ID   IGG2C_RAT               Reviewed;         329 AA.
AC   P20762;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Ig gamma-2C chain C region;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3127222; DOI=10.1002/eji.1830180222;
RA   Brueggemann M., Delmastro-Galfre P., Waldmann H., Calabi F.;
RT   "Sequence of a rat immunoglobulin gamma 2c heavy chain constant region
RT   cDNA: extensive homology to mouse gamma 3.";
RL   Eur. J. Immunol. 18:317-319(1988).
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DR   EMBL; X07189; CAA30169.1; -; mRNA.
DR   PIR; S00847; S00847.
DR   AlphaFoldDB; P20762; -.
DR   SMR; P20762; -.
DR   STRING; 10116.ENSRNOP00000060258; -.
DR   GlyGen; P20762; 1 site, 2 N-linked glycans (1 site).
DR   PaxDb; P20762; -.
DR   PRIDE; P20762; -.
DR   Ensembl; ENSRNOT00000111892; ENSRNOP00000078974; ENSRNOG00000065917.
DR   eggNOG; ENOG502R54U; Eukaryota.
DR   GeneTree; ENSGT00940000163307; -.
DR   PhylomeDB; P20762; -.
DR   TreeFam; TF334176; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 3.
DR   SMART; SM00407; IGc1; 3.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Reference proteome.
FT   CHAIN           <1..329
FT                   /note="Ig gamma-2C chain C region"
FT                   /id="PRO_0000153594"
FT   REGION          1..97
FT                   /note="CH1"
FT   REGION          98..113
FT                   /note="Hinge"
FT   REGION          114..222
FT                   /note="CH2"
FT   REGION          223..329
FT                   /note="CH3"
FT   DISULFID        15
FT                   /note="Interchain (with a light chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        27..82
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        111
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        113
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        143..203
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        249..307
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   329 AA;  36572 MW;  5FCD7B7933850773 CRC64;
     ARTTAPSVYP LVPGCSGTSG SLVTLGCLVK GYFPEPVTVK WNSGALSSGV HTFPAVLQSG
     LYTLSSSVTV PSSTWSSQTV TCSVAHPATK SNLIKRIEPR RPKPRPPTDI CSCDDNLGRP
     SVFIFPPKPK DILMITLTPK VTCVVVDVSE EEPDVQFSWF VDNVRVFTAQ TQPHEEQLNG
     TFRVVSTLHI QHQDWMSGKE FKCKVNNKDL PSPIEKTISK PRGKARTPQV YTIPPPREQM
     SKNKVSLTCM VTSFYPASIS VEWERNGELE QDYKNTLPVL DSDESYFLYS KLSVDTDSWM
     RGDIYTCSVV HEALHNHHTQ KNLSRSPGK