ID   IGF3_XENLA              Reviewed;         127 AA.
AC   Q90WX8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Insulin-like growth factor III;
DE            Short=IGF-III;
DE   AltName: Full=Insulin-like growth factor 3;
DE            Short=xIGF-3;
DE   Flags: Precursor;
GN   Name=igf3 {ECO:0000250|UniProtKB:P01344};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAL06242.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11709186; DOI=10.1016/s1534-5807(01)00069-7;
RA   Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.;
RT   "Neural and head induction by insulin-like growth factor signals.";
RL   Dev. Cell 1:655-665(2001).
CC   -!- FUNCTION: The insulin-like growth factors, isolated from plasma, are
CC       structurally and functionally related to insulin but have a much higher
CC       growth-promoting activity. Promotes anterior neural development.
CC       {ECO:0000269|PubMed:11709186, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Expressed in the dorsal midline during gastrulation and neurulation.
CC       Expression is strong in the prospective ventral forebrain region of the
CC       anterior neural plate. {ECO:0000269|PubMed:11709186}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000255}.
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DR   EMBL; AY049735; AAL06242.1; -; mRNA.
DR   RefSeq; NP_001082137.1; NM_001088668.1.
DR   AlphaFoldDB; Q90WX8; -.
DR   GeneID; 398245; -.
DR   KEGG; xla:398245; -.
DR   CTD; 398245; -.
DR   Xenbase; XB-GENE-5807497; igf3.L.
DR   OrthoDB; 1644517at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 398245; Expressed in liver and 9 other tissues.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IDA:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0048699; P:generation of neurons; IDA:UniProtKB.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Disulfide bond; Growth factor;
KW   Neurogenesis; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..49
FT                   /evidence="ECO:0000255"
FT   CHAIN           50..121
FT                   /note="Insulin-like growth factor III"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000224643"
FT   PROPEP          122..127
FT                   /note="E peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000224644"
FT   REGION          49..80
FT                   /note="B"
FT                   /evidence="ECO:0000255"
FT   REGION          81..92
FT                   /note="C"
FT                   /evidence="ECO:0000255"
FT   REGION          93..113
FT                   /note="A"
FT                   /evidence="ECO:0000255"
FT   REGION          114..121
FT                   /note="D"
FT                   /evidence="ECO:0000255"
FT   DISULFID        61..99
FT                   /evidence="ECO:0000250|UniProtKB:P01344"
FT   DISULFID        73..112
FT                   /evidence="ECO:0000250|UniProtKB:P01344"
FT   DISULFID        98..103
FT                   /evidence="ECO:0000250|UniProtKB:P01344"
SQ   SEQUENCE   127 AA;  14144 MW;  D036240AEBC70C98 CRC64;
     MPVTAMCLQD SKKLKKAKLT RKKVTPFPFS RMVLCLSLVF TLYVEATNAR CLRPRSKELL
     CGSELVDILQ FICGPTGFYV SKGASFRNRN RPGIVEECCF CGCSVAILES YCAAPVTNFT
     GREEQKS