ID   IGFL1_HUMAN             Reviewed;         110 AA.
AC   Q6UW32;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Insulin growth factor-like family member 1;
DE   Flags: Precursor;
GN   Name=IGFL1; ORFNames=UNQ644/PRO1274;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=16890402; DOI=10.1016/j.ygeno.2006.05.012;
RA   Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B.,
RA   Hazell S., Polizotto R., Funk W.D., Tang Y.T.;
RT   "IGFL: a secreted family with conserved cysteine residues and similarities
RT   to the IGF superfamily.";
RL   Genomics 88:513-520(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 25-39.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, HOMODIMERIZATION, AND DISULFIDE BONDS.
RX   PubMed=21454693; DOI=10.1074/jbc.m111.224626;
RA   Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J.,
RA   Ouyang W., Gonzalez L.C.;
RT   "Murine IGFL and human IGFL1 are induced in inflammatory skin conditions
RT   and bind to a novel TNF receptor family member, IGFLR1.";
RL   J. Biol. Chem. 286:18969-18981(2011).
CC   -!- FUNCTION: Probable ligand of the IGFLR1 cell membrane receptor.
CC       {ECO:0000269|PubMed:21454693}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:21454693}.
CC   -!- INTERACTION:
CC       Q6UW32; P49639: HOXA1; NbExp=3; IntAct=EBI-3870426, EBI-740785;
CC       Q6UW32; Q9H665: IGFLR1; NbExp=5; IntAct=EBI-3870426, EBI-3870439;
CC       Q6UW32; Q12837: POU4F2; NbExp=3; IntAct=EBI-3870426, EBI-17236143;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16890402,
CC       ECO:0000269|PubMed:21454693}.
CC   -!- TISSUE SPECIFICITY: Detected in ovary and spinal cord.
CC       {ECO:0000269|PubMed:16890402}.
CC   -!- SIMILARITY: Belongs to the IGFL family. {ECO:0000305}.
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DR   EMBL; AY672111; AAT77785.1; -; mRNA.
DR   EMBL; AY359013; AAQ89372.1; -; mRNA.
DR   EMBL; AC006262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46123.1; -.
DR   RefSeq; NP_940943.1; NM_198541.1.
DR   AlphaFoldDB; Q6UW32; -.
DR   BioGRID; 131937; 83.
DR   IntAct; Q6UW32; 3.
DR   STRING; 9606.ENSP00000415823; -.
DR   GlyGen; Q6UW32; 1 site.
DR   BioMuta; IGFL1; -.
DR   DMDM; 74738058; -.
DR   MassIVE; Q6UW32; -.
DR   MaxQB; Q6UW32; -.
DR   PaxDb; Q6UW32; -.
DR   PeptideAtlas; Q6UW32; -.
DR   PRIDE; Q6UW32; -.
DR   ProteomicsDB; 67444; -.
DR   Antibodypedia; 2718; 44 antibodies from 17 providers.
DR   DNASU; 374918; -.
DR   Ensembl; ENST00000437936.2; ENSP00000415823.1; ENSG00000188293.6.
DR   GeneID; 374918; -.
DR   KEGG; hsa:374918; -.
DR   MANE-Select; ENST00000437936.2; ENSP00000415823.1; NM_198541.2; NP_940943.1.
DR   UCSC; uc002pee.3; human.
DR   CTD; 374918; -.
DR   DisGeNET; 374918; -.
DR   GeneCards; IGFL1; -.
DR   HGNC; HGNC:24093; IGFL1.
DR   HPA; ENSG00000188293; Group enriched (esophagus, salivary gland, vagina).
DR   MIM; 610544; gene.
DR   neXtProt; NX_Q6UW32; -.
DR   OpenTargets; ENSG00000188293; -.
DR   PharmGKB; PA147357921; -.
DR   VEuPathDB; HostDB:ENSG00000188293; -.
DR   eggNOG; ENOG502TJ2N; Eukaryota.
DR   GeneTree; ENSGT00390000009557; -.
DR   HOGENOM; CLU_148773_1_1_1; -.
DR   InParanoid; Q6UW32; -.
DR   OMA; ITPYLML; -.
DR   OrthoDB; 1479937at2759; -.
DR   PhylomeDB; Q6UW32; -.
DR   TreeFam; TF343427; -.
DR   PathwayCommons; Q6UW32; -.
DR   SignaLink; Q6UW32; -.
DR   BioGRID-ORCS; 374918; 15 hits in 1062 CRISPR screens.
DR   GenomeRNAi; 374918; -.
DR   Pharos; Q6UW32; Tdark.
DR   PRO; PR:Q6UW32; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6UW32; protein.
DR   Bgee; ENSG00000188293; Expressed in lower esophagus mucosa and 64 other tissues.
DR   Genevisible; Q6UW32; HS.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   InterPro; IPR032744; IGFL.
DR   PANTHER; PTHR34827; PTHR34827; 1.
DR   Pfam; PF14653; IGFL; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:15340161"
FT   CHAIN           25..110
FT                   /note="Insulin growth factor-like family member 1"
FT                   /id="PRO_0000044633"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   110 AA;  12363 MW;  51087608C0D5949E CRC64;
     MAPRGCIVAV FAIFCISRLL CSHGAPVAPM TPYLMLCQPH KRCGDKFYDP LQHCCYDDAV
     VPLARTQTCG NCTFRVCFEQ CCPWTFMVKL INQNCDSART SDDRLCRSVS