ID   IGF_MYXGL               Reviewed;         139 AA.
AC   P22618;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Insulin-like growth factor;
DE            Short=IGF;
DE   Flags: Precursor; Fragment;
OS   Myxine glutinosa (Atlantic hagfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Myxininae; Myxine.
OX   NCBI_TaxID=7769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1989990; DOI=10.1016/s0021-9258(18)52257-2;
RA   Nagamatsu S., Chan S.J., Falkmer S., Steiner D.F.;
RT   "Evolution of the insulin gene superfamily. Sequence of a preproinsulin-
RT   like growth factor cDNA from the Atlantic hagfish.";
RL   J. Biol. Chem. 266:2397-2402(1991).
CC   -!- FUNCTION: The insulin-like growth factors, isolated from plasma, are
CC       structurally and functionally related to insulin but have a much higher
CC       growth-promoting activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; M57735; AAA49265.1; -; mRNA.
DR   PIR; A38612; A38612.
DR   AlphaFoldDB; P22618; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR022350; Insulin-like_growth_factor.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02002; INSLNLIKEGF.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Growth factor; Mitogen; Secreted; Signal.
FT   SIGNAL          <1..38
FT   CHAIN           39..139
FT                   /note="Insulin-like growth factor"
FT                   /id="PRO_0000015733"
FT   REGION          39..67
FT                   /note="B"
FT   REGION          68..82
FT                   /note="C"
FT   REGION          83..103
FT                   /note="A"
FT   REGION          104..113
FT                   /note="D"
FT   REGION          108..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..139
FT                   /note="E"
FT   COMPBIAS        119..139
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   139 AA;  16087 MW;  2FC888C8D074FAC1 CRC64;
     YIRRVRQGSI YSLLVESQQW CKLTLTLLLL LALLTRCTLS ETLCGSELVD TLQFVCDDRG
     FFFVPQHVPP RRGAHRRSRA RKGIVEECCF KGCSLRLLEM YCARPSKAER DVARPRQRPH
     RASQHSRRGS QSRGRGRSR