ID   IGFL2_HUMAN             Reviewed;         119 AA.
AC   Q6UWQ7; E9PAV1; Q6B9Z3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Insulin growth factor-like family member 2;
DE   Flags: Precursor;
GN   Name=IGFL2; ORFNames=UNQ645/PRO1275;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX   PubMed=16890402; DOI=10.1016/j.ygeno.2006.05.012;
RA   Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B.,
RA   Hazell S., Polizotto R., Funk W.D., Tang Y.T.;
RT   "IGFL: a secreted family with conserved cysteine residues and similarities
RT   to the IGF superfamily.";
RL   Genomics 88:513-520(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=21454693; DOI=10.1074/jbc.m111.224626;
RA   Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J.,
RA   Ouyang W., Gonzalez L.C.;
RT   "Murine IGFL and human IGFL1 are induced in inflammatory skin conditions
RT   and bind to a novel TNF receptor family member, IGFLR1.";
RL   J. Biol. Chem. 286:18969-18981(2011).
CC   -!- FUNCTION: Potential ligand of the IGFLR1 cell membrane receptor.
CC       {ECO:0000269|PubMed:21454693}.
CC   -!- INTERACTION:
CC       Q6UWQ7-2; P78337: PITX1; NbExp=3; IntAct=EBI-18115692, EBI-748265;
CC       Q6UWQ7-2; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-18115692, EBI-12069346;
CC       Q6UWQ7-2; O43711: TLX3; NbExp=3; IntAct=EBI-18115692, EBI-3939165;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6UWQ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6UWQ7-2; Sequence=VSP_016606;
CC   -!- TISSUE SPECIFICITY: Detected in cerebellum, heart, placenta, spleen,
CC       stomach, testis and thymus. {ECO:0000269|PubMed:16890402}.
CC   -!- SIMILARITY: Belongs to the IGFL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT77786.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY672112; AAT77786.1; ALT_INIT; mRNA.
DR   EMBL; AY358692; AAQ89055.1; -; mRNA.
DR   EMBL; AC007785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46121.1; -. [Q6UWQ7-1]
DR   CCDS; CCDS46122.1; -. [Q6UWQ7-2]
DR   RefSeq; NP_001002915.2; NM_001002915.2. [Q6UWQ7-2]
DR   RefSeq; NP_001128585.1; NM_001135113.1. [Q6UWQ7-1]
DR   RefSeq; XP_011524803.1; XM_011526501.1. [Q6UWQ7-2]
DR   RefSeq; XP_016881824.1; XM_017026335.1.
DR   AlphaFoldDB; Q6UWQ7; -.
DR   BioGRID; 127097; 3.
DR   IntAct; Q6UWQ7; 4.
DR   STRING; 9606.ENSP00000395219; -.
DR   BioMuta; IGFL2; -.
DR   MassIVE; Q6UWQ7; -.
DR   PaxDb; Q6UWQ7; -.
DR   PeptideAtlas; Q6UWQ7; -.
DR   PRIDE; Q6UWQ7; -.
DR   ProteomicsDB; 67515; -. [Q6UWQ7-2]
DR   TopDownProteomics; Q6UWQ7-1; -. [Q6UWQ7-1]
DR   Antibodypedia; 62142; 53 antibodies from 16 providers.
DR   DNASU; 147920; -.
DR   Ensembl; ENST00000377693.5; ENSP00000366922.3; ENSG00000204866.9. [Q6UWQ7-1]
DR   Ensembl; ENST00000434646.6; ENSP00000395219.1; ENSG00000204866.9. [Q6UWQ7-2]
DR   GeneID; 147920; -.
DR   KEGG; hsa:147920; -.
DR   MANE-Select; ENST00000377693.5; ENSP00000366922.3; NM_001135113.2; NP_001128585.1.
DR   UCSC; uc002peb.4; human. [Q6UWQ7-1]
DR   CTD; 147920; -.
DR   GeneCards; IGFL2; -.
DR   HGNC; HGNC:32929; IGFL2.
DR   HPA; ENSG00000204866; Tissue enriched (skin).
DR   MIM; 610545; gene.
DR   neXtProt; NX_Q6UWQ7; -.
DR   OpenTargets; ENSG00000204866; -.
DR   PharmGKB; PA147357935; -.
DR   VEuPathDB; HostDB:ENSG00000204866; -.
DR   eggNOG; ENOG502TJ2N; Eukaryota.
DR   GeneTree; ENSGT00390000009557; -.
DR   InParanoid; Q6UWQ7; -.
DR   OMA; MRTDYPR; -.
DR   PhylomeDB; Q6UWQ7; -.
DR   TreeFam; TF343427; -.
DR   PathwayCommons; Q6UWQ7; -.
DR   SignaLink; Q6UWQ7; -.
DR   BioGRID-ORCS; 147920; 14 hits in 1067 CRISPR screens.
DR   ChiTaRS; IGFL2; human.
DR   GenomeRNAi; 147920; -.
DR   Pharos; Q6UWQ7; Tdark.
DR   PRO; PR:Q6UWQ7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6UWQ7; protein.
DR   Bgee; ENSG00000204866; Expressed in upper arm skin and 95 other tissues.
DR   ExpressionAtlas; Q6UWQ7; baseline and differential.
DR   Genevisible; Q6UWQ7; HS.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
DR   InterPro; IPR032744; IGFL.
DR   PANTHER; PTHR34827; PTHR34827; 1.
DR   Pfam; PF14653; IGFL; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..119
FT                   /note="Insulin growth factor-like family member 2"
FT                   /id="PRO_0000045061"
FT   VAR_SEQ         1..6
FT                   /note="MVPRIF -> MRFSVSGMRTDYPRSVL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16890402"
FT                   /id="VSP_016606"
SQ   SEQUENCE   119 AA;  13248 MW;  6CF304D7104A67C7 CRC64;
     MVPRIFAPAY VSVCLLLLCP REVIAPAGSE PWLCQPAPRC GDKIYNPLEQ CCYNDAIVSL
     SETRQCGPPC TFWPCFELCC LDSFGLTNDF VVKLKVQGVN SQCHSSPISS KCESRRRFP