ID   IGFL_MOUSE              Reviewed;         140 AA.
AC   Q6B9Z0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Insulin growth factor-like family member;
DE   Flags: Precursor;
GN   Name=Igfl; Synonyms=Gm580, Igfl3, mIgfl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=16890402; DOI=10.1016/j.ygeno.2006.05.012;
RA   Emtage P., Vatta P., Arterburn M., Muller M.W., Park E., Boyle B.,
RA   Hazell S., Polizotto R., Funk W.D., Tang Y.T.;
RT   "IGFL: a secreted family with conserved cysteine residues and similarities
RT   to the IGF superfamily.";
RL   Genomics 88:513-520(2006).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, HOMODIMERIZATION, DISULFIDE BONDS, TISSUE
RP   SPECIFICITY, AND INDUCTION BY IMIQUIMOD.
RX   PubMed=21454693; DOI=10.1074/jbc.m111.224626;
RA   Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J.,
RA   Ouyang W., Gonzalez L.C.;
RT   "Murine IGFL and human IGFL1 are induced in inflammatory skin conditions
RT   and bind to a novel TNF receptor family member, IGFLR1.";
RL   J. Biol. Chem. 286:18969-18981(2011).
CC   -!- FUNCTION: Probable ligand of the IGFLR1 cell membrane receptor.
CC       {ECO:0000269|PubMed:21454693}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:21454693}.
CC   -!- INTERACTION:
CC       Q6B9Z0; Q3U4N7: Igflr1; NbExp=3; IntAct=EBI-3870418, EBI-3870498;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21454693}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in skin. Also detected in colon,
CC       thymus, mammary gland, lymph node and lung.
CC       {ECO:0000269|PubMed:21454693}.
CC   -!- INDUCTION: Up-regulated by Imiquimod. Up-regulated in skin upon tissue
CC       inflammation and injury. {ECO:0000269|PubMed:21454693}.
CC   -!- SIMILARITY: Belongs to the IGFL family. {ECO:0000305}.
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DR   EMBL; AY672115; AAT77789.1; -; mRNA.
DR   CCDS; CCDS52049.1; -.
DR   RefSeq; NP_001003393.1; NM_001003393.1.
DR   AlphaFoldDB; Q6B9Z0; -.
DR   IntAct; Q6B9Z0; 1.
DR   STRING; 10090.ENSMUSP00000123628; -.
DR   PaxDb; Q6B9Z0; -.
DR   PRIDE; Q6B9Z0; -.
DR   DNASU; 232925; -.
DR   Ensembl; ENSMUST00000152973; ENSMUSP00000123628; ENSMUSG00000066756.
DR   GeneID; 232925; -.
DR   KEGG; mmu:232925; -.
DR   UCSC; uc009fjg.1; mouse.
DR   CTD; 388555; -.
DR   MGI; MGI:2685426; Igfl3.
DR   VEuPathDB; HostDB:ENSMUSG00000066756; -.
DR   GeneTree; ENSGT00390000009557; -.
DR   HOGENOM; CLU_148773_1_0_1; -.
DR   InParanoid; Q6B9Z0; -.
DR   OMA; PISRNCK; -.
DR   OrthoDB; 1479937at2759; -.
DR   PhylomeDB; Q6B9Z0; -.
DR   TreeFam; TF343427; -.
DR   BioGRID-ORCS; 232925; 1 hit in 71 CRISPR screens.
DR   PRO; PR:Q6B9Z0; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q6B9Z0; protein.
DR   Bgee; ENSMUSG00000066756; Expressed in zone of skin and 2 other tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR   InterPro; IPR032744; IGFL.
DR   PANTHER; PTHR34827; PTHR34827; 1.
DR   Pfam; PF14653; IGFL; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..140
FT                   /note="Insulin growth factor-like family member"
FT                   /id="PRO_0000045063"
SQ   SEQUENCE   140 AA;  15667 MW;  DE22EF8D4651FB19 CRC64;
     MKIRNACAVL IEVLLFILEG VTGARKISTF SGPGSWPCNP KCDGRTYNPS EECCVHDTIL
     PFKRINLCGP SCTYRPCFEL CCPESYSPKK KFIVKLKVHG ERSHCSSSPI SRNCKSNKIF
     HGEDIEDNQL SLRKKSGDQP