ID   IGHD_MOUSE              Reviewed;         257 AA.
AC   P01881;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=Ig delta chain C region secreted form;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-248 (TEPC 1017).
RX   PubMed=6968091; DOI=10.1126/science.6968091;
RA   Tucker P.W., Liu C.-P., Mushinski J.F., Blattner F.R.;
RT   "Mouse immunoglobulin D: messenger RNA and genomic DNA sequences.";
RL   Science 209:1353-1360(1980).
RN   [2]
RP   PROTEIN SEQUENCE OF 231-257 (B1-8.DELTA-1).
RX   PubMed=6895102; DOI=10.1038/292061a0;
RA   Dildrop R., Beyreuther K.;
RT   "C-terminal sequence of the secreted form of mouse IgD heavy chain.";
RL   Nature 292:61-63(1981).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-257.
RX   PubMed=6801528; DOI=10.1038/296410a0;
RA   Cheng H.-L., Blattner F.R., Fitzmaurice L., Mushinski J.F., Tucker P.W.;
RT   "Structure of genes for membrane and secreted murine IgD heavy chains.";
RL   Nature 296:410-415(1982).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Secreted;
CC         IsoId=P01881-1; Sequence=Displayed;
CC       Name=Membrane-bound;
CC         IsoId=P01882-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Cell lines producing IgD contain several mRNA
CC       species for Ig delta chains. In plasmacytomas, the secreted form is the
CC       major component, and the membrane-bound form is a minor component. In
CC       spleen, however, the membrane-bound form is the major component. These
CC       two forms differ in their C-terminal segments.
CC   -!- MISCELLANEOUS: This delta chain lacks the domain corresponding to the
CC       CH2 domain of human delta chain.
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DR   EMBL; J00447; AAB59652.1; -; Genomic_DNA.
DR   EMBL; J00448; AAB59652.1; JOINED; Genomic_DNA.
DR   EMBL; J00449; AAB59652.1; JOINED; Genomic_DNA.
DR   EMBL; J00450; AAB59652.1; JOINED; Genomic_DNA.
DR   PIR; A02176; DHMS.
DR   AlphaFoldDB; P01881; -.
DR   SMR; P01881; -.
DR   GlyGen; P01881; 5 sites.
DR   PRIDE; P01881; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P01881; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0050776; P:regulation of immune response; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Immunoglobulin domain; Reference proteome; Repeat; Secreted.
FT   CHAIN           <1..257
FT                   /note="Ig delta chain C region secreted form"
FT                   /id="PRO_0000153571"
FT   DOMAIN          5..105
FT                   /note="Ig-like 1"
FT   DOMAIN          133..233
FT                   /note="Ig-like 2"
FT   REGION          89..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        227
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        13
FT                   /note="Interchain (with light chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        26..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        155
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   257 AA;  28368 MW;  7277EED06840C44E CRC64;
     DKKEPDMFLL SECKAPEENE KINLGCLVIG SQPLKISWEP KKSSIVEHVF PSEMRNGNYT
     MVLQVTVLAS ELNLNHTCTI NKPKRKEKPF KFPESWDSQS SKRVTPTLQA KNHSTEATKA
     ITTKKDIEGA MAPSNLTVNI LTTSTHPEMS SWLLCEVSGF FPENIHLMWL GVHSKMKSTN
     FVTANPTAQP GGTFQTWSVL RLPVALSSSL DTYTCVVEHE ASKTKLNASK SLAISGCYHL
     LPESDGPSRR PDGPALA