ID   IGFR1_BOVIN             Reviewed;         357 AA.
AC   A5PJC7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=IGF-like family receptor 1;
DE   AltName: Full=Transmembrane protein 149;
DE   Flags: Precursor;
GN   Name=IGFLR1; Synonyms=TMEM149;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable cell membrane receptor for the IGF-like family
CC       protein IGFL. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
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DR   EMBL; BC142051; AAI42052.1; -; mRNA.
DR   RefSeq; NP_001092637.1; NM_001099167.2.
DR   AlphaFoldDB; A5PJC7; -.
DR   SMR; A5PJC7; -.
DR   STRING; 9913.ENSBTAP00000003585; -.
DR   PaxDb; A5PJC7; -.
DR   PRIDE; A5PJC7; -.
DR   Ensembl; ENSBTAT00000003585; ENSBTAP00000003585; ENSBTAG00000002764.
DR   GeneID; 617594; -.
DR   KEGG; bta:617594; -.
DR   CTD; 79713; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002764; -.
DR   VGNC; VGNC:30091; IGFLR1.
DR   eggNOG; ENOG502RZ9Q; Eukaryota.
DR   GeneTree; ENSGT00390000005702; -.
DR   HOGENOM; CLU_877045_0_0_1; -.
DR   InParanoid; A5PJC7; -.
DR   OrthoDB; 1035824at2759; -.
DR   TreeFam; TF338761; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000002764; Expressed in mesenteric lymph node and 105 other tissues.
DR   ExpressionAtlas; A5PJC7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   Gene3D; 1.10.533.10; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR042355; IGFLR1.
DR   PANTHER; PTHR14657; PTHR14657; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Receptor; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..357
FT                   /note="IGF-like family receptor 1"
FT                   /id="PRO_0000409154"
FT   TOPO_DOM        23..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..357
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          100..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  38288 MW;  0F5D34FCE42D0992 CRC64;
     MGPLRLLPTA VLLLAQAAPW EASQHCGRLE YWNPDNRCCG SCLQRFGPPP CADLEFSENC
     GLDDAGNHVM HPFQECPPGQ CNRNSAELCS LCGGGATAPI PSGSRGGTGR PCREPVPNKE
     PCPLTPGKSS ILSSQEPSSP GIPSVSWTSE HKAPQQAWPS LSFALFLVLV LLVTSAIILL
     ALQRHHRRLD QGKAVQHPYP SLVCSDLDTH TRFLHLSSPA SLETSEARDS WKEVSLSPLL
     GREMPSLESQ PLSRLLDELE VLEELILLLD PEPGPGGRMA CGTTRHLAAR YGLPAAWSTF
     AYSLRPSRSP LRALIEMVVA REPSASLGQL GTHLAQIGRA DALQVLSKLG SSGACLA