IGG2B_RAT
ID IGG2B_RAT Reviewed; 333 AA.
AC P20761;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ig gamma-2B chain C region;
DE AltName: Full=Immunoglobulin heavy chain 1a;
GN Name=Igh-1a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3149946; DOI=10.1016/0378-1119(88)90180-1;
RA Brueggemann M.;
RT "Evolution of the rat immunoglobulin gamma heavy-chain gene family.";
RL Gene 74:473-482(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 227-333.
RX PubMed=3016742; DOI=10.1073/pnas.83.16.6075;
RA Bruggemann M., Free J., Diamond A., Howard J., Cobbold S., Waldmann H.;
RT "Immunoglobulin heavy chain locus of the rat: striking homology to mouse
RT antibody genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:6075-6079(1986).
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DR PIR; PS0018; PS0018.
DR PDB; 1BFO; X-ray; 2.60 A; B/D/F/H=1-95.
DR PDB; 1C5D; X-ray; 2.40 A; B/H=1-98.
DR PDB; 2ARJ; X-ray; 2.88 A; B/H=1-98.
DR PDB; 3B9K; X-ray; 2.70 A; D/H=1-96.
DR PDBsum; 1BFO; -.
DR PDBsum; 1C5D; -.
DR PDBsum; 2ARJ; -.
DR PDBsum; 3B9K; -.
DR AlphaFoldDB; P20761; -.
DR SMR; P20761; -.
DR IntAct; P20761; 2.
DR MINT; P20761; -.
DR STRING; 10116.ENSRNOP00000044037; -.
DR jPOST; P20761; -.
DR PaxDb; P20761; -.
DR PRIDE; P20761; -.
DR RGD; 1305720; Igh-1a.
DR eggNOG; ENOG502R54U; Eukaryota.
DR HOGENOM; CLU_030625_0_2_1; -.
DR InParanoid; P20761; -.
DR OMA; CIVIHEA; -.
DR EvolutionaryTrace; P20761; -.
DR PRO; PR:P20761; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000048402; Expressed in spleen and 17 other tissues.
DR Genevisible; P20761; RN.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 3.
DR SMART; SM00407; IGc1; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Immunoglobulin domain; Reference proteome;
KW Repeat.
FT CHAIN <1..333
FT /note="Ig gamma-2B chain C region"
FT /id="PRO_0000153593"
FT DOMAIN 6..96
FT /note="Ig-like 1"
FT DOMAIN 124..223
FT /note="Ig-like 2"
FT DOMAIN 232..328
FT /note="Ig-like 3"
FT DISULFID 15
FT /note="Interchain (with a light chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 27..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 106
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 109
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 112
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 115
FT /note="Interchain (with a heavy chain)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 147..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 253..311
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 1
FT STRAND 8..11
FT /evidence="ECO:0007829|PDB:1C5D"
FT STRAND 21..35
FT /evidence="ECO:0007829|PDB:1C5D"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:1C5D"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:1C5D"
FT STRAND 48..52
FT /evidence="ECO:0007829|PDB:1BFO"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:1C5D"
FT STRAND 61..72
FT /evidence="ECO:0007829|PDB:1C5D"
FT TURN 73..75
FT /evidence="ECO:0007829|PDB:1C5D"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:1C5D"
FT HELIX 85..87
FT /evidence="ECO:0007829|PDB:1C5D"
FT STRAND 89..94
FT /evidence="ECO:0007829|PDB:1C5D"
SQ SEQUENCE 333 AA; 36497 MW; 55F8B64D48D460A6 CRC64;
AQTTAPSVYP LAPGCGDTTS STVTLGCLVK GYFPEPVTVT WNSGALSSDV HTFPAVLQSG
LYTLTSSVTS STWPSQTVTC NVAHPASSTK VDKKVERRNG GIGHKCPTCP TCHKCPVPEL
LGGPSVFIFP PKPKDILLIS QNAKVTCVVV DVSEEEPDVQ FSWFVNNVEV HTAQTQPREE
QYNSTFRVVS ALPIQHQDWM SGKEFKCKVN NKALPSPIEK TISKPKGLVR KPQVYVMGPP
TEQLTEQTVS LTCLTSGFLP NDIGVEWTSN GHIEKNYKNT EPVMDSDGSF FMYSKLNVER
SRWDSRAPFV CSVVHEGLHN HHVEKSISRP PGK
