ID   IGF2_ONCMY              Reviewed;         214 AA.
AC   Q02816;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Insulin-like growth factor II;
DE            Short=IGF-II;
DE   AltName: Full=Erythrotropin;
DE   Flags: Precursor;
GN   Name=igf2;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=1409585; DOI=10.1073/pnas.89.19.8913;
RA   Shamblott M.J., Chen T.T.;
RT   "Identification of a second insulin-like growth factor in a fish species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:8913-8917(1992).
CC   -!- FUNCTION: The insulin-like growth factors, isolated from plasma, are
CC       structurally and functionally related to insulin but have a much higher
CC       growth-promoting activity. Acts as a ligand for integrin which is
CC       required for IGF2 signaling. {ECO:0000250|UniProtKB:P01344}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; M95184; AAA49411.1; -; mRNA.
DR   PIR; B46244; B46244.
DR   RefSeq; NP_001118169.1; NM_001124697.1.
DR   AlphaFoldDB; Q02816; -.
DR   PRIDE; Q02816; -.
DR   Ensembl; ENSOMYT00000028277; ENSOMYP00000025841; ENSOMYG00000012223.
DR   GeneID; 100136742; -.
DR   KEGG; omy:100136742; -.
DR   CTD; 324215; -.
DR   GeneTree; ENSGT00940000160745; -.
DR   OrthoDB; 1644517at2759; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR022334; IGF2.
DR   InterPro; IPR013576; IGF2_C.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR022350; Insulin-like_growth_factor.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF08365; IGF2_C; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02002; INSLNLIKEGF.
DR   PRINTS; PR02006; INSLNLIKEGF2.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Secreted; Signal.
FT   SIGNAL          1..?
FT   PROPEP          ?..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000015724"
FT   CHAIN           48..117
FT                   /note="Insulin-like growth factor II"
FT                   /id="PRO_0000015725"
FT   PROPEP          118..214
FT                   /note="E peptide"
FT                   /id="PRO_0000015726"
FT   REGION          48..79
FT                   /note="B"
FT   REGION          80..90
FT                   /note="C"
FT   REGION          91..111
FT                   /note="A"
FT   REGION          112..117
FT                   /note="D"
FT   SITE            71
FT                   /note="Important for interaction with integrin"
FT                   /evidence="ECO:0000250|UniProtKB:P01344"
FT   SITE            81
FT                   /note="Important for interaction with integrin"
FT                   /evidence="ECO:0000250|UniProtKB:P01344"
FT   SITE            86
FT                   /note="Important for interaction with integrin"
FT                   /evidence="ECO:0000250|UniProtKB:P01344"
FT   DISULFID        56..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        96..101
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   214 AA;  24637 MW;  FF8CCB173314C8FA CRC64;
     METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA SAETLCGGEL
     VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS CDLNLLEQYC AKPAKSERDV
     SATSLQIIPM VPTIKQDVPR KHVTVKYSKY EAWQRKAAQR LRRGVPAILR ARKFRRQAVK
     IKAQEQAMFH RPLITLPSKL PPVLPPTDNY VSHN