ID   4CLL6_ORYSJ             Reviewed;         598 AA.
AC   Q8RU95; A0A0P0VBX5;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=4-coumarate--CoA ligase-like 6;
DE            EC=6.2.1.-;
GN   Name=4CLL6; OrderedLocusNames=Os01g0901600, LOC_Os01g67540;
GN   ORFNames=B1065G12.10, P0551C06.10;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RG   The rice full-length cDNA consortium;
RT   "Oryza sativa full length cDNA.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=18627494; DOI=10.1111/j.1469-8137.2008.02534.x;
RA   de Azevedo Souza C., Barbazuk B., Ralph S.G., Bohlmann J., Hamberger B.,
RA   Douglas C.J.;
RT   "Genome-wide analysis of a land plant-specific acyl:coenzyme A synthetase
RT   (ACS) gene family in Arabidopsis, poplar, rice and Physcomitrella.";
RL   New Phytol. 179:987-1003(2008).
CC   -!- DOMAIN: Both substrate-binding domains (SBD1 and SBD2) are involved in
CC       the substrate recognition, and are sufficient to confer the substrate
CC       specificity.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB89961.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAB90528.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAD82770.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP003313; BAB89961.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP003791; BAB90528.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP006757; BAD82770.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014957; BAS75754.1; -; Genomic_DNA.
DR   EMBL; AK241420; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q8RU95; -.
DR   SMR; Q8RU95; -.
DR   STRING; 4530.OS01T0901600-01; -.
DR   PaxDb; Q8RU95; -.
DR   PRIDE; Q8RU95; -.
DR   EnsemblPlants; Os01t0901600-01; Os01t0901600-01; Os01g0901600.
DR   Gramene; Os01t0901600-01; Os01t0901600-01; Os01g0901600.
DR   eggNOG; KOG1176; Eukaryota.
DR   HOGENOM; CLU_000022_59_2_1; -.
DR   InParanoid; Q8RU95; -.
DR   OMA; TVPMVYD; -.
DR   PlantReactome; R-OSA-1119316; Phenylpropanoid biosynthesis.
DR   PlantReactome; R-OSA-1119531; Flavonoid biosynthesis.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   Genevisible; Q8RU95; OS.
DR   GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR   GO; GO:0106290; F:trans-cinnamate-CoA ligase activity; IEA:UniProt.
DR   GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Ligase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..598
FT                   /note="4-coumarate--CoA ligase-like 6"
FT                   /id="PRO_0000351632"
FT   REGION          320..389
FT                   /note="SBD1"
FT   REGION          390..454
FT                   /note="SBD2"
FT   BINDING         232..240
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         390..395
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         475
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         490
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         581
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   598 AA;  63258 MW;  56B7C37D12A686CB CRC64;
     MSKRSPPPQP AHIPMAEQRW RPPYPYASSA AGGGGVDRRS RSGFCAATRT FHSLRSVGPL
     PPEELPLTVA AYAFSLLSSA PPLVVAGRGP ALVDAATGIA VSYPAFVARV RFLAGGLWCS
     LGLRPGDVAL VVSPSCLDVA VLYFALMSIG VVVSPANPAS TADEYAHQVR LSRPAIAFVA
     PEVAARLPRH VSRVVIGSEV FDRLASASAA GGWAAPPAVA MKQPSTAALL YSSGTTGRVK
     AVAITHRNLI AQISAYNAIR ETVAREAATD AGKGKPPPPS PSPPAAVTLF PLPLFHVMGF
     GLLTRTISSG ETAVVMRRFD LAAAARAVER YRVTKLSAAP PVVVALTKSD EARRRDLSSL
     VAIVVGGAPL GREVSQRFAT VFPSVQIVQS YGLTESTGPV ATMAGPEESA AYGSVGRLAP
     RVQAKIVDTA TGEVLGPGRR GELWIRGPVV MKGYVGDPEA TAATITPDGW LKTGDLCYFN
     EDGYLYVVDR LKELIKYKGY QVPPAELEHI LQSRPEIADA AVVPYPDEEA GQLPMAFVVR
     QPGAYLTEQQ VMNCVAKHVA PYKKVRRVAF VNAIPKSPAG KILRRELVLQ AMASTSRL