IGHG3_MOUSE
ID IGHG3_MOUSE Reviewed; 398 AA.
AC P03987; P22436;
DT 23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Ig gamma-3 chain C region;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=6092053; DOI=10.1002/j.1460-2075.1984.tb02089.x;
RA Wels J.A., Word C.J., Rimm D., Der-Balan G.P., Martinez H.M., Tucker P.W.,
RA Blattner F.R.;
RT "Structural analysis of the murine IgG3 constant region gene.";
RL EMBO J. 3:2041-2046(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 329-398.
RX PubMed=6314258; DOI=10.1093/nar/11.19.6775;
RA Komaromy M., Clayton L., Rogers J., Robertson S., Kettman J., Wall R.;
RT "The structure of the mouse immunoglobulin in gamma 3 membrane gene
RT segment.";
RL Nucleic Acids Res. 11:6775-6785(1983).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179.
RC STRAIN=C57BL/6J; TISSUE=Plasma;
RX PubMed=17330941; DOI=10.1021/pr0604559;
RA Bernhard O.K., Kapp E.A., Simpson R.J.;
RT "Enhanced analysis of the mouse plasma proteome using cysteine-containing
RT tryptic glycopeptides.";
RL J. Proteome Res. 6:987-995(2007).
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Membrane bound;
CC IsoId=P03987-1; Sequence=Displayed;
CC Name=2; Synonyms=Secreted;
CC IsoId=P03987-2; Sequence=VSP_034613;
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DR EMBL; J00451; AAB59655.1; -; Genomic_DNA.
DR EMBL; V01526; CAA24767.1; ALT_SEQ; Genomic_DNA.
DR PIR; A02156; G3MSM.
DR PIR; B02156; G3MSC.
DR PDB; 1CLZ; X-ray; 2.80 A; H=1-99.
DR PDB; 2VQ1; X-ray; 2.50 A; B/F=1-99.
DR PDBsum; 1CLZ; -.
DR PDBsum; 2VQ1; -.
DR AlphaFoldDB; P03987; -.
DR SMR; P03987; -.
DR MINT; P03987; -.
DR GlyGen; P03987; 3 sites.
DR iPTMnet; P03987; -.
DR PhosphoSitePlus; P03987; -.
DR CPTAC; non-CPTAC-3918; -.
DR MaxQB; P03987; -.
DR PeptideAtlas; P03987; -.
DR PRIDE; P03987; -.
DR ABCD; P03987; 2 sequenced antibodies.
DR UCSC; uc007pgp.1; mouse. [P03987-1]
DR EvolutionaryTrace; P03987; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P03987; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IPI:AgBase.
DR GO; GO:0050776; P:regulation of immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 3.
DR SMART; SM00407; IGc1; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell membrane; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Secreted;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1..398
FT /note="Ig gamma-3 chain C region"
FT /id="PRO_0000153590"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..97
FT /note="CH1"
FT REGION 98..113
FT /note="Hinge"
FT REGION 114..223
FT /note="CH2"
FT REGION 224..327
FT /note="CH3"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17330941"
FT CARBOHYD 322
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 328..398
FT /note="ELELNETCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSV
FT VQVKQTAIPDYRNMIGQGA -> GK (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034613"
FT CONFLICT 329
FT /note="L -> M (in Ref. 2; CAA24767)"
FT /evidence="ECO:0000305"
FT CONFLICT 333
FT /note="E -> G (in Ref. 2; CAA24767)"
FT /evidence="ECO:0000305"
FT NON_TER 1
FT STRAND 6..10
FT /evidence="ECO:0007829|PDB:1CLZ"
FT STRAND 20..34
FT /evidence="ECO:0007829|PDB:1CLZ"
FT STRAND 37..40
FT /evidence="ECO:0007829|PDB:1CLZ"
FT TURN 41..44
FT /evidence="ECO:0007829|PDB:1CLZ"
FT STRAND 49..51
FT /evidence="ECO:0007829|PDB:1CLZ"
FT STRAND 61..70
FT /evidence="ECO:0007829|PDB:1CLZ"
FT TURN 71..76
FT /evidence="ECO:0007829|PDB:1CLZ"
FT STRAND 79..85
FT /evidence="ECO:0007829|PDB:1CLZ"
FT HELIX 86..88
FT /evidence="ECO:0007829|PDB:1CLZ"
FT STRAND 90..96
FT /evidence="ECO:0007829|PDB:1CLZ"
SQ SEQUENCE 398 AA; 43929 MW; CF7F264B50A41B95 CRC64;
TTTAPSVYPL VPGCSDTSGS SVTLGCLVKG YFPEPVTVKW NYGALSSGVR TVSSVLQSGF
YSLSSLVTVP SSTWPSQTVI CNVAHPASKT ELIKRIEPRI PKPSTPPGSS CPPGNILGGP
SVFIFPPKPK DALMISLTPK VTCVVVDVSE DDPDVHVSWF VDNKEVHTAW TQPREAQYNS
TFRVVSALPI QHQDWMRGKE FKCKVNNKAL PAPIERTISK PKGRAQTPQV YTIPPPREQM
SKKKVSLTCL VTNFFSEAIS VEWERNGELE QDYKNTPPIL DSDGTYFLYS KLTVDTDSWL
QGEIFTCSVV HEALHNHHTQ KNLSRSPELE LNETCAEAQD GELDGLWTTI TIFISLFLLS
VCYSASVTLF KVKWIFSSVV QVKQTAIPDY RNMIGQGA
