IGF1_RABIT
ID IGF1_RABIT Reviewed; 143 AA.
AC Q95222; O18846;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 3.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Insulin-like growth factor I;
DE Short=IGF-I;
DE AltName: Full=Somatomedin;
DE Flags: Precursor;
GN Name=IGF1; Synonyms=IGF-1;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IGF-IA).
RC STRAIN=Zika;
RA Flekna G., Brem G., Mueller M.;
RL Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IGF-IB).
RC STRAIN=Zika; TISSUE=Liver;
RA Flekna G., Brem G., Mueller M.;
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The insulin-like growth factors, isolated from plasma, are
CC structurally and functionally related to insulin but have a much higher
CC growth-promoting activity. May be a physiological regulator of [1-14C]-
CC 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in
CC osteoblasts. Stimulates glucose transport in bone-derived osteoblastic
CC (PyMS) cells and is effective at much lower concentrations than
CC insulin, not only regarding glycogen and DNA synthesis but also with
CC regard to enhancing glucose uptake. May play a role in synapse
CC maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory
CC perception of smell in the olfactory bulb. Acts as a ligand for IGF1R.
CC Binds to the alpha subunit of IGF1R, leading to the activation of the
CC intrinsic tyrosine kinase activity which autophosphorylates tyrosine
CC residues in the beta subunit thus initiatiating a cascade of down-
CC stream signaling events leading to activation of the PI3K-AKT/PKB and
CC the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4.
CC Its binding to integrins and subsequent ternary complex formation with
CC integrins and IGFR1 are essential for IGF1 signaling. Induces the
CC phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and
CC AKT1 (By similarity). {ECO:0000250|UniProtKB:P05017,
CC ECO:0000250|UniProtKB:P05019}.
CC -!- SUBUNIT: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a
CC ternary complex with IGFR1 and ITGA6:ITGB4.
CC {ECO:0000250|UniProtKB:P05019}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05017}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=IGF-IB;
CC IsoId=Q95222-1; Sequence=Displayed;
CC Name=IGF-IA;
CC IsoId=Q95222-2; Sequence=VSP_002705;
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; U75390; AAB48032.1; -; mRNA.
DR EMBL; AF022961; AAB80950.1; -; mRNA.
DR RefSeq; NP_001075495.1; NM_001082026.1. [Q95222-1]
DR RefSeq; XP_008254942.1; XM_008256720.2. [Q95222-2]
DR AlphaFoldDB; Q95222; -.
DR SMR; Q95222; -.
DR STRING; 9986.ENSOCUP00000021389; -.
DR GeneID; 100008668; -.
DR KEGG; ocu:100008668; -.
DR CTD; 3479; -.
DR eggNOG; ENOG502RCAB; Eukaryota.
DR InParanoid; Q95222; -.
DR OrthoDB; 1644517at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0035867; C:alphav-beta3 integrin-IGF-1-IGF1R complex; ISS:UniProtKB.
DR GO; GO:0070382; C:exocytic vesicle; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..102
FT /note="Insulin-like growth factor I"
FT /id="PRO_0000015679"
FT PROPEP 103..143
FT /note="E peptide"
FT /id="PRO_0000015680"
FT REGION 33..61
FT /note="B"
FT REGION 62..73
FT /note="C"
FT REGION 74..94
FT /note="A"
FT REGION 95..102
FT /note="D"
FT REGION 99..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..80
FT /evidence="ECO:0000250"
FT DISULFID 50..93
FT /evidence="ECO:0000250"
FT DISULFID 79..84
FT /evidence="ECO:0000250"
FT VAR_SEQ 119..143
FT /note="YQPPSTNKKMKSQRRRKGSTFEEHK -> EVHLKNTSRGSAGNKNYRM (in
FT isoform IGF-IA)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_002705"
SQ SEQUENCE 143 AA; 16092 MW; 819AF577800A1B1A CRC64;
MITPTVKMRI LSSSHLFYLA LCLLTFTSSA TAGPETLCGA ELVDALQFVC GDRGFYFNKP
TGYGSSSRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPAK AARSVRAQRH TDMPKTQKYQ
PPSTNKKMKS QRRRKGSTFE EHK
