IGFR1_MOUSE
ID IGFR1_MOUSE Reviewed; 345 AA.
AC Q3U4N7; Q8VE58;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=IGF-like family receptor 1;
DE AltName: Full=Transmembrane protein 149;
DE Flags: Precursor;
GN Name=Igflr1; Synonyms=Tmem149;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=NOD; TISSUE=Dendritic cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21454693; DOI=10.1074/jbc.m111.224626;
RA Lobito A.A., Ramani S.R., Tom I., Bazan J.F., Luis E., Fairbrother W.J.,
RA Ouyang W., Gonzalez L.C.;
RT "Murine IGFL and human IGFL1 are induced in inflammatory skin conditions
RT and bind to a novel TNF receptor family member, IGFLR1.";
RL J. Biol. Chem. 286:18969-18981(2011).
CC -!- FUNCTION: Probable cell membrane receptor for the IGF-like family
CC protein IGFL. {ECO:0000269|PubMed:21454693}.
CC -!- INTERACTION:
CC Q3U4N7; Q6B9Z0: Igfl; NbExp=3; IntAct=EBI-3870498, EBI-3870418;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21454693};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:21454693}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3U4N7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U4N7-2; Sequence=VSP_026146;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in
CC lymph node. Highly expressed in T-cells and monocytes.
CC {ECO:0000269|PubMed:21454693}.
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DR EMBL; AK154129; BAE32394.1; -; mRNA.
DR EMBL; BC019733; AAH19733.1; -; mRNA.
DR CCDS; CCDS39886.1; -. [Q3U4N7-1]
DR RefSeq; NP_663555.2; NM_145580.2. [Q3U4N7-1]
DR AlphaFoldDB; Q3U4N7; -.
DR SMR; Q3U4N7; -.
DR IntAct; Q3U4N7; 1.
DR STRING; 10090.ENSMUSP00000042312; -.
DR GlyGen; Q3U4N7; 1 site.
DR PhosphoSitePlus; Q3U4N7; -.
DR PaxDb; Q3U4N7; -.
DR PRIDE; Q3U4N7; -.
DR ProteomicsDB; 269535; -. [Q3U4N7-1]
DR ProteomicsDB; 269536; -. [Q3U4N7-2]
DR Antibodypedia; 2411; 82 antibodies from 17 providers.
DR DNASU; 101883; -.
DR Ensembl; ENSMUST00000043850; ENSMUSP00000042312; ENSMUSG00000036826. [Q3U4N7-1]
DR GeneID; 101883; -.
DR KEGG; mmu:101883; -.
DR UCSC; uc009gfb.1; mouse. [Q3U4N7-1]
DR CTD; 79713; -.
DR MGI; MGI:3655979; Igflr1.
DR VEuPathDB; HostDB:ENSMUSG00000036826; -.
DR eggNOG; ENOG502RZ9Q; Eukaryota.
DR GeneTree; ENSGT00390000005702; -.
DR InParanoid; Q3U4N7; -.
DR OMA; TLPFREC; -.
DR OrthoDB; 1035824at2759; -.
DR PhylomeDB; Q3U4N7; -.
DR TreeFam; TF338761; -.
DR BioGRID-ORCS; 101883; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Igflr1; mouse.
DR PRO; PR:Q3U4N7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3U4N7; protein.
DR Bgee; ENSMUSG00000036826; Expressed in bone marrow and 51 other tissues.
DR ExpressionAtlas; Q3U4N7; baseline.
DR Genevisible; Q3U4N7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR042355; IGFLR1.
DR PANTHER; PTHR14657; PTHR14657; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..345
FT /note="IGF-like family receptor 1"
FT /id="PRO_0000290358"
FT TOPO_DOM 21..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 106..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026146"
FT CONFLICT 156
FT /note="R -> Q (in Ref. 2; AAH19733)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="G -> S (in Ref. 2; AAH19733)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 37172 MW; B66AF0D33849BE9A CRC64;
MGPSWLLWTV AVAVLLLTRA ASMEASSFCG HLEYWNSDKR CCSRCLQRFG PPACPDHEFT
ENCGLNDFGD TVAHPFKKCS PGYCNPNGTE LCSQCSSGAA AAPAHVESPG RTHKQCRKKP
VPPKDVCPLK PEDAGASSSP GRWSLGQTTK NEVSSRPGFV SASVLPLAVL PLLLVLLLIL
AVVLLSLFKR KVRSRPGSSS AFGDPSTSLH YWPCPGTLEV LESRNRGKAN LLQLSSWELQ
GLASQPLSLL LDELEVLEEL IMLLDPEPGP SGSTAYGTTR HLAARYGLPA TWSTFAYSLR
PSRSPLRALI EMVVAREPSA TLGQFGTYLA QLGRTDALQV LSKLG
