ID   IGHA_RABIT              Reviewed;         299 AA.
AC   P01879;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Ig alpha chain C region;
DE   Flags: Fragment;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6322114; DOI=10.1093/nar/12.3.1657;
RA   Knight K.L., Martens C.L., Stoklosa C.M., Schneiderman R.D.;
RT   "Genes encoding alpha-heavy chains of rabbit IgA: characterization of cDNA
RT   encoding IgA-g subclass alpha-chains.";
RL   Nucleic Acids Res. 12:1657-1670(1984).
CC   -!- FUNCTION: Ig alpha is the major immunoglobulin class in body
CC       secretions. It may serve both to defend against local infection and to
CC       prevent access of foreign antigens to the general immunologic system.
CC   -!- MISCELLANEOUS: This immunoglobulin belongs to the IgA-G subclass. It
CC       was isolated from a rabbit homozygous FOR A2, N80, DE12, 15, F71, G75
CC       heavy chain haplotype.
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DR   EMBL; X00353; CAA25100.1; -; mRNA.
DR   PIR; A02174; AHRB.
DR   AlphaFoldDB; P01879; -.
DR   SMR; P01879; -.
DR   PRIDE; P01879; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003599; Ig_sub.
DR   Pfam; PF07654; C1-set; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00407; IGc1; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00290; IG_MHC; 2.
PE   2: Evidence at transcript level;
KW   Immunoglobulin domain; Reference proteome; Repeat.
FT   CHAIN           <1..299
FT                   /note="Ig alpha chain C region"
FT                   /id="PRO_0000153569"
FT   DOMAIN          71..167
FT                   /note="Ig-like 1"
FT   DOMAIN          174..276
FT                   /note="Ig-like 2"
FT   NON_TER         1
SQ   SEQUENCE   299 AA;  32256 MW;  2512FE3F62E9A223 CRC64;
     QSGTSGPYTA CSELILPVTQ CLGQKSAACH VEYNSVINES LPVPFPDCCP ANSCCTCPSS
     SSRNLISGCQ PSLSLQRPDL GDLLLGRDAS LTCTLSGLKN PEDAVFTWEP TNGNEPVQQR
     AQRDLSGCYS VSSVLPSSAE TWKARTEFTC TVTHPEIDSG SLTATISRGV VTPPQVHLLP
     PPSEELALNE QVTLTCLVRG FSPKDVLVSW RHQGQEVPED SFLVWKSMPE SSQDKATYAI
     TSLLRVPAED WNQGDTYSCM VGHEGLAEHF TQKTIDRLAG KPTHVNVSVV VADVEAVCY