IGDC3_MOUSE
ID IGDC3_MOUSE Reviewed; 813 AA.
AC Q8BQC3; O70246; Q792T2; Q9Z2S6;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Immunoglobulin superfamily DCC subclass member 3;
DE AltName: Full=Putative neuronal cell adhesion molecule;
DE Flags: Precursor;
GN Name=Igdcc3; Synonyms=Punc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 599-735 (ISOFORM 2), DEVELOPMENTAL STAGE, AND
RP TISSUE SPECIFICITY.
RC STRAIN=Swiss Webster;
RX PubMed=9507132; DOI=10.1016/s0925-4773(98)00005-7;
RA Salbaum J.M.;
RT "Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed
RT predominantly in the developing nervous system.";
RL Mech. Dev. 71:201-204(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 599-735 (ISOFORMS 1 AND 2), AND
RP TISSUE SPECIFICITY.
RC STRAIN=FVB/NJ;
RX PubMed=9922388; DOI=10.1007/s003359900953;
RA Salbaum J.M.;
RT "Genomic structure and chromosomal localization of the mouse gene Punc.";
RL Mamm. Genome 10:107-111(1999).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BQC3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BQC3-2; Sequence=VSP_012321;
CC -!- TISSUE SPECIFICITY: Detected in cerebellum, kidney, heart, lung,
CC skeletal muscle and spleen. {ECO:0000269|PubMed:9507132,
CC ECO:0000269|PubMed:9922388}.
CC -!- DEVELOPMENTAL STAGE: Strongly expressed in embryos from 9.5 dpc to 10.5
CC dpc. Expression is much lower at 11.5 dpc and virtually extinct at 15.5
CC dpc. Detected in neural tube and lateral mesoderm at 9.5 dpc. At 10.5
CC dpc detected in fore and hind limb buds and lateral plate mesoderm,
CC throughout the neural tube, in mesencephalon and dorsal diencephalon.
CC {ECO:0000269|PubMed:9507132}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000305}.
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DR EMBL; AK051027; BAC34502.1; -; mRNA.
DR EMBL; BC053057; AAH53057.1; -; mRNA.
DR EMBL; AF026465; AAD12133.1; -; mRNA.
DR EMBL; AF026466; AAD12123.1; -; Genomic_DNA.
DR EMBL; AF026466; AAD12124.1; -; Genomic_DNA.
DR CCDS; CCDS52835.1; -. [Q8BQC3-2]
DR CCDS; CCDS90599.1; -. [Q8BQC3-1]
DR RefSeq; NP_033014.1; NM_008988.2. [Q8BQC3-2]
DR RefSeq; XP_006510936.1; XM_006510873.2.
DR AlphaFoldDB; Q8BQC3; -.
DR SMR; Q8BQC3; -.
DR IntAct; Q8BQC3; 1.
DR MINT; Q8BQC3; -.
DR STRING; 10090.ENSMUSP00000034961; -.
DR GlyGen; Q8BQC3; 7 sites.
DR iPTMnet; Q8BQC3; -.
DR PhosphoSitePlus; Q8BQC3; -.
DR PaxDb; Q8BQC3; -.
DR PRIDE; Q8BQC3; -.
DR ProteomicsDB; 267217; -. [Q8BQC3-1]
DR ProteomicsDB; 267218; -. [Q8BQC3-2]
DR Antibodypedia; 2652; 43 antibodies from 12 providers.
DR DNASU; 19289; -.
DR Ensembl; ENSMUST00000034961; ENSMUSP00000034961; ENSMUSG00000032394. [Q8BQC3-2]
DR Ensembl; ENSMUST00000217371; ENSMUSP00000149084; ENSMUSG00000032394. [Q8BQC3-1]
DR GeneID; 19289; -.
DR KEGG; mmu:19289; -.
DR UCSC; uc009qcv.1; mouse. [Q8BQC3-2]
DR UCSC; uc009qcw.1; mouse. [Q8BQC3-1]
DR CTD; 9543; -.
DR MGI; MGI:1202390; Igdcc3.
DR VEuPathDB; HostDB:ENSMUSG00000032394; -.
DR eggNOG; KOG4221; Eukaryota.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000156969; -.
DR HOGENOM; CLU_018612_2_0_1; -.
DR InParanoid; Q8BQC3; -.
DR OMA; CGLMEGK; -.
DR OrthoDB; 1010015at2759; -.
DR PhylomeDB; Q8BQC3; -.
DR TreeFam; TF321506; -.
DR BioGRID-ORCS; 19289; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Igdcc3; mouse.
DR PRO; PR:Q8BQC3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BQC3; protein.
DR Bgee; ENSMUSG00000032394; Expressed in embryonic post-anal tail and 96 other tissues.
DR Genevisible; Q8BQC3; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; -; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 3.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; SSF48726; 4.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..47
FT /evidence="ECO:0000255"
FT CHAIN 48..813
FT /note="Immunoglobulin superfamily DCC subclass member 3"
FT /id="PRO_0000014921"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..151
FT /note="Ig-like C2-type 1"
FT DOMAIN 151..232
FT /note="Ig-like C2-type 2"
FT DOMAIN 250..333
FT /note="Ig-like C2-type 3"
FT DOMAIN 341..428
FT /note="Ig-like C2-type 4"
FT DOMAIN 438..532
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 535..630
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 592
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 616
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 75..129
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 172..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 271..319
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 363..412
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 631..650
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9507132,
FT ECO:0000303|PubMed:9922388"
FT /id="VSP_012321"
SQ SEQUENCE 813 AA; 86460 MW; C707194FF617A916 CRC64;
MAEPRTASPR RLPALRRPGF LPPLLPPPPP PLLLLLLLLP LPAPSLGLGH SAELAFSVEP
NDDIANPGQP IVLGCKVEGT PPVQVSWRKN GAELPEGTHT TLLANGSLLI HHFRLEQGGS
PSDEGDYECV AQNRFGLLVS RKARLQAATM SDFHVHPQAV TGEEGGVARF QCQIHGLPKP
LITWEKNRVP IDTDDERYTL LPKGVLQITG LRAEDSGIFH CVASNIASVR VSHGARLTVS
GSGSGTYKEP TILVGPENLT LTVHQTAVLE CVATGNPRPI VSWSRLDGRP IGVEGIQVLG
TGNLIISDVT VQHSGVYVCA ANRPGTRVRR TAQGRLVVQA PAEFVQHPQS ISRPAGTTAM
FTCQAQGEPP PHVTWLKNGQ VLGAGGHVRL KNNNSTLSIS GVGPEDEAIY QCVAENIAGS
SQASARLTVL WAEGLPGPPR NVRAVSVSST EVRVSWSEPL AHTKEIIGYV LHIRKAADSP
KLEYQEAVSK STFQHLVRDL EPSTAYSFYI KAYTPRGASL ASVPTLASTL GEAPVPPPLS
VRLLGSSSLQ LLWKPWPRLA QHNGGFKLFY RPVSATSFTG PILLPGTVSS YNLSQLDPST
VYEVKLLAYN QHGDGNATVR FVSLKGASER TALTPPCDCR KEDVTNHTST TGIVIGIHIG
VTCIIFCVLF LLFGQRGRVL LCKDVENQLS PPQGPRSQRD PGILALNGLS RGEGGQLSRD
EKPVDAKELE QLFPTAGSAA QPGSTPTDPA APAPCEETQL SMVQLQGFNL VAGRTTEATS
PCAGPGPVPA PQDIGPVPLS EGQTQPPAVA APQ
