ID   IGHG2_CAVPO             Reviewed;         329 AA.
AC   P01862;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   17-JUN-2020, entry version 73.
DE   RecName: Full=Ig gamma-2 chain C region;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-3.
RA   Trischmann T.M.;
RL   Submitted (APR-1975) to the PIR data bank.
RN   [2]
RP   PROTEIN SEQUENCE OF 4-68.
RX   PubMed=5538606; DOI=10.1021/bi00777a003;
RA   Birshtein B.K., Hussain Q.Z., Cebra J.J.;
RT   "Structure of heavy chain from strain 13 guinea pig immunoglobulin-G(2). 3.
RT   Amino acid sequence of the region around the half-cystine joining heavy and
RT   light chains.";
RL   Biochemistry 10:18-25(1971).
RN   [3]
RP   PROTEIN SEQUENCE OF 69-133 AND 312-329.
RX   PubMed=5538616; DOI=10.1021/bi00777a002;
RA   Turner K.J., Cebra J.J.;
RT   "Structure of heavy chain from strain 13 guinea pig immunoglobulin-G(2).
RT   II. Amino acid sequence of the carboxyl-terminal and hinge region cyanogen
RT   bromide fragments.";
RL   Biochemistry 10:9-17(1971).
RN   [4]
RP   PROTEIN SEQUENCE OF 134-226.
RX   PubMed=4429665; DOI=10.1021/bi00720a018;
RA   Tracey D.E., Cebra J.J.;
RT   "Primary structure of the CH2 homology region from guinea pig IgG2
RT   antibodies.";
RL   Biochemistry 13:4796-4803(1974).
RN   [5]
RP   PROTEIN SEQUENCE OF 227-311.
RX   PubMed=4609467; DOI=10.1021/bi00720a019;
RA   Trischmann T.M., Cebra J.J.;
RT   "Primary structure of the CH3 homology region from guinea pig IgG2
RT   antibodies.";
RL   Biochemistry 13:4804-4811(1974).
RN   [6]
RP   DISULFIDE BONDS.
RX   PubMed=4922544; DOI=10.1021/bi00777a004;
RA   Oliveira B., Lamm M.E.;
RT   "Interchain disulfide bridges of guinea pig gamma-2-immunoglobulin.";
RL   Biochemistry 10:26-31(1971).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: This chain was isolated from pooled serum of strain 13
CC       inbred guinea pigs.
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DR   PIR; A94553; G2GP.
DR   iPTMnet; P01862; -.
DR   PRIDE; P01862; -.
DR   ABCD; P01862; 3 sequenced antibodies.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 3.
DR   SMART; SM00407; IGc1; 3.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Reference proteome; Secreted.
FT   CHAIN           <1..329
FT                   /note="Ig gamma-2 chain C region"
FT                   /id="PRO_0000153577"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:4429665"
FT   DISULFID        16
FT                   /note="Interchain (with a light chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   DISULFID        28..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   DISULFID        105
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   DISULFID        107
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   DISULFID        110
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   DISULFID        142..202
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   DISULFID        248..308
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT                   ECO:0000269|PubMed:4922544"
FT   NON_TER         1
SQ   SEQUENCE   329 AA;  36074 MW;  5D231B7164D1FBA9 CRC64;
     SARTTAPSVF PLAASCVDTS GSMMTLGCLV KGYFPEPVTV KWNSGALTSG VHTFPAVLQS
     GLYSLTSMVT VPSSQKATCN VAHPASSTKV DKTVEPIRTP ZPBPCTCPKC PPPENLGGPS
     VFIFPPKPKD TLMISLTPRV TCVVVDVSQD EPEVQFTWFV DNKPVGNAET KPRVEQYNTT
     FRVESVLPIQ HQDWLRGKEF KCKVYNKALP APIEKTISKT KGAPRMPDVY TLPPSRDELS
     KSKVSVTCLI INFFPADIHV EWASNRVPVS EKEYKNTPPI EDADGSYFLY SKLTVDKSAW
     DQGTVYTCSV MHEALHNHVT QKAISRSPG