ID   IGFL4_HUMAN             Reviewed;         124 AA.
AC   Q6B9Z1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Insulin growth factor-like family member 4;
DE   Flags: Precursor;
GN   Name=IGFL4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16890402; DOI=10.1016/j.ygeno.2006.05.012;
RA   Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B.,
RA   Hazell S., Polizotto R., Funk W.D., Tang Y.T.;
RT   "IGFL: a secreted family with conserved cysteine residues and similarities
RT   to the IGF superfamily.";
RL   Genomics 88:513-520(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in the cerebellum.
CC       {ECO:0000269|PubMed:16890402}.
CC   -!- SIMILARITY: Belongs to the IGFL family. {ECO:0000305}.
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DR   EMBL; AY672114; AAT77788.1; -; mRNA.
DR   EMBL; AC007785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS33057.1; -.
DR   RefSeq; NP_001002923.1; NM_001002923.1.
DR   AlphaFoldDB; Q6B9Z1; -.
DR   GlyGen; Q6B9Z1; 2 sites.
DR   BioMuta; IGFL4; -.
DR   DMDM; 74709209; -.
DR   PaxDb; Q6B9Z1; -.
DR   PRIDE; Q6B9Z1; -.
DR   Antibodypedia; 62140; 40 antibodies from 13 providers.
DR   DNASU; 444882; -.
DR   Ensembl; ENST00000377697.2; ENSP00000366926.1; ENSG00000204869.9.
DR   GeneID; 444882; -.
DR   KEGG; hsa:444882; -.
DR   MANE-Select; ENST00000377697.2; ENSP00000366926.1; NM_001002923.3; NP_001002923.1.
DR   UCSC; uc002pdy.1; human.
DR   CTD; 444882; -.
DR   DisGeNET; 444882; -.
DR   GeneCards; IGFL4; -.
DR   HGNC; HGNC:32931; IGFL4.
DR   HPA; ENSG00000204869; Group enriched (retina, skin).
DR   MIM; 610547; gene.
DR   neXtProt; NX_Q6B9Z1; -.
DR   OpenTargets; ENSG00000204869; -.
DR   PharmGKB; PA147357961; -.
DR   VEuPathDB; HostDB:ENSG00000204869; -.
DR   eggNOG; ENOG502TJ2N; Eukaryota.
DR   GeneTree; ENSGT00390000009557; -.
DR   HOGENOM; CLU_148773_0_0_1; -.
DR   InParanoid; Q6B9Z1; -.
DR   OMA; QTRLCGP; -.
DR   OrthoDB; 1479937at2759; -.
DR   PhylomeDB; Q6B9Z1; -.
DR   TreeFam; TF343427; -.
DR   PathwayCommons; Q6B9Z1; -.
DR   SignaLink; Q6B9Z1; -.
DR   BioGRID-ORCS; 444882; 8 hits in 1058 CRISPR screens.
DR   GenomeRNAi; 444882; -.
DR   Pharos; Q6B9Z1; Tdark.
DR   PRO; PR:Q6B9Z1; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6B9Z1; protein.
DR   Bgee; ENSG00000204869; Expressed in primary visual cortex and 89 other tissues.
DR   ExpressionAtlas; Q6B9Z1; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   InterPro; IPR032744; IGFL.
DR   PANTHER; PTHR34827; PTHR34827; 1.
DR   Pfam; PF14653; IGFL; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..124
FT                   /note="Insulin growth factor-like family member 4"
FT                   /id="PRO_0000045062"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         25
FT                   /note="L -> P (in dbSNP:rs10412490)"
FT                   /id="VAR_049571"
FT   VARIANT         60
FT                   /note="R -> Q (in dbSNP:rs17271272)"
FT                   /id="VAR_049572"
SQ   SEQUENCE   124 AA;  13885 MW;  FBBFB971350A330E CRC64;
     MVPRISAAIF IFELLGSNSE GVTDLRLWLC QPAPRCGEWT YNPLEQCCDD GVILDLNQTR
     LCGSSCTFWP CFQHCCLESL GSQNQTVVRF KVPGMKPDCK SSPITRICAQ EYHPKSPVSR
     SDLI