IGG2A_RAT
ID IGG2A_RAT Reviewed; 322 AA.
AC P20760;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Ig gamma-2A chain C region;
GN Name=Igg-2a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3149946; DOI=10.1016/0378-1119(88)90180-1;
RA Brueggemann M.;
RT "Evolution of the rat immunoglobulin gamma heavy-chain gene family.";
RL Gene 74:473-482(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-322.
RX PubMed=3016742; DOI=10.1073/pnas.83.16.6075;
RA Bruggemann M., Free J., Diamond A., Howard J., Cobbold S., Waldmann H.;
RT "Immunoglobulin heavy chain locus of the rat: striking homology to mouse
RT antibody genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:6075-6079(1986).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA41376.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M13804; AAA41376.1; ALT_INIT; Genomic_DNA.
DR PIR; PS0019; PS0019.
DR PDB; 1FN4; X-ray; 2.80 A; B/D=4-102.
DR PDB; 1I1A; X-ray; 2.80 A; C/D=98-322.
DR PDB; 1I1C; X-ray; 2.70 A; A/B=98-322.
DR PDB; 4UAO; X-ray; 3.10 A; C=1-102.
DR PDBsum; 1FN4; -.
DR PDBsum; 1I1A; -.
DR PDBsum; 1I1C; -.
DR PDBsum; 4UAO; -.
DR AlphaFoldDB; P20760; -.
DR SMR; P20760; -.
DR IntAct; P20760; 2.
DR STRING; 10116.ENSRNOP00000062949; -.
DR CarbonylDB; P20760; -.
DR GlyGen; P20760; 1 site.
DR PaxDb; P20760; -.
DR PRIDE; P20760; -.
DR RGD; 1359626; Igg-2a.
DR eggNOG; ENOG502R54U; Eukaryota.
DR InParanoid; P20760; -.
DR PhylomeDB; P20760; -.
DR EvolutionaryTrace; P20760; -.
DR PRO; PR:P20760; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 3.
DR SMART; SM00407; IGc1; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat.
FT CHAIN <1..322
FT /note="Ig gamma-2A chain C region"
FT /id="PRO_0000153592"
FT DOMAIN 6..98
FT /note="Ig-like 1"
FT DOMAIN 115..212
FT /note="Ig-like 2"
FT DOMAIN 221..317
FT /note="Ig-like 3"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..82
FT DISULFID 102
FT /note="Interchain (with a heavy chain)"
FT DISULFID 105
FT /note="Interchain (with a heavy chain)"
FT DISULFID 107
FT /note="Interchain (with a heavy chain)"
FT DISULFID 136..196
FT DISULFID 242..300
FT NON_TER 1
FT STRAND 7..11
FT /evidence="ECO:0007829|PDB:1FN4"
FT STRAND 19..22
FT /evidence="ECO:0007829|PDB:1FN4"
FT STRAND 25..32
FT /evidence="ECO:0007829|PDB:1FN4"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:4UAO"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:1FN4"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:4UAO"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:4UAO"
FT STRAND 66..68
FT /evidence="ECO:0007829|PDB:1FN4"
FT HELIX 72..77
FT /evidence="ECO:0007829|PDB:4UAO"
FT STRAND 81..85
FT /evidence="ECO:0007829|PDB:4UAO"
FT TURN 87..90
FT /evidence="ECO:0007829|PDB:1FN4"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:4UAO"
FT STRAND 115..118
FT /evidence="ECO:0007829|PDB:1I1C"
FT HELIX 122..125
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 128..130
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 133..141
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 142..144
FT /evidence="ECO:0007829|PDB:1I1A"
FT STRAND 149..156
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 163..169
FT /evidence="ECO:0007829|PDB:1I1A"
FT TURN 171..173
FT /evidence="ECO:0007829|PDB:1I1A"
FT STRAND 175..182
FT /evidence="ECO:0007829|PDB:1I1C"
FT HELIX 185..189
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 194..199
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 201..205
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 207..211
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 222..226
FT /evidence="ECO:0007829|PDB:1I1C"
FT HELIX 230..234
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 235..250
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 253..258
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 264..268
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 279..288
FT /evidence="ECO:0007829|PDB:1I1C"
FT HELIX 289..293
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 298..303
FT /evidence="ECO:0007829|PDB:1I1C"
FT HELIX 308..310
FT /evidence="ECO:0007829|PDB:1I1C"
FT STRAND 311..316
FT /evidence="ECO:0007829|PDB:1I1C"
SQ SEQUENCE 322 AA; 35186 MW; E8EA136A9DE01EDB CRC64;
AETTAPSVYP LAPGTALKSN SMVTLGCLVK GYFPEPVTVT WNSGALSSGV HTFPAVLQSG
LYTLTSSVTV PSSTWSSQAV TCNVAHPASS TKVDKKIVPR ECNPCGCTGS EVSSVFIFPP
KTKDVLTITL TPKVTCVVVD ISQNDPEVRF SWFIDDVEVH TAQTHAPEKQ SNSTLRSVSE
LPIVHRDWLN GKTFKCKVNS GAFPAPIEKS ISKPEGTPRG PQVYTMAPPK EEMTQSQVSI
TCMVKGFYPP DIYTEWKMNG QPQENYKNTP PTMDTDGSYF LYSKLNVKKE TWQQGNTFTC
SVLHEGLHNH HTEKSLSHSP GK
