IGFN1_MOUSE
ID IGFN1_MOUSE Reviewed; 2849 AA.
AC Q3KNY0; Q8BZ74;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1;
GN Name=Igfn1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), NUCLEOTIDE SEQUENCE
RP [MRNA] OF 122-2836 (ISOFORM 4), INTERACTION WITH FLNC AND KY, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=C3H/HeJ, and C57BL/6J; TISSUE=Skeletal muscle;
RX PubMed=20206623; DOI=10.1016/j.yexcr.2010.02.027;
RA Baker J., Riley G., Romero M.R., Haynes A.R., Hilton H., Simon M.,
RA Hancock J., Tateossian H., Ripoll V.M., Blanco G.;
RT "Identification of a Z-band associated protein complex involving KY, FLNC
RT and IGFN1.";
RL Exp. Cell Res. 316:1856-1870(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2560-2849 (ISOFORM 1/2/3/4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with FLNC. Interacts with KY.
CC {ECO:0000269|PubMed:20206623}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20206623}. Cytoplasm,
CC myofibril, sarcomere, Z line {ECO:0000269|PubMed:20206623}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=IGFN1;
CC IsoId=Q3KNY0-1; Sequence=Displayed;
CC Name=2; Synonyms=IGFN1_v2;
CC IsoId=Q3KNY0-2; Sequence=VSP_039842;
CC Name=3; Synonyms=IGFN1_v3;
CC IsoId=Q3KNY0-3; Sequence=VSP_035062, VSP_035065;
CC Name=4; Synonyms=IGFN1_v1;
CC IsoId=Q3KNY0-4; Sequence=VSP_039843;
CC Name=5;
CC IsoId=Q3KNY0-5; Sequence=VSP_035061;
CC -!- TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 4 are expressed in
CC skeletal muscle while isoform 2 is detected in both skeletal muscle and
CC heart (at protein level). {ECO:0000269|PubMed:20206623}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI07028.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI07029.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; EU429481; ACA28707.1; -; mRNA.
DR EMBL; EU429482; ACA28708.1; -; mRNA.
DR EMBL; EU429483; ACA28709.2; -; mRNA.
DR EMBL; GU290042; ADB78700.1; -; mRNA.
DR EMBL; AK036509; BAC29455.1; -; mRNA.
DR EMBL; AC108813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107027; AAI07028.1; ALT_INIT; mRNA.
DR EMBL; BC107028; AAI07029.1; ALT_INIT; mRNA.
DR CCDS; CCDS48379.1; -. [Q3KNY0-1]
DR RefSeq; NP_808310.2; NM_177642.3. [Q3KNY0-1]
DR RefSeq; XP_017175436.1; XM_017319947.1. [Q3KNY0-3]
DR BioGRID; 230514; 1.
DR CORUM; Q3KNY0; -.
DR STRING; 10090.ENSMUSP00000129680; -.
DR iPTMnet; Q3KNY0; -.
DR PhosphoSitePlus; Q3KNY0; -.
DR jPOST; Q3KNY0; -.
DR PaxDb; Q3KNY0; -.
DR PeptideAtlas; Q3KNY0; -.
DR PRIDE; Q3KNY0; -.
DR ProteomicsDB; 269460; -. [Q3KNY0-1]
DR ProteomicsDB; 269461; -. [Q3KNY0-2]
DR ProteomicsDB; 269462; -. [Q3KNY0-3]
DR ProteomicsDB; 269463; -. [Q3KNY0-4]
DR ProteomicsDB; 269464; -. [Q3KNY0-5]
DR Antibodypedia; 34499; 98 antibodies from 15 providers.
DR DNASU; 226438; -.
DR Ensembl; ENSMUST00000166193; ENSMUSP00000129680; ENSMUSG00000051985. [Q3KNY0-1]
DR GeneID; 226438; -.
DR KEGG; mmu:226438; -.
DR UCSC; uc007cuc.2; mouse. [Q3KNY0-3]
DR UCSC; uc011wst.1; mouse. [Q3KNY0-1]
DR UCSC; uc011wsu.1; mouse. [Q3KNY0-4]
DR CTD; 91156; -.
DR MGI; MGI:3045352; Igfn1.
DR VEuPathDB; HostDB:ENSMUSG00000051985; -.
DR eggNOG; KOG0613; Eukaryota.
DR GeneTree; ENSGT00940000162073; -.
DR HOGENOM; CLU_000240_0_0_1; -.
DR InParanoid; Q3KNY0; -.
DR OMA; LGAPKGM; -.
DR OrthoDB; 103399at2759; -.
DR PhylomeDB; Q3KNY0; -.
DR BioGRID-ORCS; 226438; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Igfn1; mouse.
DR PRO; PR:Q3KNY0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3KNY0; protein.
DR Bgee; ENSMUSG00000051985; Expressed in quadriceps femoris and 11 other tissues.
DR ExpressionAtlas; Q3KNY0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IDA:UniProtKB.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0010842; P:retina layer formation; IBA:GO_Central.
DR GO; GO:0007416; P:synapse assembly; IBA:GO_Central.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; -; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040849; MyBP-C_THB.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF18362; THB; 1.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 6.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Immunoglobulin domain;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..2849
FT /note="Immunoglobulin-like and fibronectin type III domain-
FT containing protein 1"
FT /id="PRO_0000347187"
FT DOMAIN 187..277
FT /note="Ig-like 1"
FT DOMAIN 468..557
FT /note="Ig-like 2"
FT DOMAIN 2034..2137
FT /note="Ig-like 3"
FT DOMAIN 2244..2339
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 2344..2443
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 2445..2540
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 2544..2628
FT /note="Ig-like 4"
FT DOMAIN 2641..2735
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 2749..2845
FT /note="Ig-like 5"
FT REGION 82..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1350..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1827..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 347..380
FT /evidence="ECO:0000255"
FT COMPBIAS 666..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1654..1674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1956..1971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1989..2020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2021..2055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..2617
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035061"
FT VAR_SEQ 1..2204
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:20206623"
FT /id="VSP_035062"
FT VAR_SEQ 1..1048
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:20206623"
FT /id="VSP_039842"
FT VAR_SEQ 557..2051
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:20206623"
FT /id="VSP_039843"
FT VAR_SEQ 2205..2239
FT /note="WLCLPSVCRKDSGRYSVTLRSEGGCVQAEFTLQVI -> MGTRWWAATTRAS
FT NWLWQMATHGCASPACAGRTVA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:20206623"
FT /id="VSP_035065"
FT CONFLICT 2466
FT /note="P -> L (in Ref. 1; ACA28708)"
FT /evidence="ECO:0000305"
FT CONFLICT 2626
FT /note="E -> G (in Ref. 1; ACA28708)"
FT /evidence="ECO:0000305"
FT CONFLICT 2628
FT /note="T -> N (in Ref. 2; BAC29455)"
FT /evidence="ECO:0000305"
FT CONFLICT 2839
FT /note="T -> A (in Ref. 1; ACA28708)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2849 AA; 303658 MW; 70CB4356B4BE229C CRC64;
MNEMRTQVRI EFHALATQRK PSASPPTIEE DMGQGCTLEA LVIPSRRAEQ STQHPDSSFM
ATVRGAKSVV VSQWQLLQAG SAGSAARPDG SGSESLAASS SWKPRRRLEA GGPCRSWLVF
LVSREGWSDS NPGYRKQFIC RPQEIGFHSE EHREAGTMAA KPPKKSSIPG VSIRQLVDEI
PEGCSTPDFK QKPVTLALPE GKNAIFRAVV CGEPRPEVHW QSSKGDLSNS AKYQISSAPG
REEHVLQINK LTGEDSDLYR CTALNAYGEA TCSVRLTVIE VGFRKNRKRQ KEPQEDLRKE
LMDFRKMLKK RAPPPTPEKK MESEQVWQLL VTADRKDYEK ICMQYGIVDF RGMLRKLQEM
KKEQEDRMAQ YVSAIANLRH IKVTKEGVAT FDLELDLKNL ESKIYLYKDG EMIPYGVDNQ
TKHCLRRLGK RYHFQIQDLR PEDAGLYQVM VEDAVVFSTE LESRTIPPRV VVPLAETRCE
ERGDAVFECT LSNPCPSATW HFQHRPLRLS DKYEVFVSPD GLTHRLVVKG ASSSDMGLYS
LNTGLHASSA WLVVEGGKDK GPQTTDTDHR LQTPEALASE AEDAGGISIK GGQSRERGSL
KEISGAQLTA GPDRGAFGKH GYPLVVDEDI VNSTWGPGQD KKSFLEGGQL RVTLPGDSQS
QREGDCGRSL PRRSHLQGED TESDLGFLER GQQGPGRVDS ENGRWETAGG QSAGSSHPRD
RRLESRGEGQ EHSEGHGSEL DRYGQGQCHD PQLGAGAGQR VPWGSQFDAE GLQLKKEGTE
MWGDCLDVTE GRGNLRKERG TAAGSSNRAR LWEARGGSGA GSPCVPEFPR GGAHSSKAGM
GPECWPGGDA GHGEAGVYWG AGGYPGQTSE GNDTQKSSLS GDRKLLGCTS PEAKAEGSFQ
SADGHGIVGR VYKPGPEGPE DLRSQKSGLQ EIQGRNGQGS AGALGRTVEG SRSLQFPQSW
TVGQREAGKP GGAEYEDIGP QDDTWSNLRE MGGHCGSGVL ASGGREGSVG GSQVAALMMS
SQRVDARNHR LVTSPGLGVQ GSGRTLGHME GLRDPEAVGS EEEFWNGSGR SQGKGSRGGM
GLGGPEWAES RNEEGWENSE GMASRNGATC RDGSRMQEGT GSGPDIGCKA PCGAPAETES
GKWGTYSHDS GVPGGLWSGS KSQCSPAGKV SGREASLRNG SAGLHGMPSS EAQQRDVFQG
HGQTGHIGEH HCARGLGSSE TVGSVGGHGR KDSGTAGKVG EGYTEAEPGH SGGLSSWGHT
GDYEDFRVLG AFREGDFGNG TGVPLSMGPR SLERGDKEGD GERISFLGAR TSTVGTGNWD
KARHPGAPSP HEAGSEGHWA QVSGNALGCR DGSGIPEPWS AGDKTAYGEE SKGLGPERTG
PDGEVAFRGS SSSLRGMGPA SEASYKSGTW GPGAVGSGFK VDCRNDLGCS GSMGSESKAG
YKNKIESHGV RELGDLTGYK NDLGPSELIS SRNEARGLEH SGDILSWNKA GLRDGLGETG
RMESKNGVGY RGSSVGPGEM GSERKMHLAD GSGRLGGPGS LAAPKEHESV GLGSVYEGAA
EIGSKYNREK VRGMGFRDAT GPEVGSGVAG MLDITGGIAH GDSAMGTEKL GTPDRPYILS
GGQGTKNSLG GCVSLGIPDA LGAVGSVGKP GIREWKDDSG FQGSLRDRGT PSEEIRSVDQ
AGAIGTSRLL DSRGAVEDGS GSENDFDFNK SGLETTGRCR VADQQGVTPQ GCGGSLLNGR
RKGTSSGSLS GVGQEVDRSS TPGRETKVMS GPGSGRATSH TRAADWEDGV QCSFGASSSL
PDTDAIFRET HAGQGAFKGR GCETGQGAAG ECQGPRSLGS RGSEFVGGRA GFTGSSSVPG
RRDSTIYGDA VTSKPQEPQN ELYSPLGRRD FKSVSGGIQE PGFQRGTGQG EGKESFQESG
SWEAELDEVQ GSRASAKFEN QGGKDPGWSG QKPGPCGSRH QVQSGTEVGS AKRATPQGAG
GLEPWAGSED RGSLREPWSE DRRQGPHRHL GSRRDTQEGR SDVCGQAQDA TQSPRSRYQP
GTGRSSSEAR GSMDHFSQGL TDTEVQLGEA AIVSCTLASD LGPGTWFKDG VKLTAQDGVI
FEQDGLTHRL ILTHVEGTQA GKYTFVAGCQ HSEASLTVQD PPTIAPDVTE TLREPLVFKA
GKPVTVKIPF QSRLPVQAAW RKDGNEVVGG DHKGIQLALA DGYTWLCLPS VCRKDSGRYS
VTLRSEGGCV QAEFTLQVID KPQPPQGPLE VQDCHRAGVC LRWLPPRDNG GQVIQHYVVE
RRQAGRSTWL KVGEPPSDST SFTDTSVEQG KKYAFRVRAV TSVGAGDALE SEEVLVAPEA
LPGPPSAPAI LSASSQSITL TWGAPQGPGS NHILGYLIEK HKKGSNTWMA VNEQPVSERR
YTVVGLRQGC QYEFRVTAVT LSGPGDPGPP SDAVFARDPM RPPGPVRDLQ VTDTSNTSIT
VSWMVPDARD ADEAQGYIVE LCGSDSHQWS PCHVGTVPGT TFTAKGLRPQ EGYFVRVTAV
NDGGRSQATS LDTLVHAMPA TVCPRFLMDS GTKDTLMVRV GDSIRVPLSF EAAPMPEVTW
LKDGLPLPKR SVTTVKAGLT QLLIPAASLS DCGRYTVMLR NLQGKEATHS FFINVAACPQ
APGSIYLQEN VPGTVTVQWE PSPDEAQGIP LHYTVLMRSS SHRSWHEVAD HVRTNRFTLL
GVLPGHEYHF RVLAKNELGV SKPSDTSQPW CIPRQRDRFT VKSPTYQDPD LSQKPRFLVG
LRAHLLPQGC ECRMTCAVQG SPQPHVTWFK NDQSLDRNPA VYSTDLLGVC SLVIPSVSLK
DSGEYKAVAK NPLGQAVSTA TLIVTEYDS
