /note="Immunoglobulin superfamily DCC subclass member 3"
FT                   /id="PRO_0000014920"
FT   TRANSMEM        641..661
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..139
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          140..220
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          238..321
FT                   /note="Ig-like C2-type 3"
FT   DOMAIN          329..416
FT                   /note="Ig-like C2-type 4"
FT   DOMAIN          426..520
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          523..618
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          722..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          762..814
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        246
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        381
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        382
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        580
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        604
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        634
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        63..117
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        160..209
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        259..307
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        351..400
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         751
FT                   /note="V -> L (in dbSNP:rs12907128)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:9922388"
FT                   /id="VAR_060356"
FT   CONFLICT        598
FT                   /note="N -> S (in Ref. 3; AAD13399)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        650
FT                   /note="T -> A (in Ref. 3; AAD13399)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        654
FT                   /note="F -> L (in Ref. 3; AAD13399)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        729
FT                   /note="Q -> R (in Ref. 3; AAD13399)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   814 AA;  86724 MW;  7081B88569F77C68 CRC64;
     MAVQRAASPR RPPAPLWPRL LLPLLLLLLP APSEGLGHSA ELAFAVEPSD DVAVPGQPIV
     LDCRVEGTPP VRITWRKNGV ELPESTHSTL LANGSLMIRH FRLEPGGSPS DEGDYECVAQ
     NRFGLVVSRK ARIQAATMSD FHVHPQATVG EEGGVARFQC QIHGLPKPLI TWEKNRVPID
     TDNERYTLLP KGVLQITGLR AEDGGIFHCV ASNIASIRIS HGARLTVSGS GSGAYKEPAI
     LVGPENLTLT VHQTAVLECV ATGNPRPIVS WSRLDGRPIG VEGIQVLGTG NLIISDVTVQ
     HSGVYVCAAN RPGTRVRRTA QGRLVVQAPA EFVQHPQSIS RPAGTTAMFT CQAQGEPPPH
     VTWLKNGQVL GPGGHVRLKN NNSTLTISGI GPEDEAIYQC VAENSAGSSQ ASARLTVLWA
     EGLPGPPRNV RAVSVSSTEV RVSWSEPLAN TKEIIGYVLH IRKAADPPEL EYQEAVSKST
     FQHLVSDLEP STAYSFYIKA YTPRGASSAS VPTLASTLGE APAPPPLSVR VLGSSSLQLL
     WEPWPRLAQH EGGFKLFYRP ASKTSFTGPI LLPGTVSSYN LSQLDPTAVY EVKLLAYNQH
     GDGNATVRFV SLRGASERTA LSPPCDCRKE EAANQTSTTG IVIGIHIGVT CIIFCVLFLL
     FGQRGRVLLC KDVENQLSPP QGPRSQRDPG ILALNGARRG QRGQLGRDEK RVDMKELEQL
     FPPASAAGQP DPRPTQDPAA PAPCEETQLS VLPLQGCGLM EGKTTEAKTT EATAPCAGLA
     AAPPPPDGGP GLLSEGQASR PAAARVTQPA HSEQ
 
 
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