ID   IGFL3_HUMAN             Reviewed;         125 AA.
AC   Q6UXB1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Insulin growth factor-like family member 3;
DE   Flags: Precursor;
GN   Name=IGFL3; ORFNames=UNQ483/PRO982;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16890402; DOI=10.1016/j.ygeno.2006.05.012;
RA   Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B.,
RA   Hazell S., Polizotto R., Funk W.D., Tang Y.T.;
RT   "IGFL: a secreted family with conserved cysteine residues and similarities
RT   to the IGF superfamily.";
RL   Genomics 88:513-520(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 25-39.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=21454693; DOI=10.1074/jbc.m111.224626;
RA   Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J.,
RA   Ouyang W., Gonzalez L.C.;
RT   "Murine IGFL and human IGFL1 are induced in inflammatory skin conditions
RT   and bind to a novel TNF receptor family member, IGFLR1.";
RL   J. Biol. Chem. 286:18969-18981(2011).
CC   -!- FUNCTION: Potential ligand of the IGFLR1 cell membrane receptor.
CC       {ECO:0000269|PubMed:21454693}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in the cerebellum.
CC       {ECO:0000269|PubMed:16890402}.
CC   -!- SIMILARITY: Belongs to the IGFL family. {ECO:0000305}.
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DR   EMBL; AY672113; AAT77787.1; -; mRNA.
DR   EMBL; AY358434; AAQ88800.1; -; mRNA.
DR   EMBL; AC007785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS33058.1; -.
DR   RefSeq; NP_997276.1; NM_207393.1.
DR   AlphaFoldDB; Q6UXB1; -.
DR   BioGRID; 132739; 74.
DR   IntAct; Q6UXB1; 1.
DR   STRING; 9606.ENSP00000344860; -.
DR   BioMuta; IGFL3; -.
DR   DMDM; 74738197; -.
DR   MassIVE; Q6UXB1; -.
DR   PaxDb; Q6UXB1; -.
DR   PeptideAtlas; Q6UXB1; -.
DR   PRIDE; Q6UXB1; -.
DR   ProteomicsDB; 67582; -.
DR   Antibodypedia; 67448; 43 antibodies from 16 providers.
DR   DNASU; 388555; -.
DR   Ensembl; ENST00000341415.3; ENSP00000344860.2; ENSG00000188624.3.
DR   GeneID; 388555; -.
DR   KEGG; hsa:388555; -.
DR   MANE-Select; ENST00000341415.3; ENSP00000344860.2; NM_207393.2; NP_997276.1.
DR   UCSC; uc002pea.1; human.
DR   CTD; 388555; -.
DR   GeneCards; IGFL3; -.
DR   HGNC; HGNC:32930; IGFL3.
DR   HPA; ENSG00000188624; Tissue enriched (skin).
DR   MIM; 610546; gene.
DR   neXtProt; NX_Q6UXB1; -.
DR   OpenTargets; ENSG00000188624; -.
DR   PharmGKB; PA147357949; -.
DR   VEuPathDB; HostDB:ENSG00000188624; -.
DR   eggNOG; ENOG502TJ2N; Eukaryota.
DR   GeneTree; ENSGT00390000009557; -.
DR   HOGENOM; CLU_148773_1_0_1; -.
DR   InParanoid; Q6UXB1; -.
DR   OMA; WGITVFL; -.
DR   OrthoDB; 1479937at2759; -.
DR   PhylomeDB; Q6UXB1; -.
DR   TreeFam; TF343427; -.
DR   PathwayCommons; Q6UXB1; -.
DR   SignaLink; Q6UXB1; -.
DR   BioGRID-ORCS; 388555; 11 hits in 1054 CRISPR screens.
DR   GenomeRNAi; 388555; -.
DR   Pharos; Q6UXB1; Tdark.
DR   PRO; PR:Q6UXB1; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6UXB1; protein.
DR   Bgee; ENSG00000188624; Expressed in skin of leg and 56 other tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
DR   InterPro; IPR032744; IGFL.
DR   PANTHER; PTHR34827; PTHR34827; 1.
DR   Pfam; PF14653; IGFL; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:15340161"
FT   CHAIN           25..125
FT                   /note="Insulin growth factor-like family member 3"
FT                   /id="PRO_0000044634"
FT   VARIANT         66
FT                   /note="T -> S (in dbSNP:rs10406448)"
FT                   /id="VAR_034012"
SQ   SEQUENCE   125 AA;  14198 MW;  57CE1D166779090D CRC64;
     MRPRCCILAL VCWITVFLLQ CSKGTTDAPV GSGLWLCQPT PRCGNKIYNP SEQCCYDDAI
     LSLKETRRCG STCTFWPCFE LCCPESFGPQ QKFLVKLRVL GMKSQCHLSP ISRSCTRNRR
     HVLYP