IGDC4_MOUSE
ID IGDC4_MOUSE Reviewed; 1252 AA.
AC Q9EQS9; Q80TB0; Q9EQS8; Q9JLI1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Immunoglobulin superfamily DCC subclass member 4;
DE AltName: Full=Neighbor of punc e11;
DE AltName: Full=Protein DDM36;
DE Flags: Precursor;
GN Name=Igdcc4; Synonyms=Ddm36, Kiaa1628, Nope;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RC STRAIN=FVB/NJ;
RX PubMed=10708514; DOI=10.1006/geno.2000.6114;
RA Salbaum J.M., Kappen C.;
RT "Cloning and expression of Nope, a new mouse gene of the immunoglobulin
RT superfamily related to guidance receptors.";
RL Genomics 64:15-23(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J X DBA;
RA Murakami H., Nakamata T., Nakayama T., Yamamoto H., Hosaka T., Aoyama T.,
RA Nagayama S., Oka M., Kiyono T., Sasaki M.S., Nakamura T., Toguchida J.;
RT "Up-regulation of a ras effector and down-regulation of a cell adhesion
RT molecule are associated with transformation of osteoblasts.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-1252 (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=Ddm36;
CC IsoId=Q9EQS9-1; Sequence=Displayed;
CC Name=2; Synonyms=Ddm36e;
CC IsoId=Q9EQS9-2; Sequence=VSP_028048;
CC Name=3;
CC IsoId=Q9EQS9-3; Sequence=VSP_028047;
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle, heart and brain.
CC Brain expression is hippocampus-specific.
CC {ECO:0000269|PubMed:10708514}.
CC -!- DEVELOPMENTAL STAGE: Expressed from 9.5 dpc. Expression is observed in
CC the developing embryo, especially in the notochord, in developing
CC skeletal muscles, and later in the ventricular zone of the nervous
CC system. {ECO:0000269|PubMed:10708514}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000305}.
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DR EMBL; AF176694; AAF65930.1; -; mRNA.
DR EMBL; AB052620; BAB19278.1; -; mRNA.
DR EMBL; AB052621; BAB19279.1; -; mRNA.
DR EMBL; AK122535; BAC65817.1; -; mRNA.
DR CCDS; CCDS72258.1; -. [Q9EQS9-2]
DR CCDS; CCDS90598.1; -. [Q9EQS9-1]
DR RefSeq; NP_001277244.1; NM_001290315.1. [Q9EQS9-2]
DR RefSeq; NP_064427.2; NM_020043.3. [Q9EQS9-1]
DR AlphaFoldDB; Q9EQS9; -.
DR SMR; Q9EQS9; -.
DR STRING; 10090.ENSMUSP00000076878; -.
DR GlyGen; Q9EQS9; 2 sites.
DR iPTMnet; Q9EQS9; -.
DR PhosphoSitePlus; Q9EQS9; -.
DR MaxQB; Q9EQS9; -.
DR PRIDE; Q9EQS9; -.
DR ProteomicsDB; 267291; -. [Q9EQS9-1]
DR ProteomicsDB; 267292; -. [Q9EQS9-2]
DR ProteomicsDB; 267293; -. [Q9EQS9-3]
DR Antibodypedia; 2317; 66 antibodies from 13 providers.
DR DNASU; 56741; -.
DR Ensembl; ENSMUST00000035499; ENSMUSP00000045387; ENSMUSG00000032816. [Q9EQS9-2]
DR Ensembl; ENSMUST00000213533; ENSMUSP00000150272; ENSMUSG00000032816. [Q9EQS9-1]
DR GeneID; 56741; -.
DR KEGG; mmu:56741; -.
DR UCSC; uc009qct.2; mouse. [Q9EQS9-1]
DR UCSC; uc009qcu.2; mouse. [Q9EQS9-2]
DR CTD; 57722; -.
DR MGI; MGI:1858497; Igdcc4.
DR VEuPathDB; HostDB:ENSMUSG00000032816; -.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000159637; -.
DR HOGENOM; CLU_006906_0_0_1; -.
DR InParanoid; Q9EQS9; -.
DR OMA; WDVGPIR; -.
DR OrthoDB; 1010015at2759; -.
DR PhylomeDB; Q9EQS9; -.
DR BioGRID-ORCS; 56741; 3 hits in 66 CRISPR screens.
DR ChiTaRS; Igdcc4; mouse.
DR PRO; PR:Q9EQS9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9EQS9; protein.
DR Bgee; ENSMUSG00000032816; Expressed in indifferent gonad and 249 other tissues.
DR ExpressionAtlas; Q9EQS9; baseline and differential.
DR Genevisible; Q9EQS9; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; ISA:MGI.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; -; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; SSF48726; 4.
DR SUPFAM; SSF49265; SSF49265; 3.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1252
FT /note="Immunoglobulin superfamily DCC subclass member 4"
FT /id="PRO_0000304623"
FT TOPO_DOM 23..956
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 957..977
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 978..1252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..136
FT /note="Ig-like 1"
FT DOMAIN 142..228
FT /note="Ig-like 2"
FT DOMAIN 241..329
FT /note="Ig-like 3"
FT DOMAIN 334..420
FT /note="Ig-like 4"
FT DOMAIN 430..524
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 526..622
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 631..742
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 751..844
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 849..944
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 669..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 994
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8TDY8"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 55..120
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 163..211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 264..311
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 355..404
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 280..377
FT /note="DGKPISTDVIVLGRTNLLIASAQPRHSGVYVCRANKPRTRDFATAAAELRVL
FT AAPAISQAPEALSRTRASTARFVCRASGEPRPALHWLHDGIPLRPN -> GDQSKKELG
FT IQTSGCDAALQGCSGNLVVGEGVEGTVPASPSSLLLLCHQMESLSPRMSSFWAGPIYSS
FT PARSLGTLESMSAEPTSPARVISPLRLLSSECLLPQPSRRRPRRSRGRGPAPRASCAGR
FT PGSHGPRCTGCTTGSRCDPM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10997877"
FT /id="VSP_028047"
FT VAR_SEQ 570
FT /note="E -> EE (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028048"
FT CONFLICT 9..20
FT /note="GLLVLTFCLLSA -> EGSQENPSAWHG (in Ref. 3; BAC65817)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="S -> P (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 193..195
FT /note="NGV -> KWL (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="S -> N (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="R -> L (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 665
FT /note="R -> G (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 711
FT /note="L -> P (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 944
FT /note="K -> E (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 979
FT /note="R -> Q (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
FT CONFLICT 1112
FT /note="A -> G (in Ref. 1; AAF65930)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1252 AA; 134765 MW; BA5292393483AB73 CRC64;
MARADTGRGL LVLTFCLLSA RGELPLPQET TVKLSCDEGP LQVILGPEQA VVLDCTLGAT
AAGPPTRVTW SKDGDTVLEH ENLHLLPNGS LWLSSPLEQE DSDDEEALRI WKVTEGSYSC
LAHSPLGVVA SQVAVVKLAT LEDFSLHPES QIVEENGTAR FECHTKGLPA PIITWEKDQV
TVPEESRLIT LPNGVLQILD VQDSDAGSYR CVATNSARQR FSQEASLTVA LRGSLEATRG
QDVVIVAAPE NTTVVSGQSV VMECVASADP TPFVSWVRQD GKPISTDVIV LGRTNLLIAS
AQPRHSGVYV CRANKPRTRD FATAAAELRV LAAPAISQAP EALSRTRAST ARFVCRASGE
PRPALHWLHD GIPLRPNGRV KVQGGGGSLV ITQIGLQDAG YYQCVAENSA GTACAAAPLA
VVVREGLPSA PTRVTATPLS SSSVLVAWER PELHSEQIIG FSLHYQKARG VDNVEYQFAV
NNDTTELQVR DLEPNTDYEF YVVAYSQLGA SRTSSPALVH TLDDVPSAAP QLTLSSPNPS
DIRVAWLPLP SSLSNGQVLK YKIEYGLGKE DQVFSTEVPG NETQLTLNSL QPNKVYRVRI
SAGTGAGYGV PSQWMQHRTP GVHNQSHVPF APAELKVRAK MESLVVSWQP PPHPTQISGY
KLYWREVGTE EEADGDRPPG GRGDQAWDVG PVRLKKKVKQ YELTQLVPGR LYEVKLVAFN
KHEDGYAAVW KGKTEKAPTP DLPIQRGPPL PPAHVHAESN SSTSIWLRWK KPDFTTVKIV
NYTVRFGPWG LRNASLVTYY TSSGEDILIG GLKPFTKYEF AVQSHGVDMD GPFGSVVERS
TLPDRPSTPP SDLRLSPLTP STVRLHWCPP TEPNGEIVEY LILYSNNHTQ PEHQWTLLTT
EGNIFSAEVH GLESDTRYFF KMGARTEVGP GPFSRLQDVI TLQKTFSDSL DVHAVTGIIV
GVCLGLLCLL ACMCAGLRRS SHREALPGLS SSGTPGNPAL YTRARLGPPS VPAAHELESL
VHPRPQDWSP PPSDVEDKAE VHSLMGGSVS DCRGHSKRKI SWAQAGGPNW AGSWAGCELP
QGSGPRPALT RALLPPAGTG QTLLLQALVY DAIKSNGRKK PSPACRNQVE AEVIVHSDFG
ASKGCPDLHL QDLEPEEPLT AETLPSTSGA VDLSQGADWL GRELGGCQPT TSGPERLTCL
PEAASASCSC SDLQPSTAIE EAPGKSCQPK ALCPLTVSPS LPRAPVSSAQ VP
